Meaghan Perdue

Research assistant job posting is live! Come join us in Calgary and be part of a supportive, interdisciplinary team.

careers.ucalgary.ca/jobs/1631661...

The future of pediatric brain research is here thanks in part to Brain Canada's critical platform support grant program!! C-PIP is uniting hospitals, researchers, and technology to transform child neuroimaging in Canada.

Read More: shorturl.at/KVwQi

Democratic Senator Chris Murphy on Mahmoud Khalil.

This work was done with fantastic colleagues @ucalgary.bsky.social @catherinealebel.bsky.social @bryce-g.bsky.social @kathrynmanning.bsky.social

Interaction plot showing association between age (x-axis) and arcuate fasciculus microstructural asymmetry (y-axis) moderated by decoding ability(color scale: lighter colors=better decoding scores). Fit lines show age-asymmetry association for poorer readers (purple long-dash), sample mean (solid magenta line) and better decoders (pink short-dash)

Post-hoc analysis showed marginal effects of microstructural lateralization, with better decoders showing leftward lateralization from early in development

Analysis included 280 dMRI scans from 66 English-speaking children, MRI acquired between ages 2-12, and reading ability assessed between ages 6-12. Most children performed in the average-above average range, with ~9% scoring below average, similar to population rates of reading disability.

Phonological decoding ability is associated with fiber density of the left arcuate fasciculus longitudinally across reading development Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but findings have been inconsistent and la…

Our new article shows that fiber density in the left arcuate fasciculus is consistently associated with phonological decoding ability, with better decoders showing greater fiber density even before learning to read. www.sciencedirect.com/science/arti...

SpEd teachers are the special forces of the education workforce. They have the highest level of skill/expertise in an incredible range of skills (behavior management, assessment, instruction, law/policy, etc.). We need more special education teachers, not less.

Findings have implications for understanding the roles of neural excitability and membrane metabolism in cognitive functioning in children with and without prenatal alcohol exposure #neuroscience #neuroskyence #psychscisky

scatter plots showing (A) the association between glutamate+glutamine (Glx) and inhibitory control indexed by the NEPSY-II Statue Total Scaled score: interaction effect shows a relation between higher Glx and poorer Statue scores in children with Prenatal Alcohol Exposure (shown in orange), but not unexposed children (shown in purple); and (B) the association between total choline (tCho) and overall executive functioning indexed by the BRIEF GEC T-score (higher T-scores indicate more difficulties with global executive functioning), children with prenatal alcohol exposure had higher BRIEF GEC T-scores than unexposed children, and higher tCho levels were associated with lower BRIEF GEC T-scores within both groups

Total choline in the anterior cingulate cortex (ACC) was associated with overall executive functioning in children with an without alcohol exposure, while glutamate+glutamine in the ACC was uniquely associated with inhibitory control in the alcohol-exposed group

Altered markers of brain metabolism and excitability are associated with executive functioning in young children exposed to alcohol in utero - Metabolic Brain Disease Prenatal alcohol exposure (PAE) is the leading known cause of birth defects and cognitive disabilities, with impacts on brain development and executive functioning. Abnormalities in structural and fun...

Now published open access - we found that total choline and glutamate+glutamine were elevated in children exposed to alcohol prenatally during early childhood. doi.org/10.1007/s110... with @catherinealebel.bsky.social

Scatter plots showing the association between metabolites (X-axes, left=Glx, right=tCho) and executive functioning (Y-axes, left=NEPSY-II Statue Total Scaled Score, right=BRIEF Global Executive Composite T-score). Panel A shows interaction by Alcohol Exposure group with negative effect in children with alcohol exposure. Panel B shows Main effects of higher BRIEF GEC T-scores (more difficulties with exeutive function) in the alcohol exposed group, and higher tCho is associated with better executive function in both groups

🚨New Preprint!🚨 doi.org/10.1101/2024... We found elevated choline and glutamate/glutamine in young children exposed to alcohol in utero vs unexposed children, and metabolite levels were associated with executive functioning indexed by parent report and a motor inhibitory control task

Amazing!

My department is recruiting at the junior level, area of expertise more or less open, contributing to the speech-language pathology program. I love working at UConn--great language science community, high quality of life. Come join us! jobs.hr.uconn.edu/en-us/job/49...