2️⃣ Data Scientist: Build and apply multimodal analysis pipelines to link in vivo functional properties, gene expression, and connectivity of single neurons.
We welcome applicants from neuroscience, computer science, or related backgrounds. With or without a PhD!
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📢 We are hiring! My lab at @crick.ac.uk has TWO open positions. Come work with us on visual processing and neural circuits!
1️⃣ Postdoctoral Fellow: Lead a project studying how cell types decode the 3D location of visual cues, combining multiphoton calcium imaging with molecular connectomics.
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Banner and confirmed speakers for Senses in Motion 2026 conference
One week left to submit an abstract to Senses in Motion 2026!
It's bound to be an exciting meeting with an excellent line-up of speakers! Please join us!
More details and registration link at 👇
sensesinmotion.org
Honoured to receive this grant from @erc.europa.eu to investigate how different types of neurons in the visual cortex solve this fundamental challenge of vision.
I'm incredibly grateful to my lab members, past and present, and colleagues and collaborators at @crick.ac.uk and beyond.
Registration for the 3rd Senses in Motion meeting taking place 18-21 May in Berlin is now open! If you work on sensation in freely moving animals and would like to participate, submit an abstract by Dec 19!
sensesinmotion.org
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The Crick is hiring Early Career Group Leaders!
Core funding for PhD studentships, postdocs, and staff scientists, phenomenal facilities and a wonderful community of early career GLs!
Please share widely and feel free to get in touch with any questions!
www.crick.ac.uk/careers-stud...
We are looking for a postdoctoral fellow to join the lab to study how cortical microcircuits are organised at the single cell level using high throughput molecular methods. Please share and get in touch if interested!
www.crick.ac.uk/careers-stud...
Applications for Doctoral Clinical Fellowships at the Crick, including a project in my lab, are now open! Please share widely!
We use high refresh rate "gaming" monitors to present closed-loop visual stimuli with low latency. They have various "gaming modes" and response time options that are poorly documented. So @antblot.bsky.social tested every possible setting to find out what they do.
znamlab.org/hardware-con...
How does the brain blend what we see with what we hear? In collaboration with @flor-iacaruso.bsky.social lab, we find new anatomical and functional rules that govern how auditory and visual cortices talk to each other.
Led by @alexegeaweiss.bsky.social & @bturner-bridger.bsky.social.
One way - it detects inputs of the starter neurons.
6/ As BRISC does not depend on the availability of transgenic animals, it is readily applicable across brain areas and species to systematically investigate how microcircuit organization varies across the brain and the evolutionary tree.
Preprint at www.biorxiv.org/content/10.1...
\5 Long-range inputs onto single V1 neurons reveal the topography of feedback projections from higher visual areas, which mirrors the retinotopic organisation of the visual cortex.
Reconstructed connectivity matrices of excitatory and inhibitory neurons.
4/ We apply BRISC in the mouse primary visual cortex, mapping 7,814 putative synaptic connections of 385 starter neurons and identifying layer- and cell-type-specific connectivity rules.
An animation showing presynaptic subnetworks of several example neurons.
3/ Barcodes are read out from intact tissue sections using in situ sequencing, thus reconstructing presynaptic ensembles of individual starter neurons while preserving spatial information.
Schematic explaining the workflow of BRISC. Starter neurons are defined by AAV injection and infected by barcoded rabies viruses. The barcodes are then transmitted to their presynaptic inputs. Connections are identified by matching barcodes between presynaptic and starter cells using in situ sequencing.
2/ BRISC uses random molecular barcodes transsynaptically transmitted by rabies viruses to map inputs of many neurons simultaneously, while maintaining single cell resolution. Connections between individual neurons are then identified by matching their barcode sequences.
1/ Mapping synaptic connectivity between individual neurons is extremely laborious. We developed BRISC, a new method that makes it possible to map inputs onto 100s of neurons in the same animal in a matter of weeks! Led by Alex Becalick and @antblot.bsky.social. 🧵
www.biorxiv.org/content/10.1...
Agree. Cuts in UKRI funded PhD places, is about government funding and prioritisation. We need work force planning with joined up thinking
A PhD is not about an academic career, its an apprenticeship for the knowledge economy. "Europe's Silicon Valley" will not exist without PhDs
Save the date!
UK Neural Computation 2025 will be at Imperial College London
9 July: ECR day
10-11 July: main meeting
9 invited speakers, 4 talks from abstracts and many posters
Abstract & registration opening soon
Pls share!
neuralcomputation.uk
Interested in understanding how things work? In particular the tools you use to study the brain? Join us at TENSS 2025 where we brainstorm ideas, build and debug microscopes, electrophysiology and behavior rigs amidst the picturesque Transylvanian hills! tenss.ro
Apply by: February 16th!
📢 If you are at #SfN2023, check out the lab's posters from Yiran He (Sun AM) and Alex Becalick (Mon PM)! I'll be around as well, so send me a message if you'd like to meet and catch up! #SfN23
We're hiring - a lab tech and fully funded (UK rate) PhD student! Join us at to figure out how the brain constructs auditory space! Adverts here (tech : shorturl.at/hmrFY) and here (PhD studentship : shorturl.at/adoJN). #neuroscience #hearing
Image of barcoded neurons distributed across a section of the neocortex.
🚀 Don't miss your chance join @thecrick.bsky.social PhD programme, including projects in my lab! Interested in how neuronal activity, connectivity and gene expression all relate to each other in vivo?
Learn more and apply at crick.ac.uk/careers-stud...
🗓️ Deadline Nov 9! Please repost!
Mouse cortical neurons have ~5,000 spines, but how many different presynaptic cells do they get input from? What is the average number of synaptic contacts between connected neurons in the mouse neocortex? I was hoping that there is a good estimate based on EM but I cannot find one.
Wow! End of an era indeed! Once a few years ago I tried to crossreference the timing of your and BGB's tweets but there was no clear signal.
ICYMI for neuro Twitter expats, a long standing mystery is solved.
Delighted to see this in print from my @TheCrick colleagues in Jonny Kohl's lab
How pregnancy (in mice) changes the behaviour of a population of hypothalamic neurons & initiates parental behaviour before birth
www.science.org/doi/10.1126/...
(3) We are also looking for a Doctoral Clinical Fellow to join us to map synaptic connections in human brain tissue using high throughput molecular methods, in partnership with Dimitri Kullmann at UCL:
www.crick.ac.uk/careers-stud...
(2) Joint studentship with Laura Andreae at KCL to understand mechanisms of development of corticocortical connections:
www.crick.ac.uk/careers-stud...
Multiple opportunities for PhD projects in my lab at the Francis Crick Institute starting in 2024! The Crick is an incredible place to do science! Please repost!
(1) Mapping neocortical circuits using high throughput molecular connectomics and in vivo imaging:
www.crick.ac.uk/careers-stud...
