Swantje Lenz

Two-panel calibration plot (two benchmark dimer datasets) comparing predicted interchain contact-probability bins (x-axis) with the observed fraction of native interfacial contacts (y-axis). Points follow the diagonal, indicating close agreement between predicted probabilities and true interface-contact fractions.

My first manuscript in MPI colours! With @tothpetroczylab.bsky.social, we show that AlphaFold PAE-derived contact probabilities are well calibrated to the fraction of true interface contacts across experimentally determined protein dimers.

www.biorxiv.org/content/10.6...

Congrats Alison!

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Happy to share the first paper of my postdoc and happy to have been part of the team!

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...

a group of ducklings are running in a field . ALT: a group of ducklings are running in a field .

🍃CD-CODE update v1.09 is here!🍃

👀Check out the new #biomolecular #condensates at cd-code.org
👀We're continuing to update #Protein - #condensate connections and resolve issues!

Join us to share your #condensate #expertise as a contributor: cd-code.org/signup

#Bioinformatics #DatabaseUpdate #IDR

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...

PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms - Nature Communications Here the authors report PICNIC (Proteins Involved in CoNdensates In Cells), a machine learning algorithm that predicts approximately 40–60% of proteins form condensates in various organisms, showing n...

Our PICNIC tool predicts condensate-proteins regardless of their structural disorder across organisms @naturecomms.bsky.social. Congratulations to @annaha-poetry-art.bsky.social for developing the algorithm and to Hari
@hymanlab.bsky.social for the experiments! www.nature.com/articles/s41...