The French Purine Club

Great news for the #purinergic community! 📢

Abstract submission for the 3rd European Purine Meeting (Bordeaux, 1–3 July 2026) has been extended until March 31.

📝 Don’t miss the chance to present your work!

We look forward to welcoming many of you in Bordeaux.

@neuropursignal.bsky.social @univbordeaux.bsky.social
@ignaciospizarro.bsky.social @ischemia1327.bsky.social
@thibaut14e.bsky.social @isabellearnoux.bsky.social @bouegrabot.bsky.social

📢 Save the date! 3rd European Purine Meeting
🗓️ 1–3 July 2026 |
📍 Bordeaux, France (Univ. Bordeaux, Campus Victoire)

Preceded by the final PRESTO meeting: 30 June–1 July 2026
🌐 Call for Symposia now open: live.eventtia.com/en/european-...

#P1 #P2X#P2Y #ATP #adenosine #purinergic #signalling

@neuropursignal.bsky.social @bouegrabot.bsky.social @univbordeaux.bsky.social @ignaciospizarro.bsky.social @ischemia1327.bsky.social @riekjewinzer.bsky.social @thibaut14e.bsky.social @isabellearnoux.bsky.social

Neuroscientifiques en France, on a besoin de vous !

La Société Française de Neurosciences lance un questionnaire pour dresser un panorama de notre communauté et orienter ses actions futures.
👉 10 min max : psychology.eu.qualtrics.com/jfe/form/SV_...
#neurosciences #recherche

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase

www.science.org/doi/10.1126/...

Our editorial article published today @FrontiersIn closes the ResearchTopic: Purinergic signaling function in the #CNS in health and #diseases with 22 articles thanks to my co-editors and 145 contributing authors. #P2X #Adenosine #P2Y Front.Cell.Neurosci|

doi.org/10.3389/fncel.…

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF

The next European #Purine Meeting will be hosted by the French Purine Club in Bordeaux in 2026 with the important support of the EU COST Presto coordinated by Prof. Elena Adinolfi.

The French Purine Club is present at the World Congress on Purines 🇨🇳

Discovery of a 2′-α-Fluoro-2′-β-C-(fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent A novel 2′-α-fluoro-2′-β-C-(fluoromethyl) purine nucleoside phosphoramidate prodrug 15 has been designed and synthesized to treat SARS-CoV-2 infection. The SARS-CoV-2 central replication transcription...

A study by researchers in China introduced a new purine nucleotide prodrug targeting SARS-CoV-2.

Tested on rats, the oral drug showed strong antiviral activity, safety at high doses, and lung-targeting efficacy.

pubs.acs.org/doi/10.1021/...

The French Purine Club is present at #Glia2025 #Marseille

A great first scientific day of the French Purine Club at ESPCI ! #FPC2025

Members of INSERM UMR1327 Ischemia: Mohammed ELMALLAH, Marylou PICHONNIERE and Oumnia BENOUNA were pleased to present their work yesterday, at the Annual meeting of the @frenchpurine.bsky.social in Paris. A meeting enriched by relevant scientific discussions.

Karine Massé (Université de Bordeaux, IMN CNRS UMR5293)
"Eye and kidney embryonic development regulation: Role of alkaline phosphatase alpl"
👁️🩺 Linking ALPL to organogenesis via purinergic control.
#FPC2025 #DevelopmentalBiology

David Blum (INSERM UMR-S1172, Lille) -le vrai -.
"Adenosine A2A receptor in astrocytes triggers multicellular dysfunction in Alzheimer’s Disease"
🧠 From glial dysregulation to network-wide pathology and neuronal hyperexytability
#FPC2025 #AlzheimersResearch

Anne-Sophie Rolland (Lil'N'Cog, INSERM UMR-S1172, Lille)
"Newly diagnosed ALS patients may benefit from regular caffeine consumption" well her liming!
☕ Could coffee slow ALS progression?
#FPC2025 #Neurodegeneration #ALS #Neuroprotection

Solène Rimbert (ESPCI, CNRS UMR8249)
“The role of adenosine A2A receptor in the stabilisation and elimination of glutamatergic synapses”
#FPC2025 #A2a #development

Elena Dossi (Collège de France, INSERM U1050)
"Differential contribution of astroglial connexins to chronic seizures in mice and humans: a role for ATP?"
⚡ ATP as a hidden player in astroglial communication and epileptogenesis.
#FPC2025 #Neuroglia #Epilepsy #Astrocytes

Sara Carracedo (Université de Bordeaux)
"P2X4 receptor modifies lysosomal properties and autophagy in microglia"
P2X4 increases lysosomal size while decreasing their number
#FPC2025 #Neuroinflammation #Microglia #Lysosomes

Oumnia Benouna (Université de Tours)
"P2X4 modulates autophagy in renal tubular cells under ischemia-reperfusion"
🧪 New insights into P2X4's role in cell survival.
#FPC2025 #KidneyResearch #Autophagy #RenalCells

Thomas Grutter (Université de Strasbourg)
"New labeling method for revealing endogenous P2X7 at single-molecule level in BV2 microglia"
🔍 Cutting-edge imaging meets purinergic biology.
#FPC2025 #Neuroimaging #P2X7 #SingleMolecule

Marylou Pichonnière (UMR1327 ISCHEMIA, Tours)
"Extracellular nanovesicles as potential biomarkers of kidney-graft function recovery"
📊 EVs as a non-invasive window into renal recovery.
#FPC2025 #Transplantation #Biomarkers #P2X4 #P2X7 #KidneyTransplantation

Mohammed Elmallah (Inserm UMR1327, Tours)
"Immunomodulatory effects of breast cancer MDA-MB-231- cell-derived extracellular vesicles on monocyte-derived dendritic cells: Implication of P2X4 purinergoc receptor"
#FPC2025 #PurinergicSignaling | #BreastCancer #Immunomodulation

Valérie Vouret-Craviari (IRCAN, Nice)
"Expression of purinergic checkpoints in response to treatments in lung cancers"
💡 Toward a personalized medicine including modulators of purinergic checkpoints
#FPC2025 #CancerImmunology
#PurinergicCheckpoints

Kicking off the 3rd Annual French Purine Club Meeting in Paris,
David Blum, President of the Club, welcomes researchers to two days of cutting-edge insights on purinergic signaling in health and disease.
📍Live from ESPCI – Let the science begin!
#FPC2025

📢 Scientific Program Now Live | #FPC2025
From purinergic checkpoints in cancer to ATP signaling in neurodegeneration, the 3rd Scientific Days of the French Purine Club bring cutting-edge talks across immunology, oncology & neuroscience.
📍June 30–July 1 | ESPCI Paris

3e Journées Scientifiques du French Purine Club ESPCI, 10 rue Vauquelin, 75005 Paris

Nous avons le plaisir de vous inviter aux 3ᵉ Journées Scientifiques du French Purine Club !
📅 30 juin à 14h au 1er juillet à 12h
📍 ESPCI, 10 rue Vauquelin, 75005 Paris
🔗 docs.google.com/forms/d/e/1F...

💡 Pensez aussi à votre cotisation annuelle
➡️ bit.ly/4hOcar6

Nous espérons vous y voir nombreux !

We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.