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Rupert Beale

@bealelab

Group Leader, Cell Biology of Infection Lab @thecrick; Nephrologist @Royal Free Hospital. Own views etc.

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19.10.2023
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Latest posts by Rupert Beale @bealelab

Itโ€™s outstanding.

16.02.2026 22:06 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Am at the Old Vic. Lady behind me is recounting how she went to the opening night of Arcadia with Isaiah Berlin. Who apparently remarked โ€œoh itโ€™s just too clever clever cleverโ€.

16.02.2026 20:44 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 0

Good thread. The bill is really, really bad.

02.02.2026 11:20 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Fresh from organising #ksautophagy25 with Christie and Leon Iโ€™m now off to #ksautophagy26 - doesnโ€™t seem that long ago! Hopefully people will be interested to hear about viruses and CASM.

02.02.2026 09:24 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
quotes from the linked websites: 
" We recognize that much of the American public lost trust in the NIAID, the National Institutes of Health (NIH; of which the NIAID is a part), and in the greater scientific community.
Taubenberger, Powers & Bhattacharya, Nature Medicine
https://www.nature.com/articles/s41591-025-04160-1

Reference 4: Public confidence in U.S. health agencies slides, fueled by declines among Democrats. ASAPH/Annenberg Science Knowledge surveys (Annenberg Public Policy
Center, 2025).
https://www.annenbergpublicpolicycenter.org/public-confidence-in-u-s-health-agencies-slides-fueled-by-declines-among-democrats/
"The decline in confidence among Democrats comes amid
persistent attacks by leaders in the Republican administration about the competence and integrity of the health agencies.
" Confidence in Fauci, who stepped down from his NIAID post at the end of 2022, is statistically unchanged since
October

quotes from the linked websites: " We recognize that much of the American public lost trust in the NIAID, the National Institutes of Health (NIH; of which the NIAID is a part), and in the greater scientific community. Taubenberger, Powers & Bhattacharya, Nature Medicine https://www.nature.com/articles/s41591-025-04160-1 Reference 4: Public confidence in U.S. health agencies slides, fueled by declines among Democrats. ASAPH/Annenberg Science Knowledge surveys (Annenberg Public Policy Center, 2025). https://www.annenbergpublicpolicycenter.org/public-confidence-in-u-s-health-agencies-slides-fueled-by-declines-among-democrats/ "The decline in confidence among Democrats comes amid persistent attacks by leaders in the Republican administration about the competence and integrity of the health agencies. " Confidence in Fauci, who stepped down from his NIAID post at the end of 2022, is statistically unchanged since October

Did they read what they cite?

In @natmed.nature.com, NIH& NIAID leaders complain about a decrease in public trust, and cite a survey pointing to the Republicain administration as responsible for the recent decrease!

www.nature.com/articles/s41...
www.annenbergpublicpolicycenter.org/public-confi...

16.01.2026 16:38 ๐Ÿ‘ 33 ๐Ÿ” 7 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
The new vision from the National Institute of Allergy and Infectious Diseases (NIAID) - Nature Medicine Preparing for tomorrowโ€™s threats by enhancing our ability to help patients today.

Joรฃo Monteiro and the editorial board of @naturemedicine.bsky.social should be ashamed of themselves for publishing this trash. www.nature.com/articles/s41...

16.01.2026 14:23 ๐Ÿ‘ 62 ๐Ÿ” 16 ๐Ÿ’ฌ 9 ๐Ÿ“Œ 2

Congrats Jon!

02.01.2026 20:51 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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My main PhD paper is finally out! ๐ŸŽ‰

After ~5 years, itโ€™s published today in ๐˜•๐˜ข๐˜ต๐˜ถ๐˜ณ๐˜ฆ ๐˜๐˜ฎ๐˜ฎ๐˜ถ๐˜ฏ๐˜ฐ๐˜ญ๐˜ฐ๐˜จ๐˜บ.
@natimmunol.nature.com

It all started with an unexpected observation ๐Ÿ”:
๐Ÿ‘‰ Mice lacking the dendritic cell receptor DNGR-1 developed tumours earlier โฉ and more frequently ๐Ÿ“ˆ than wild-type mice.

1/11 ๐Ÿงต

02.01.2026 16:57 ๐Ÿ‘ 41 ๐Ÿ” 16 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 3

Congrats AJ too!

02.01.2026 20:50 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Preview
The vault associates with membranes in situ The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...

Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??

#CellBiology #WTFology

www.biorxiv.org/content/10.6...

16.12.2025 06:35 ๐Ÿ‘ 170 ๐Ÿ” 60 ๐Ÿ’ฌ 6 ๐Ÿ“Œ 5
St Lucy with her eyes on a plate, Muppet stylee

St Lucy with her eyes on a plate, Muppet stylee

Oh! And happy St Lucyโ€™s Day, one and all, may your eyes be healthy and free of infection

13.12.2025 15:39 ๐Ÿ‘ 61 ๐Ÿ” 2 ๐Ÿ’ฌ 11 ๐Ÿ“Œ 0

It was a good one. The stupidly expensive pasta (just expensive at half price) helped.

13.12.2025 19:39 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Iโ€™m quaffing some (Sainsburyโ€™s) Sicilian red and Iโ€™m not sure Iโ€™ve had a better Italian meal outside of Italy.

13.12.2025 19:23 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Missed this for a while! Tonight was a treat though, @flossieteacake.bsky.social found some half price fancy nduja tortelloni. We had them with an aubergine and tomato sauce to start, then had pork chop with pancetta, leek and kale; spinach with chilli and lemon, sautรฉ potatoes with rosemary.

13.12.2025 19:22 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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13.12.2025 19:19 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Lamb Koftas (before and after).

25.11.2025 22:16 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

@louiseoni.bsky.social :-)

11.11.2025 10:09 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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From the Rare Kidney Disease Centre

11.11.2025 09:30 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
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In London for the @lifearc.bsky.social annual meeting

11.11.2025 09:11 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Doctoral clinical fellows The Crick's clinical PhD programme.

Just a few weeks left to apply for our clinical PhD programme.

We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.

Learn more and see what positions are available โฌ‡๏ธ

www.crick.ac.uk/careers-and-...

30.10.2025 09:41 ๐Ÿ‘ 4 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Are you a clinician who wants to do a PhD? Come to @crick.ac.uk (you can even come to my lab).

30.10.2025 11:51 ๐Ÿ‘ 2 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I donโ€™t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americansโ€™ health data is no longer secure. Say goodbye to federal public health in any capacity. Itโ€™s a disaster. We wonโ€™t recover.

11.10.2025 03:05 ๐Ÿ‘ 13849 ๐Ÿ” 6130 ๐Ÿ’ฌ 507 ๐Ÿ“Œ 393
Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses

Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...

10.10.2025 13:08 ๐Ÿ‘ 5 ๐Ÿ” 6 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Carbonara.

14.09.2025 20:05 ๐Ÿ‘ 7 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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@southlondongirl.bsky.social right so I donโ€™t recommend swimming with your iPhone in your pocket. Long story, also boring. But Sicily, excellent, @flossieteacake.bsky.social said I should share this pasta alla Norma with you. Itโ€™s got Ricotta Salata and everything. Aces. Shall we do dinner sometime?

13.09.2025 00:59 ๐Ÿ‘ 5 ๐Ÿ” 0 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

No it's normal.

13.09.2025 00:51 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Congrats, very interesting work!

11.09.2025 12:56 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

The main thing - is it not already clear - RFKr Jr is uniquely unqualified to lead the HHS.

All main agencies under his watch - NIH, FDA, CMS - are also headed by incompetent contrarian peddlers of disinformation, conspiracy theories, and pseudoscience.

This will, and already does, cost lives.

15.08.2025 04:07 ๐Ÿ‘ 127 ๐Ÿ” 52 ๐Ÿ’ฌ 8 ๐Ÿ“Œ 0
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Notes from Beethovenโ€™s genome Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven with population-based datasets used to quantify musical achievement.

If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. ๐Ÿงช๐Ÿ‘‡

07.08.2025 11:09 ๐Ÿ‘ 201 ๐Ÿ” 95 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 11

I know we're supposed to reflexively dismiss the loss of any niche subject in the humanities, but this is a big part of why the university exists: so a student who wants to learn Basque can learn Basque. & the reason a school can offer that class is because THEY HAVE A ROMANCE LANGUAGES DEPARTMENT.

13.08.2025 22:44 ๐Ÿ‘ 321 ๐Ÿ” 60 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 0