@glowsticks
Peptide engineering, supramolecular chemistry, DNA binding, caged molecules, luminescent sensors & chemistry art. "A jack of all trades is a master of none, but oftentimes better than a master of one." ORCID: 0000-0001-7500-985X http://www.chembiousc.gal
Glad people are settling on the term "pervert glasses". Bonus points if you also say it while posting a picture of Mark Zuckerberg or call them Mark Zuckerberg's pervert glasses.
I fucking hate proline so fucking much it's the worst amino acid it's so fucking stupid it's incapable of being fucking normal so it forms an ugly ass ring with itself with its own fucking nitrogen cuz it's a loser fucking amino acid I hate it so much I'd rather cut off my right tit than have to ever draw a mechanism with proline ever again
Remember that everyone you meet is fighting their own battle, sometimes with amino acids
I have a lifelong “@alum.mit” forwarding address from my postdoc days. It’s awesome and every university should adopt for their alumni.
Hey, Anyone could help me find the pdf for this publication? shm.to/4zJWLSU
DOI: 10.1016/S0031-6997(25)06847-4
I would normally just email the author asking for it, but this is kind of old... Thank you in advance for your help!
#canihazpdf #ChemSky
The absurdity of AI companies whining about intellectual property theft. www.theguardian.com/technology/2...
"Moderna's CEO announced the company will no longer invest in new Phase 3 vaccine trials for infectious diseases: 'You cannot make a return on investment if you don't have access to the U.S. market. Vaccines for Epstein-Barr virus, herpes, and shingles have been shelved.” 9:12 AM Feb 12, 2026 604.8K Views
In terms of what cures are being lost:
- Epstein-Barr virus is perhaps the major trigger for multiple sclerosis
- herpes simplex virus causes cold sores, genital herpes, infections in babies, deadly meningitis
- shingles virus causes an intensely painful disease
#CiQUS researchers have just published a JACS communication reporting an unconventional strategy to uncage drugs in live settings, based on a photoredox unmasking of aromatic C–H bonds
Congratulations to the authors on this outstanding work!
pubs.acs.org/doi/10.1021/...
#FondosEuropeos #RedeCIGUS
You’re mistaken. Ozempic (and the rest of GLP-1 peptide inhibitors) are made through solid-phase peptide synthesis. Insulin is a recombinant protein made in a totally different way.
I feel like getting the dudes who demand government issued girlfriends out of the gene pool might be one of those problems that solves itself
One thing I tell people over and over and over again is just how much luck I have had in my career... plus, you know, privilege, which is a systemic boost that makes luck more likely for some. Yes, I'm good at what I do. So are a lot of other people who have not had my luck. No shame to admit it.
As a chemist, I really, really, liked his earlier work on caged Ca2+ chelators. Really beautiful and creative stuff.
A poster that reads: you can’t spell hatred without red hat accompanied by a drawing of a red hat
Everything is awful but the creativity behind some of these handmade posters gives me a glimmer of hope in humanity.
Break Free from US Big Tech
Digital sovereignty starts with everyday choices
Switch to European file hosting services - built by companies based in the EU, EEA, and EFTA
Discover → Choose → Support Europe 🇪🇺
#DigitalSovereignty #SupportEuropeanTech
european-alternatives.eu/category/fil...
The core ideas are applicable to many successful proposal types for funding beyond NIH.
www.pnas.org/doi/10.1073/...
I'm sorry. As a technology writer, I'm supposed to be telling you that this bet will some day pay off, because one day we will have shoveled so many words into the word-guessing program that it wakes up and learns how to actually do the jobs it is failing spectacularly at today. This is a proposition akin to the idea that if we keep breeding horses to run faster and faster, one of them will give birth to a locomotive. Humans possess intelligence, and machines do not. The difference between a human and a word-guessing program isn't how many words the human knows. I'm sorry. I know that when we talk about "digital sovereignty," we're obliged to talk about how we can build more data-centres that we can fill up with money-losing chips from American silicon monopolists in the hopes of destroying as many jobs as possible while blowing through our clean energy goals and enshittifying as much of our potable water as possible.
Córy Doctorow with another verbal bullseye: pluralistic.net/2026/01/13/n...
Is that the one with Darth Vader at the Death Star restaurant?
A workflow diagram: Have great idea Finish project Start project Tell everyone The finish project is missed out.
Morning
we're not going to have the craigpost become this, or the other times we've had it "break character" and do commentary on the horrible era we are living through, every week.
in this nightmare, just try and do one silly post a week.
doesn't make it less true though
This view resonates deeply with me:
⬛ Publish fewer claims and more proof
Papers need to include fewer claims and more proof to make the scientific literature more reliable
What is driving today’s ‘claims inflation’?
1/3
Near the C-terminus in the right. It looks like AI crap.
Change my mind meme with the text “Strauss waltzes at the Vienna New Year’s Concert were basically 19th-century reggaeton”
🎉 Happy new year everyone!! 🎉
How do you people find time to read so many books!?!
I have loved Iron & Wine since his first album, and twenty years later he is still just as good (I know this is an old video, but just listen to him!)
youtu.be/z5iqugyjKas?...
At a minimum, every researcher directly or indirectly related to this trial should be barred from any research position, project, consortium or funding whatsoever in the EU @erc.europa.eu @ec.europa.eu
www.theguardian.com/society/2025...
The 'Version of Record' of our paper came out on #FluorescenceFriday
elifesciences.org/articles/105...
The field of peptide therapeutics is exploding with many new approvals in the last decade. However, the manufacturing of peptide therapeutics is lagging behind. We have been investing in novel approaches to manufacture peptides since 2016.
Never forget: Elon Musk has blood on his hands.