Dr. Caitlin Pepperell

And here jobs.ncl.ac.uk/job/Newcastl...

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

Colonies of the bacteria Gardnerella, strain 3336, grow on an agar plate and appear as large or small colonies (left panel). The number of Gardnerella surviving in an infection of huaman cervix tissue in the lab is depicted in a bar graph, and the number of small colony variants that survive is greater than those of the large colony variants (right panel).

🧪 We've published our first paper on Gardnerella. There is extensive phase variation in all the Gardnerella species we examined. It effects surface proteins, toxin production, and human cervix infection ex vivo. doi.org/10.1128/msph...

Also, non coding RNAs are important

Genetic background is key: 1) prior to selection, strains vary in how they respond to biofilm cues; 2) response to selection is shaped by ancestral haplotype (canalization)

Adaptation of the Mycobacterium tuberculosis transcriptome to biofilm growth Author summary Understanding mechanisms of resistance and tolerance in Mycobacterium tuberculosis (M. tb) can help us develop new treatments that capitalize on M. tb’s vulnerabilities. Here we used tr...

Hot off the press! Our research on transcriptome evolution of mega-pathogen M. tuberculosis: journals.plos.org/plospathogen...

aka what happens to the transcriptome when you select for biofilm growth?

Word cloud of research topics

Whoa. Redux of a paper from 12 years ago with the opposite effect: sweeps and persistence not brief perturbation 🧪🧬