Yuji Fujimoto

東京に空が無いと智恵子が言ったそうだが、子供の頃から私には新幹線に乗ると雲が低くなるのが不思議だった。あどけない空の話である。

酎ハイの、というか、ウォッカのアルコールは現実の味がする。

bioRxiv: A specialized ARGONAUTE enables trans-species RNA interference in plant immunity (2026) Trans-species RNA interference (tsRNAi), in which plants produce small RNAs (sRNAs) to silence target genes in pathogens, has emerged as a promising strategy for disease control. However, whether tsRNAi constitutes an endogenous, regulated immune response remains unclear. Here, we show that ARGONAUTE10 (AGO10) plays a critical role in pathogen-induced tsRNAi. Loss of AGO10 in Arabidopsis abolished pathogen gene silencing during infection, leading to hypersusceptibility to oomycete and fungal pathogens. Importantly, AGO10 rapidly responds to pathogen infection through increased protein accumulation and re-location into discrete cytoplasmic condensates, thus promoting the production of trans-species sRNAs at the pathogen infection sites. This immune responsiveness relies on the N terminal intrinsically disordered region (IDR) of AGO10, which is responsible for sensing and responding to immune activation. Specific features in the IDR partitions AGO10 into two deeply diverged subgroups, AGO10a and AGO10b, with the immune responsiveness and defense function evolutionarily conserved in AGO10a but not AGO10b. Together, these findings establish tsRNAi as a bona fide, evolutionarily conserved immune response and position AGO10 as a signal-responsive hub linking pathogen perception to tsRNAi-based defense.

New Preprint: A specialized ARGONAUTE enables trans-species RNA interference in plant immunity (2026)

https://www.tsl.ac.uk/publications/164506

This is a very interesting paper on the novel functions and regulatory mechanisms of AGO10!
Where can I access the supplementary materials for this paper?

A specialized ARGONAUTE enables trans-species RNA interference in plant immunity https://www.biorxiv.org/content/10.64898/2026.02.18.706620v1

Plant Cell: Soybean RNA polymerases IV and V repress defense response genes and plant immunity (2026) Transposon silencing via RNA-directed DNA methylation (RdDM) is mediated primarily through 24-nucleotide (nt) small interfering RNAs (siRNAs) and two plant-specific RNA polymerases, Pol IV and Pol V. We generated and characterized RNA-interference (RNAi) lines targeting the largest subunit of Pol IV and Pol V and the second-largest subunit shared by Pol IV and Pol V in soybean. Our analyses showed that the canonical roles of Pol IV and Pol V in RdDM as described in Arabidopsis, whereby Pol IV produces 24-nt siRNAs and Pol V recruits siRNAs to homologous loci to trigger DNA methylation, are conserved in soybean. Our analyses also uncovered functions of Pol IV and Pol V in that they repress defense response genes en masse. These genes normally undergo RdDM and are silenced, but they are de-repressed when Pol IV and Pol V are knocked down. Furthermore, the de-repression of a set of defense-related genes channeled their RNAs into the RNAi pathway to produce 21-22-nt siRNAs. Knocking down Pol IV and Pol V either singly or together led to increased resistance against the oomycete pathogen Phytophthora sojae, suggesting that Pol IV- and Pol V-mediated gene silencing regulates plant immunity.

New Publication: Soybean RNA polymerases IV and V repress defense response genes and plant immunity (2026)

https://www.tsl.ac.uk/publications/163632

Plant-parasitic nematode microRNAs hijack plant AGO1 to induce host-cell reprogramming https://www.biorxiv.org/content/10.64898/2026.02.13.705329v1

An uORF-encoded mobile peptide sparks systemic stomatal immunity In Arabidopsis, the uORF-encoded long-distance mobile peptide USIC in pathogen-infected local leaves activates systemic stomatal immunity, leading to stomatal closure in uninfected distal leaves.

An uORF-encoded mobile peptide sparks systemic stomatal immunity

www.cell.com/cell/fulltex...

ビズリーチの最近のcm、転生して無双する系の見てられない感がある。

1月に聴くさよならのバズーカの素晴らしさ

キッシーもゲルも内心ホッとしとるんちゃうか。こんなん火中の栗どころじゃない。

An anti-aggregation region of the SGS3 N-terminal IDR is essential for secondary siRNA biogenesis https://www.biorxiv.org/content/10.64898/2026.01.02.697351v1

An anti-aggregation region of the SGS3 N-terminal IDR is essential for secondary siRNA biogenesis https://www.biorxiv.org/content/10.64898/2026.01.02.697351v1

チャッピーに盛岡弁を喋らせている事に母上が大ウケしていた。

超・掃除。

第22回（令和7（2025）年度）日本学術振興会賞の受賞者決定について｜日本学術振興会賞｜日本学術振興会 日本学術振興会賞

晝間さんだ！
おめでとうございます！

www.jsps.go.jp/j-jsps-prize...

哺乳類において、オスの生殖器と排出口が分離されていないことの意義が猛烈に気になってチャッピーに根掘り葉掘り聞いた。こういうこと聞いてもニヤニヤしないからコイツ良いやつ。

【⚠️津波警報】
北海道、青森県、岩手県に発表　ただちに避難 (23時23分現在)
weathernews.jp/news/202512/...

津波注意報から津波警報へ切り替えた沿岸は次のとおりです。
＜津波注意報から津波警報への切り替え＞
　北海道太平洋沿岸中部、青森県太平洋沿岸、岩手県

12月8日か。

実際に自分でAF3で遊んでみると、RNAにはTではなくUがあり、それはAだけでなくGとも噛み合うという基礎事項の重みをまざまざと見せつけられる。

AGO5 restricts virus vertical transmission in plant gametophytes The propagation of a viral infection from a host parent to its progeny is known as vertical transmission, or seed transmission in plants. It allows viral infections to rapidly spread locally via polle...

Preprint alert! It is my great pleasure to announce the first manuscript from the lab, a story that started @gmivienna.bsky.social and was mainly accomplished by the intrepid @gesahoffmann.bsky.social at @mpi-mp-potsdam.bsky.social. A brief thread with our findings
www.biorxiv.org/content/10.1...

m6AとCMVのやつ、ちょっと違うんではという気が

よきかな

New Article: "Pathogen-induced condensation of the guard cell RNA-binding protein SAIR1 fine-tunes translation for immunity" rdcu.be/eP4kN

SAIR1 forms phosphorylation-regulated condensates in guard cells, which link PAMP–MPK3/6 signalling to stomatal immunity.

なんでウチから読めない論文を引用せにゃならんのだ

プラスミドの設計図とか、配列の登録じゃダメなのかな。「で、どこに何挿れたの？」ってなることが多い。プライマーリストから逆算してガチャガチャ解読するのめんどい。

アダージェットって言ったのに麻辣なわけねぇだろ

Molecular 'switch' that controls aging of plant leaves discovered A joint research team has discovered a new molecular switch that determines when plant leaves begin to age. The research team has identified for the first time a new mechanism in which RNA made from the nucleus moves to chloroplasts and regulates the aging of plant leaves.

A newly identified molecular mechanism shows that nuclear RNA migrates to chloroplasts to regulate the timing of leaf aging, offering insights into plant development and crop productivity. doi.org/g98qfn

The nuclear transcription factor NFYA3_0 promotes MTA-mediated m6A modification of Potato virus Y genomic RNA to confer antiviral resistance in Nicotiana benthamiana #research #PlantCommunications cell.com/plant-commun...