🔬✊ One year later, we #StandUpForScience again.
Attacks multiply. Funding shrinks. But our determination doesn't.
Science isn't opinion, it's the foundation of democracy.
Institut Pasteur researchers are mobilizing. Join us.
#StandUpForScience2026 #ScienceMatters #ResearchMatters
This is why we need to study persistent infections beyond the primary diseases they cause.
www.sciencedirect.com/science/arti...
I aspire to exude as much confidence as this little Kinesin protein strutting along a microtubule while hauling intracellular cargo.
Look at that little guy go! 🔬🧪
🎙️R2D2-MH coordinator @thomasbourgeron.bsky.social and #cocreation member Stéf Bonnot-Briey participated in a radio broadcast on #Autism, discussing #cocreation, science, lived experience and #inclusion.
🎧 Recommended for French speakers: www.radiofrance.fr/franceinter/...
#HorizonEU #Resilience
[Resources]
#AlphaFold protein and PPI prediction databases
1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org
2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...
3️⃣ Human interactome prodata.swmed.edu/humanPPI
4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev
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Science is not truth.
Science is finding the truth.
When science changes its opinion, it didn't lie to you. It learned more.
Despite decades of intensive research, current approaches to treating #NeurodegenerativeDiseases only slow down the seemingly inevitable. Could recent data associating #vaccines with reduced risk of #dementia offer an unexpected beacon of hope?🧪 @sparrerlab.bsky.social
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
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No, DeepMind has not solved the protein folding problem.
#Alphafold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination.
Integrated structural biology at its best with fantastic talks in cryo-EM, NMR, and X-ray techniques
Also integration with other Instruct Centres, in this case Kay Grünewald Instruct-DE @cssbhamburg.bsky.social 'Conformational flexibility and molecular plasticity in herpesvirus entry and egress'
Vibrant color portrait of Jane S. Richardson, the visionary biophysicist and artist who revolutionized structural biology with her invention of ribbon diagrams. She gazes warmly at the camera with a bright, knowing smile that radiates quiet brilliance and decades of curiosity. Her silver-blonde hair woven with gentle waves. Large, elegant dangling earrings catch the light, and she wears a richly patterned brown blouse embroidered with intricate turquoise paisley motifs and delicate beadwork that echoes the molecular elegance she has spent her life depicting. Behind her floats a luminous, dreamlike backdrop of glowing molecular structures--interlocking hexagonal and ribbon-like forms in electric blues, teals, and greens--blending science and art in a single, living canvas.
Hand-drawn and hand-colored (by Jane Richardson) scientific artwork known as a Richardson ribbon diagram (or “ribbon model”), one of the iconic visual inventions of Jane Richardson that transformed the way we see and understand protein structures. A graceful, three-dimensional tangle of protein backbone ribbons twists and spirals through space, rendered in soft pencil lines and luminous watercolor hues. Smooth golden-brown coils represent α-helices that curl like elegant ribbons, while broad teal-green arrows trace the flat, pleated strands of β-sheets slicing through the molecule with directional purpose. Thin, looping golden threads connect the secondary structures, creating a delicate, almost dance-like choreography of biology’s hidden architecture. The entire form is framed by a simple olive-green mat and dark border, giving the drawing the quiet dignity of both fine art and precise scientific illustration—a timeless bridge between molecular reality and human imagination.
Jane Richardson was born #OTD in 1941
+ Developed the Richardson (ribbon) diagram to represent proteins' 3D structure (becoming a standard representation for protein structures)
+ MacArthur Fellow, 1985
+ Elected, Nat'l Academy of Sciences, 1991
+ President, Biophysical Society, 2012
#WomenInSTEM
Color photograph of Joan Steitz (Joan Argetsinger Steitz), the distinguished American molecular biologist and biochemist renowned for her groundbreaking discoveries in RNA biology, including the identification of small nuclear ribonucleoproteins (snRNPs) essential to RNA splicing. She is pictured in a close-up portrait within a laboratory or research setting, smiling warmly and directly at the camera with an engaging, approachable expression that conveys enthusiasm and expertise. Steitz has gray hair pulled back, striking blue eyes, and is wearing large, elaborate dangling earrings adorned with purple gemstones and metallic accents. She is dressed in a rich purple blouse. The softly blurred background includes scientific elements such as lab benches, equipment, monitors, charts, and partial signage, evoking the environment of her long career at Yale University where she served as Sterling Professor of Molecular Biophysics and Biochemistry. #JoanSteitz #MolecularBiology #WomenInScience #Biochemistry #RNA
Biochemist/molecular biologist Joan Steitz was born #OTD in 1941.
She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM
Have no fear if you weren't in the packed audience this week for @martinpacesa.bsky.social's awesome seminar, because you can check out the recording 👇
youtu.be/qQihl6If9vU
Huge congratulations @nboyd.bsky.social with Mosaic that absolutely killed in the competition! 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕2 did also pretty well with the second highest hit rate in the competition!
proteinbase.com/collections/...
Excellent overview of the (mind-blowing) effects of the Shingles vaccine against dementia by @erictopol.bsky.social Ground Truth 🧪 "Two new studies add to a remarkable body of evidence for benefit" ⬇️
open.substack.com/pub/erictopo...
"Not sure if _name_ (my husband) would be ok with this?" - answer from a PI to my suggestion to go to a month-long training outside of country.
"If Covid was a fire alarm, our response, incredibly, has been to rip out the wiring. Instead of correcting the underbuilt public health systems that allowed thousands to die in the dark, we are choosing to institutionalize blindness." 👇
www.statnews.com/2026/01/18/t... via @statnews.com
Published in Cell, a new study shows that the immune system’s reaction to the common Epstein-Barr virus can ultimately damage the brain and contribute to multiple sclerosis, from a team @ki.se
www.cell.com/cell/fulltex...
3 papers on EBV and MS
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS
www.cell.com/cell/fu...
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'But what if IAVs could use a different receptor? Our previous work revealed that the IAV subtypes H17N10 and H18N11, which have so far been detected exclusively in bats, use MHC-II molecules as entry receptors instead of the conventional sialic acid receptors'
Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info.
Deadline 8 Feb. Apply here:
umustipendie.varbi.com/en/what:job/...
#virus #virology #teamtomo #cryoEM
Wanting to do some paleovirology of your own? We recently published HI-FEVER, enabling users to run their own fast searches for endogenous viral elements.
Huge thanks to @humanceae.bsky.social, @emma-harding.bsky.social, José Gabriel and Cormac.
@biology.ox.ac.uk
academic.oup.com/bioinformati...
Here's a summary of all the data that supports adding more red meat to your diet
Given everything happening right now, I updated this article with options for weather apps, web forms, and translation services — along with some tweaks to existing categories.
I hope it helps your transition off US tech!
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
The EMDB wishes you a very Merry Christmas, a Happy New Year and we are delighted to share our jointly designed EMDB/PDBe Christmas card with you. It has been a busy year, we look forward to seeing you in the New Year here! Card: A mixture of #cryoEM and X-ray diffraction structures.
Seven feel-good science stories to restore your faith in 2025 www.nature.com/articles/d41...
Want to analyze the role of endogenous retroviruses in early human development or investigate their regulation in pluripotency and early development for your PhD?
Join the lab of @fueyoraquel.bsky.social via the IMPRS-BAC #gradschool!
👉 www.molgen.mpg.de/5094682/Fuey...
The decision by the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention to downgrade its recommendations to protect infants from hepatitis B is a dangerous move that will harm children.
Click here to read AAP's full statement: bit.ly/3Y9ZQJT
Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
