Toward a toolbox of organic reductants⚗️ Mario P. Wiesenfeldt & co-workers @wiesenfeldtlab.bsky.social show how metal-free strategies enable predictable C–C bond reductions in complex, drug-like molecules💊
#organocatalysis
Read more 👉 buff.ly/OsDpegR
Discover a faster, solvent-free route to Boscalid⚗️ Hajime Ito @hajito1.bsky.social & co-workers report a rapid, scalable mechanochemical synthesis that cuts time, waste, and energy!
#mechanochemistry #SuzukiMiyaura
👉 buff.ly/XeOEaNs
Synthetic electrochemistry goes interfacial⚡This review by Jianchun Wang & co-workers explores how chemically modified electrodes—nanoparticle-based or catalyst-immobilized—unlock new reactivity, selectivity, and mechanistic insight in organic #electrosynthesis
Read more 👉 buff.ly/Lr2DimW
Azo-peptide synthesis by Oestreich @silicon-martin.bsky.social & co-workers — no stereochemical compromise✨Pd-catalyzed C(sp²)–N(sp²) cross-coupling enables epimerization-free installation of #azobenzene units onto amino acids and small #peptides
Read more 👉 buff.ly/DpAcyVM
Rearranging with precision🔄 Eiji Tayama & co-workers uncover how ring strain steers Sommelet–Hauser over Stevens #rearrangement, delivering enantio- and diastereopure α-arylamino acid amides via chirality transfer🧪
#ammonium
👉 buff.ly/kmwcrxm
Yu Zhao & Jun Xuan review how visible-light #photochemistry drives S–N bond cleavage to difunctionalize alkenes & alkynes, unlocking efficient routes to bioactive sulfur–nitrogen motifs💡
#radicals
👉 buff.ly/XSJznV0
✨Special Topic Dedicated to Prof. Knochel✨
A powerful photochemical coupling of aryl #azides & anilines delivers hard-to-access N-aryl-ortho-phenylenediamines via singlet #nitrene chemistry enabled by a Lewis acid💡Great work by Ruffoni & Leonori
#OpenAccess for a limited time 👉 buff.ly/yiR3P6O
🚀Explore the power of #photochemical #decarboxylation of dicarboxylic acids, unlocking alkyl radicals, arynes, strained cycloalkynes & more🌟 From unique intermediates to late-stage functionalization, this review by Lei Shi lights the way for future innovation
👉 buff.ly/Y9hPoG5
Join Thieme #Cheminar “Strain-Release Chemistry”🔬 with our speakers Dr. Durga Prasad Hari (🇮🇳), Prof. Jérôme Waser (🇨🇭) @lcsolab.bsky.social & Prof. Peter Wipf (🇺🇸), hosted by our assoc. editor Prof. Akkattu T. Biju
📅February 24, 2026
⏰11 AM (GMT+1)
👉 buff.ly/5WCuOFp
✨Special Topic Dedicated To Prof. Paul Knochel✨
Berionni & co-workers @dr-berionni.bsky.social report transition-metal-free #borylation of electron-poor arenes and polyaromatics using a 9-boratriptycene pyramidal boron Lewis #superacid💡
#OpenAccess 👉 buff.ly/eRLkiaG
Cracking the stereochemical code of insect #pheromones 🔍 The group of Stefan Schulz reports a simple, scalable route to both enantiomers of heptalactone. From Jacobsen’s Co-salen resolution to Grignard & PCC steps, they deliver a path to pure signals🐝
#semiochemicals
👉 buff.ly/Z5IxZlS
Selective Reductions of Complex Pyridines via NTf-Pyridinium Salts: www.thieme-connect.com/products/ejo... (@synthesis1969.bsky.social).
✨Special Topic Dedicated To Prof. Paul Knochel✨
Asymmetric Kumada–Tamao–Corriu coupling: Clavier @herveclavier.bsky.social & team show Pd(NHC) catalysts that afford axially chiral biaryls; steered by the ArylMg reagent and #NHC—not the aryl halide💡
#OpenAccess to the full issue 👉 buff.ly/KRqDfG7
✨Special Topic Dedicated To Prof. Paul Knochel✨
Late-stage modification is going sustainable🌿 Ackermann & team @catalysis-lab.bsky.social review how #electrochemistry replaces toxic oxidants with clean electrons (2019–2025)⚡️
#functionalization
#OpenAccess 👉 buff.ly/4O7s3Ig
Dive into steric chemistry✨ Mustafa Cetin reveals how bulky tert-butyl groups reshape α-diimine ligands, where sterics beat electronics, twisting structures and steering reactivity in Schiff bases⚛️
#hindrance
#OpenAccess 👉 buff.ly/C7CcRLd
⚡️A mild, metal-free electrochemical route to arylboronate esters! This decarboxylative #borylation by Xianqiang Kong & co-workers shows broad scope, great functional-group tolerance, and strong atom-economy♻️
#electrochemistry
👉 buff.ly/f4phiUs
✨Special Topic Dedicated To Prof. Paul Knochel✨
Dirk Trauner @dirktrauner.bsky.social & team use their synthetic azide-based platform to access loline analogues and explore loline as a bidentate ligand for Pd chemistry
#ClickChemistry
#OpenAccess for a limited time 👉 buff.ly/KRqDfG7
Synthesis of Transition-Metal–Boryl Complexes from Diboron Reagents (@synthesis1969.bsky.social): www.thieme-connect.com/products/ejo....
Diving into TM–boryl chemistry✨ Hairong Lyu & co-workers review transition-metal–boryl complexes from Fe, Co, Ni, Cu, Rh, Ir, Ru, and Pt, highlighting their formation from various diboron reagents, reactivity with alkenes/alkynes and roles in catalytic #borylation⚗️
👉 buff.ly/Yg2ixiU
✨Special Topic Dedicated To Prof. Paul Knochel✨
Exploring C–O bond #functionalization 🚀 This review by Seki & Nakao categorizes C(sp²) and C(sp³) activations, highlighting new #TransitionMetals and dual #catalysis strategies to break inert bonds⛓️
#OpenAccess for a limited time 👉 buff.ly/KRqDfG7
Controlling epoxide #cyclizations like never before🌀
Vanderwal & co-workers explore α-alkoxy #epoxides in Nugent–RajanBabu reductive cyclizations, revealing how α-oxygen protecting group size dictates 6-endo vs 5-exo outcomes⚗️
#TotalSynthesis
👉 buff.ly/XJnLZ1c
✨Special Topic Dedicated To Prof. Paul Knochel✨
Explore the first continuous-flow Reformatsky-type reaction via ethyl γ-bromocrotonate🚀 André B. Charette & team optimize γ-selectivity to synthesize homoallylic alcohols and #Piperine 🌿
#FlowChemistry
#OpenAccess for a limited time 👉 buff.ly/KRqDfG7
✨Special Topic Dedicated to Prof. Knochel ✨
Radical chemistry for remote C–C & C–heteroatom bond formation🔬 This review by Dagousset et al. highlights decades of advances in functionalizing α,β-unsaturated carbonyls🌟
#photocatalysis #organocatalysis
#OpenAccess for a limited time 👉 buff.ly/KRqDfG7
A mild & efficient route to trisubstituted methanes✨Waghmode & co-workers report a TFA-catalyzed, highly regioselective 1,6-addition of mercapto- and hydroxy-pyridines to para-quinone methides, offering broad scope and chromatography-free workup⚗️
#mercaptopyridine
👉 buff.ly/sOo9824
Quisqualic acid is an interesting non-proteinogenic amino acid with applications in medicinal chemistry. Have a look at our detailed account on its synthesis, which was just published in Synthesis @synthesis1969.bsky.social
www.thieme-connect.de/products/ejo...
✨Special Topic Dedicated to Prof. Knochel ✨
Self-assembling pyridone #phosphorus ligands🧩 Bernhard Breit & co-workers present 19 ligands, including 11 P-stereogenic versions with excellent ee and high thermal stability🔥
#catalysis
#OpenAccess for a limited time 👉 buff.ly/KRqDfG7
Michalak & Vanderwal report a clever, Cl-guided stereocontrolled formal synthesis of Steviol — using a removable chlorine center and epoxide-initiated bicyclization for precise stereochemistry🔄⚗️
#terpenoids #TotalSynthesis
👉 buff.ly/Q2ize6T
Explore the power of π–π #interactions ! Jeonghyo Lee & co-workers show how these forces guide chemo-, regio-, and stereoselective transformations in C–C, C–O, and C–N bond formation, plus selective reductions ⚗️
👉 buff.ly/r7n7m9d
We’re live!
Introducing Therapeutics NOW – Thieme’s new Gold Open Access journal driving breakthroughs in translational therapeutic research.
✅ Interdisciplinary by design
✅ Broad scope & impactful article formats
✅ Ultra-fast peer review via Select Crowd Review
🔗 www.thieme.com/en-us/thieme...
Alessandro Palmieri & co-workers present a practical #onepot route to 2,5-disubstituted thiophenes, using a base-promoted Michael addition followed by acid-driven cyclization. Efficient, elegant chemistry in action!⚗️
#thiophene #nitroalkenes
👉 buff.ly/kr1FKgp
