Kutay lab

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

We are delighted by the publication of our work identifying human LBR and LAP2 as key heterochromatin tethers at the nuclear envelope.

Their loss massively changes 3D chromatin organization, and causes defects in epigenetic maintenance and cell fate determination.

doi.org/10.1038/s415...

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

☕ @kutaylab.bsky.social & co identify #lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether #heterochromatin to the envelope. Deletion of these proteins causes changes in 3D #genome organization, gene expression and cell fate determination.
bit.ly/4aPkNBc

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

We are delighted by the publication of our work identifying human LBR and LAP2 as key heterochromatin tethers at the nuclear envelope.

Their loss massively changes 3D chromatin organization, and causes defects in epigenetic maintenance and cell fate determination.

doi.org/10.1038/s415...

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis DYT1 early-onset dystonia is a severe, incurable disorder of the central nervous system caused by mutations in the gene encoding Torsin1A (Tor1A, DYT1). Torsins are ER-resident AAA+-ATPases implicated...

We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025...

Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!

Publication by the Kutay lab with first author Claudia Gafko "Establishment of an imaging-based screening pipeline for the identification of human ribosome biogenesis inhibitors" in BMC Biol
nccr-rna-and-disease.ch/news/article...
@kutaylab.bsky.social
@ethz.ch

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis DYT1 early-onset dystonia is a severe, incurable disorder of the central nervous system caused by mutations in the gene encoding Torsin1A (Tor1A, DYT1). Torsins are ER-resident AAA+-ATPases implicated...

We are very excited that our work on Torsins, dystonia and NE membrane fusion is out on bioRxiv: doi.org/10.1101/2025...

Fantastic collaboration with Madhav Jagannathan and the labs of Gautam Dey and Stefano Vanni!