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Pavitra Roychoudhury

@pavitrarc

Bioinformatics, viral evolution, math models | UW / Fred Hutch | Loves science, gizmos, silly jokes, dogs | ๐Ÿ‡ฎ๐Ÿ‡ณโ†’๐Ÿ‡ณ๐Ÿ‡ฌโ†’๐Ÿ‡ฌ๐Ÿ‡ญโ†’๐Ÿ‡ธ๐Ÿ‡ฌโ†’๐Ÿ‡บ๐Ÿ‡ธ

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11.11.2024
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Latest posts by Pavitra Roychoudhury @pavitrarc

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Fresh conflicts erupt around giant database for flu and COVID-19 sequences Critics say โ€œautocraticโ€ behavior by GISAID could hamper response to a future pandemic

โ€œ[P]utting data into GISAID is like dropping it in a mail slot in an unmarked building,โ€ says @colincarlson.bsky.social. โ€œItโ€™s wonderful that thereโ€™s so much cool stuff in that building. It would be great if we knew who owned it, or who paid for it, or what they plan to do with it.โ€
#IDsky ๐Ÿงช

07.01.2026 09:51 ๐Ÿ‘ 49 ๐Ÿ” 19 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 4

Also ironic that GISAID itself scrapes data from public databases like Genbank without proper attribution. Thanks for covering this.

08.01.2026 13:57 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5

06.11.2025 21:46 ๐Ÿ‘ 129 ๐Ÿ” 77 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 16
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๐Ÿ˜

07.11.2025 20:16 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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dplyr but make it bussin fr fr no cap `genzplyr` is an alternative syntax for `dplyr` that replaces boring old function names with GenZ slang. Your data wrangling is about to hit different.

Love this so much @hadley.nz

hadley.github.io/genzplyr/

07.11.2025 20:16 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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First locally acquired U.S. cases of more severe mpox strain reported โ€” CBS News California health officials have reported two cases of a potentially more severe form of mpox that appear to be locally acquired.

apple.news/AfbRCeaNOR_q...

17.10.2025 19:59 ๐Ÿ‘ 1 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Ousted CDC vaccine adviser says RFK Jr.'s message is clear: โ€˜Scientific expertise is no longer of useโ€™ Terminated CDC vaccine adviser Helen Chu spoke with STAT about her fears for the future of vaccine policy

Helen Chu is one of the ousted #ACIP members. She spoke to me today about her grave concerns for future vaccination policy and vaccine access in the United States. www.statnews.com/2025/06/10/c...

11.06.2025 01:32 ๐Ÿ‘ 1243 ๐Ÿ” 539 ๐Ÿ’ฌ 22 ๐Ÿ“Œ 27

Amazing! Congrats!

24.05.2025 15:41 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Ambitious project to develop low-cost genome sequencing for pathogens known and unknown - University of Birmingham Project will build on research that helped diagnostic labs to adopt sequencing capacity for COVID-19 and permit characterisation of future infectious threats

Absolutely thrilled to announce the launch of ARTIC2 - a ยฃ5.5M 5 year project funded by @wellcometrust.bsky.social to build on the ARTIC approach of low-cost, globally accessible genome sequencing for surveillance of outbreaks, epidemics and endemic diseases: www.birmingham.ac.uk/news/2025/am...

22.05.2025 10:57 ๐Ÿ‘ 229 ๐Ÿ” 80 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 4
Cover of Emerging Infectious Diseases journal. https://wwwnc.cdc.gov/eid/articles/issue/31/13/table-of-contents

Cover of Emerging Infectious Diseases journal. https://wwwnc.cdc.gov/eid/articles/issue/31/13/table-of-contents

The May 2025 supplemental issue of Emerging Infectious Diseases journal is now live: โ€œAdvances in Pathogen Genomics for Infectious Disease Surveillance, Control, and Prevention.โ€
wwwnc.cdc.gov/eid/articles...

16.05.2025 01:14 ๐Ÿ‘ 40 ๐Ÿ” 12 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1

1/ How has H5N1 affected this yearโ€™s flu season in Seattle? Despite ongoing outbreaks in birds & cattle nationally, we detected zero H5N1 cases in 675 influenza A-positive specimens tested at UW Medicine.

19.03.2025 14:20 ๐Ÿ‘ 7 ๐Ÿ” 2 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 1
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Validation of H5 influenza virus subtyping RT-qPCR assay and low prevalence of H5 detection in 2024-2025 influenza virus season A sustained outbreak of H5N1 influenza virus among wild fowl and domestic livestock has caused more than 70 zoonotic infections in humans in the United States, including one death. The Centers for Dis...

6/ Read more in our manuscript from the
Greninger Lab
at UW Virology
: medrxiv.org/cgi/content/.... Many people contributed to this work, including
@margaretgracemills.bsky.social, Ailyn Perez-Osorio, and
@pavitrarc.bsky.social.

19.03.2025 14:22 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Iโ€™m so tired of hearing Rubio & other rightwingers now claiming that if youโ€™re on a green card youโ€™re a โ€˜guestโ€™ in this country. BS. Youโ€™re a lawful permanent resident. The clue is in the name. If someone is a permanent resident in your home, are they the same as the guests who come and go? Come on.

16.03.2025 15:26 ๐Ÿ‘ 27398 ๐Ÿ” 5591 ๐Ÿ’ฌ 779 ๐Ÿ“Œ 181

Grateful to my amazing colleagues and coauthors for contributing to this work. And our collaborators across the pond who generously shared early versions of the ARTIC primers. /end

28.01.2025 19:05 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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tl;dr The assay shows robust performance across a range of viral loads allowing sensitive recovery for RSV genomes from clinical specimens. Its sensitivity makes it suitable for use in clinical trials of antivirals and vaccines allowing early detection of treatment emergent/resistance mutation. 4/

28.01.2025 19:05 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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We determined assay sensitivity, specificity, repeatability and reproducibility; and comparison with Sanger, shotgun, and capture-based sequencing methods to check for accurate recovery of the F gene. We also used contrived samples to determine the LOD of minor variants in allelic mixtures. 3/

28.01.2025 19:05 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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We modified 2 ARTIC primers based on initial tests with samples from USA (WA state), but changes are likely improve performance in global isolates based on current variation at those sites. We were able to recover high quality genomes from clinical samples with a wide range of Cts (95% LOD Ct 30) 2/

28.01.2025 19:05 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Happy to share our latest preprint describing clinical assay validation for RSV whole genome sequencing using a modified version of the ARTIC RSV panel doi.org/10.1101/2025... <thread> 1/

28.01.2025 19:05 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Excited to be involved in this study led by Helen Chu as part of the CDC's CHARM network tracking the spread of respiratory viruses across the US.

10.01.2025 05:09 ๐Ÿ‘ 2 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

My brain as soon as it saw this pop up on my feed: "In the shuffling madness of the locomotive breath" ๐Ÿš‚

My dad introduced us to Jethro Tull, listening to these on audio cassettes in the car. Love every single song.

01.01.2025 08:59 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
A group of school children sit in front of an orange truck which is a plow/sander. They are holding up a hand-drawn sign which I can't read but I think it says THANK YOU

A group of school children sit in front of an orange truck which is a plow/sander. They are holding up a hand-drawn sign which I can't read but I think it says THANK YOU

New names for Vermont snow plows 2024, selected by Vermont schoolchildren. Some selections...

Skibidi Scooper
No More Mr. Ice Guy
The Snowy Pl-Owl
Clearopathra
Snoah Kahan
Salt-O-Saurus

vtrans.vermont.gov/name-a-plow

16.11.2024 20:26 ๐Ÿ‘ 1542 ๐Ÿ” 366 ๐Ÿ’ฌ 56 ๐Ÿ“Œ 119

I think you probably meant this Evan Newell--I don't think he's on bsky.

www.fredhutch.org/en/faculty-l...

12.11.2024 17:51 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0