@walterwchen
Postdoc in Ralph DeBerardinis' Lab and Neonatologist at UT Southwestern (UTSW) via Harvard/MIT MD-PhD, Harvard Pediatric Residency, UTSW Neonatology Fellowship | STAT Wunderkind, ASCI E-Gen Award, BWF CAMS Studying #metabolism, #mitochondria, #peroxisomes
My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology!
We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior.
Come do cool science with me!
lnkd.in/gKEXWUGy
Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
Big Congrats to @zhengwu1.bsky.social and Phong Nguyen on this beautiful work!!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Ty Tech Networks for the invite! @cri-utsw.bsky.social @rjdlab.bsky.social www.technologynetworks.com/proteomics/o...
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦
Beautiful work as usual Kara!! Fascinating and exciting study! 💪🏻
Lab’s 1st preprint!
Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.
@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.
He is on the job market!
Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...
Congrats Isha!! 🎉👏🏻
Leveraging modern scientific tools and techniques, @ishahjain.bsky.social intends to transform our understanding of the critical roles that vitamins play in health and disease.
Excited to present my research at the upcoming University of Utah Rising Stars Symposium and meet fellow scientists who love metabolism! @cri-utsw.bsky.social @rjdlab.bsky.social
Big congrats and welcome! Looking forward to seeing you around campus and your future science!
Excited to share that I’ve started my lab as an assistant professor at the University of Texas Southwestern Medical Center in Dallas.
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...
Happy to share our new paper in @nature.com led by staff scientist Xuejing Liu. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
www.nature.com/articles/s41...
Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years.
🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!
I am excited to share my graduate work in the Sabatini and @bartellab.bsky.social labs. Since their discovery, we have known lysosomes possess RNase activity; however, their substrates were not known. Surprisingly we find specific RNAs are targeted for degradation! www.biorxiv.org/content/10.1...
Woo!! Congrats Zheng!! 🎉🎉
🍹 @walterwchen.bsky.social et al show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins.
bit.ly/4lmjv2l
Big congrats Nick!!! 🎉🎉
I’m really beyond thrilled to be included in this years Pew Biomedical Scholars cohort and to be able to meet all the incredible scientists in this program. I was in Scott Kennedy’s lab when he was a Pew Scholar and never thought I’d be lucky enough to also be one! www.pew.org/en/about/new...
Happy to announce that I was awarded a pathway to independence award (K99) from the NCI/NIH today to work on studying whole-body metabolism driving cancer cachexia. None of this would be possible without support from @damonrunyon.org, @transactivator.bsky.social and @mvhlab.bsky.social.
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
I’m extremely honored to be recognized with the WICB Junior Research Award. ASCB and WICB have been key to my career development since I attended my first annual meeting in 2005. Congrats to the other awardees!
A new tragedy for the Endocrine community An outstanding scientist leaves us too soon
I am unspeakably humbled and grateful for this honor - to "wear" Goeddel's name is simply insane. I can only promise to do my best to do it justice.
ONWARDS!!!
Our lab has derived over 50 trophoblast organoid lines to better understand how chronic conditions like hypertension and obesity influence placental development and metabolism. (Check out this figure made with @biorender.bsky.social)