In this #EditorsChoice, data from The Lund Lab show that CXCR6 promotes the adaptation of T cells as they engage antigen in tissue to increase the probability of survival, memory differentiation, and long-term residence.
๐ https://ow.ly/6fjA50Yn5zf
New paper out: HIF-1ฮฑ+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung
www.sciencedirect.com/science/arti...
Congrats, Carolyn! Looking forward to reading it.
๐ Jesse Mulder, new postdoc in our lab! Jesse completed his undergraduate studies @monashuniversity.bsky.social, Australia. After his Honours year, he investigated the regulation of plasma cell lifespan programming during his PhD in the lab of David Tarlinton. Welcome to www.schoberlab.de/team!
Thanks for highlighting our work!
True story.
Very nice work, congratulations! I thoroughly enjoyed this story when you presented it here in Erlangen last year. Do you happen to have an author's link for free access to the article which you can share?
1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism ๐ www.science.org/doi/10.1126/...
This is a nice contrast to all the awful behavior confirmed through the Epstein files. Proud of @jenlucpiquant.bsky.social & @seanmcarroll.bsky.social for picking up on the sexism & charlatanism right away.
Warum erinnert sich das #Immunsystem oft ein Leben lang an eine #Impfung? Forscher um @kischober.bsky.social von der @fau.de sind dieser Frage nachgegangen โ und liefern mit ihrer Studie eine klare Antwort.
Die Mitgliedschaft im Jungen Kolleg ist mit einem jรคhrlichen Stipendium in Hรถhe von 12.000 Euro verbunden. Wer berufen wird, ist als auรerordentliches Mitglied Teil der Gelehrtengemeinschaft der Akademie. Finanziert wird das Junge Kolleg vom Bayerischen Staatsministerium fรผr Wissenschaft und Kunst
Kollegiatinnen und Kollegiaten der BAdW
Zum 1. Mรคrz hat die BAdW vier neue Mitglieder in ihr #JungesKolleg aufgenommen:
Gerti Beliu
@uniregensburg.bsky.social, Gabriele Hierlmeier @uni-wuerzburg.de, Jacqueline Lammert @tum.de und Alex Plajer @unibayreuth.bsky.social
Herzlich willkommen in der BAdW!
Or have a listen to my convo with Tasuku Honjo & Pierre Golstein, whose labs discovered PD1 and CTLA4 respectively, and imagine a scenario where this is worked out with the current non-animal methods
www.embo.org/podcasts/fro...
Life Sciences Bridge Award โ the award for talented researchers in #lifeSciences: the Aventis Foundation Life Sciences Bridge Awards are endowed with a subsidy amount of 100,000 each. Guidelines and application at bridge.aventis-foundation.org Deadline: 30 April 2026
TRR 355 is hosting its 1st International Symposium ๐Panoramahotel Waldenburg
๐๏ธ June 15โ18, 2026
Speakers: Megan Levings, Eliane Piaggio, Markus Feuerer, Burkhard Becher, Ido Amit, Nicole Joller, Jose Alves-Filho, Alexander Rudensky, Oizhi Tang, Shohei Hori, Axel Kallies, Lucy Walker.
TOX has opposing functions in CD4 & CD8 T cells, driving exhaustion in the latter but promoting Th1 commitment in CD4 T cells that drive antitumor immunity and pathogenic autoimmune responses
www.nature.com/articles/s41...
@natimmunol.nature.com @mskcancercenter.bsky.social
The Microbe Atlas database paper is *finally* published! Out in @cellpress.bsky.social today:
www.sciencedirect.com/science/arti...
Superb review.
Interested in understanding how epitope recognition specificity is encoded in your TCR sequences? Try our new interactive page for building TCR specificity profiles on the TCR Motif Atlas: tcrmotifatlas.unil.ch/Building_mot....
Excited to announce the 1st International Conference on T cells in Health and Disease, a new conference series aiming to bring together T cell biologists across diverse areas, from fundamental biology through to clinical translation, and spanning infection, autoimmunity and cancer.
Thank you for highlighting our work!
Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory @natimmunol.nature.com
www.nature.com/articles/s41...
@yellow4flavi.bsky.social
Funding: #BMFTR, @dfg.de, @ekfstiftung.bsky.social, Horizon Europe (#Yellow4FLAVI). Thanks also to @badw.de
Participating institutions: @fau.de,
@tum.de, @dkfz.bsky.social, @helmholtzmunich.bsky.social, @leibniz-gemeinschaft.de (LIT Regensburg).
6/6
Unser Immunsystem kann sich oft ein Leben lang an eine Impfung erinnern. Doch woran liegt das?
Forschende der FAU und des Universitรคtsklinikums Erlangen haben herausgefunden, dass die jeweiligen Abwehrzellen frรผhzeitig in eine Art Standby-Modus schalten. (1/2)
www.fau.de/2026/02/news...
In Olympic terms, long-term immune memory depends less on sprinters โ and more on marathon runners.
This work was led by #womeninSTEM power: Sina Frischholz, Ev-Marie Schuster and Myriam Grotz.
5/6
This suggests that long-lived T cell memory in humans may depend on an early metabolic โstandby modeโ. In most immunogenicity studies after vaccination, we still pay little attention to T cells โ and almost none to the metabolic activity of T cell subsets. In the future, we may need to do so.
4/6
The cells that persist the longest are not the most metabolically active ones. Instead, already early after vaccination, a subset of naive-like memory precursors enters a metabolically quiescent state and relies almost exclusively on oxidative phosphorylation.
3/6
We took advantage of the yellow fever vaccine and quantified metabolic activity of antigen-specific CD8 T cells at the subset and single-cell level by measuring protein synthesis rates as a functional readout of metabolic flux โ from the acute response up to 26 years after vaccination.
2/6
