Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation - Nature Microbiology Inactivation of chromosomal genes through plasmid-encoded IS elements is an extended mechanism of antimicrobial resistance evolution in bacteria.

Final version of our last paper is out!
www.nature.com/articles/s41...

Saskatchewan Book Awards Announces 2026 Shortlist Regina & Saskatoon, SK — March 6, 2026 - Saskatchewan Book Awards Saskatchewan Book Awards recognizes and celebrates excellence and diversity in Saskatchewan writing and publishing.

We are pleased to have two books shortlisted for the 2026 Saskatchewan Book Awards! Elizabeth Quinlan for Standing Up to Big Nickel: The Story of the Mine, Mill, and Smelter Workers Strike & Bohdan Kordan for No Place Like Home: Enemy Alien Internment in Canada during the Great War.

Single-cell RNA-seq reveals a persistent interferon signature in immune cells from Systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment https://www.medrxiv.org/content/10.64898/2026.03.12.26348018v1

Quercetin and 6-Br_uercetin antioxidant properties and off target screening results advance glycosylated 6BrQ as a development candidate for Alzheimers disease https://www.biorxiv.org/content/10.64898/2026.03.10.710855v1

Bacterial CipB is an exogenous receptor to drive the #mitophagy-TFEB axis and promote pathogenesis. From Shuai Liu, Shan Li and colleagues (Huazhong Agricultural University): rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - Nature Cell Biology After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out

thttps://www.nature.com/articles/s41556-025-01856-x

Spicy Tuna Tartare in Sesame Miso Cones Recipe (with Video) • 1 ½ hrs, plus at least 12 hrs’ chilling Wolfgang Puck first served spicy tuna tartare at his Los Angeles restaurant Spago in 1998 and it’s become one of his signature dishes Seasoned with soy sauce, wasabi, Sriracha and mayonnaise, the tuna gets tucked into savory-sweet cones to serve at the annual post-Oscars Governors Ball party, which Wolfgang Puck has catered since 1994 They can also be successfully made at home for your Oscars watch party

Wolfgang Puck first served spicy tuna tartare at his Los Angeles restaurant Spago in 1998 and it’s become one of his signature dishes. Here's how to make it yourself at home: nyti.ms/4upnIYY

The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, co...

#NatMicroPicks

A Microbial Atlas 🦠🗺️

MicrobeAtlas unifies >2 million microbiome samples into a resource that enables consistent cross‑study comparisons and ecological contextualization of both known and newly discovered species.

#MicroSky #MicrobiomeSky

www.cell.com/cell/fulltex...

Anthropic’s Pentagon Battle Matters to Every Business The designation of the artificial-intelligence company as a supply-chain risk puts every business at the mercy of President Trump’s political priorities.

The designation of artificial-intelligence company Anthropic as a supply-chain risk puts every business at the mercy of President Trump’s political priorities, Greg Ip writes.

Decoding Covert Human Attention in Multidimensional Environments In complex environments, available information does not uniquely define state, requiring attention learning to identify features relevant for learning and decision-making. As a result, human decisions often reflect reasoning that cannot be directly observed from choice. This dual opacity, at the level of agent and observer, poses a fundamental challenge for understanding naturalistic behavior. We inferred latent attention during learning and decision-making by training recurrent neural networks on synthetic data generated from two classes of attention learning models: feature-based reinforcement learning (FRL), in which attention emerges through retrospective value updating, and serial hypothesis testing (SHT), in which discrete hypotheses are prospectively sampled. A network trained on hybrid (FRL+SHT) synthetic data outperformed single-model networks, decoding latent human attention with more than 80% accuracy. This work provides a new approach for decoding latent attention and suggests a mechanism of attention learning wherein value-derived hypotheses are continuously tested against incoming evidence.

Decoding Covert Human Attention in Multidimensional Environments bioRxivpreprint

Evolutionary dynamics of sex determination in Branchiostoma belcheri driven by repeated transposition of a single novel gene | Nature Communications Sex determination systems display striking evolutionary flexibility, yet the mechanisms underlying their transitions remain poorly understood. Using newly generated genome assemblies, we investigated the evolving sex-determining system in the amphioxus Branchiostoma belcheri. We identified two female-specific sex-determining regions (SDRs) on chromosome 13, both derived from independent transpositions of the autosomal gene tesD, which shows testis-specific expression in amphioxus species. CRISPR/Cas9 knockout experiments in Branchiostoma floridae confirmed that tesD functions as a male-determination gene, with loss of function producing an all-female phenotype. In B. belcheri, the older SDR (tesDwa) inserted into the coding region of twai, while the younger SDR (tesDwb), flanked by active Zator-1 transposons, inserted into the 3′ UTR of vps9c and later translocated to autosomes in ~10% of individuals. Transcriptomic analyses revealed that W-linked tesDwa and tesDwb produce antisen

Study reveals sex determination in Branchiostoma belcheri evolves via tesD gene transposition on chromosome 13. Fascinating insights! PMID:41530154, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-68322-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore sugarcane's complexity: 9-genome pangenome graph, 47-57 haplotypes/chromo, 74K-271K alleles. Revolutionizes multiomics! PMID:41643009, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adx1616 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

THY1⁺ CSCs drive metastasis via a pseudohypoxic state. Key roles: IL-6-MYC signaling, neutrophil mitochondria. Multi-omics reveal! PMID:41680445, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-01876-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects | Genome Biology | Springer Nature Link CRISPR/dCas9-based epigenome editing systems, including DNA methylation epimodifiers, have greatly advanced molecular functional studies, revolutionizing t

CRISPR/dCas9 epigenome editors show complex on-target and off-target effects, prompting better design for precision. Optimization is key! PMID:41620608, Genome Biol 2026 @OTSociety @NAR_Open https://doi.org/10.1186/s13059-026-03967-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A man in his 30s with 2-month scalp and lateral eyebrow hair loss. Negative hair-pull test. Diagnosis? Share thoughts! PMID:41671003, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2025.5973 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

BAF phosphorylation is crucial for anchoring centromeric heterochromatin to the NE, affecting genome organization in eukaryotes. PMID:41569157, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag021 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Poxvirus M3.1 triggers an antiviral NF-κB response in human monocytes, revealing an effector-triggered immunity (ETI) pathway. Fascinating insight! PMID:41678605, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adw4937 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat alters fruit morphology and severely limits reproduction but not growth in a widespread urban weed. https://www.biorxiv.org/content/10.64898/2026.03.10.710864v1

Relatedly: Sam Altman once funded a study of universal basic income that showed as clear a success as all the other studies have shown. His response was to propose instead “universal basic compute,” which was free time with an LLM. Worth even more than money!

A Big Night Light in the Sky? Start-Up Wants to Launch a Space Mirror.

Tech folks really being pretty vexing today.

Yeah, if only there was another way to illuminate streets for first responders.

www.nytimes.com/2026/03/09/c...

A flying taxi crossed the Golden Gate. Could it soon take you from S.F. to Wine Country? A handful of Silicon Valley startups are betting that, within a few years, small electric planes could be a transportation mode of choice for well-heeled commuters in the Bay Area.

Just, I mean, come on.

www.sfchronicle.com/sf/article/f...

“.. There’s no point in deceiving ourselves: Trump now sounds little different than Vladimir Putin in how he justifies the conflict—and in how much power he has claimed for himself to dictate America’s participation in it.”

@sbg1.bsky.social
www.newyorker.com/news/letter-...

This is great news! Too few ML practitioners know what a gamechanger nbdev can be. Years ago at AMD I used nbdev (version 1?) to implement an early prototype of FSR4 realtime super resolution. It was self-explanatory (e.g. with diagrams showing examples of jittering and temporal super resolution)…

5 million deaths a year globally are attributed to lack of physical activity. Many countries have set policies to promote physical activity but never implemented them.
No improvement in >20 years!
3 new papers
nature.com/articles/s41...
nature.com/articles/s44...
nature.com/articles/s44...

A single course of antibiotics can have lasting effects on your gut microbiome, with changes that last well beyond 4 years. Three types of antibiotics stood out for their long term disruptive impact (3 at left, Figure)
nature.com/articles/s41...

What a study - nearly 15,000 people followed up 4-8 years after a *sole* antibiotic treatment and some *still* had disrupted gut microbiome diversity. Pretty incredible. We’ve always been taught that such disruptions are ephemeral.

#IDSky #MicroSky

Human touch
www.alphaomegaalpha.org/wp-content/u...

Aging, stress inside cells, and promoting cancer metastasis
www.nature.com/articles/s41...
AT4 is the effector of the integrated stress response, enriched in patients of advanced age with cancer and correlated with poor survival (Figure)

The Protein Data Bank (#PDB) has reached a new milestone: 250,441 entries in the archive, a record since its founding in 1971, all thanks to the efforts and contributions of the structural biology community.

⬇️ more ⬇️
www.wwpdb.org/news/news?ye...

#StructuralBiology

Papers are like buses... You wait for ages, then two come along at once.

Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!

www.nature.com/articles/s41...