Transposable elements, such as retrotransposons and endogenous retroviruses, are being recognized for their important roles in genome function and impact on disease development. How can we translate our growing understanding of the 'dark genome' into therapeutics? go.nature.com/4tQ1zTn
rdcu.be/e7D2N
Meet Reinier Hernandez, assistant professor of @wiscmedphys.bsky.social @uwiscradiology.bsky.social, whose Advanced Radiotheranostics Laboratory aims to harness the power of radionuclides to tackle problems in diverse areas of biomedical research.
Development of a photostable pH biosensor based on mStayGold https://www.biorxiv.org/content/10.64898/2026.03.06.710027v1
ICYMI: New online: A proteome-wide dependency map of protein interaction motifs
Our lab is hiring a research technician! We are interested in reproduction, stem cells, and development. If you are seeking a robust 2-year career experience before the next chapter of your educational journey, this is the position for you!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n
I was on Capitol Hill today with @asbmb.bsky.social urging lawmakers to support strong federal investment in
scientific research and training. Also to support : predictable and sustained funding.
#ASBMBAdvocates #ScienceServesUsAll
Figure 1. Cryo-EM of abundant protein complexes in native membranes.
Figure 2. Cryo-EM of membrane proteins in vesicles.
Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.
Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.
I've written a review on what I think is an extremely exciting direction in cryo-EM:
Cryo-EM of endogenous membrane proteins in their native lipid bilayer
Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...
The results are finally in! 🏆💻🧬
I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵
"Brian looks for enzymes that have evolved to harness them for new, industrial uses, like the deconstruction of biomass for use in biorenewable chemicals and fuels," says Jennifer Gottwald, WARF director of licensing.
Huge congratulations, Yasu!!! Well-deserved for the outstanding program that you are running! 💪🎉
Dorothy Crowfoot Hodgkin, biochemist & a trailblazer in crystallography, she established the biomolecular structures of insulin, vitamin B12, & penicillin winning the Nobel in Chemistry in 1964 #WomensHistoryMonth #WomenInStem #WomenInScience
Paper alert from @codyz.bsky.social y.social and Yang Liu. New mechanism for chromatin remodeling by ATRX. Super cool story. Congrats to #lugerlab alumni.
www.biorxiv.org/content/10.6...
Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.
The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 !
www2.rnasociety.org
👀 At #BPS but haven’t stopped by booth 401 yet? Meet the team to discover how you can unlock the ultimate #single-molecule resolution at your benchtop, generating high-impact insights into #biomolecular interactions and dynamics. See you there! @biophysicalsoc.bsky.social #biophysics #lifescience
Job opening for Research Group Leader in Structural Studies at MRC Laboratory of Molecular Biology, focusing on macromolecular structures.
Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme?
Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues.
Apply by 16 MAR
www.nature.com/naturecareer...
Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...
Just published in @science.org with related Perspective by Françoise Jacob-Dubuisson.
Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization | Science www.science.org/doi/10.1126/...
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause
@science.org Evolution of error correction through a need for speed | Science #evolution 🧬🔬 www.science.org/doi/10.1126/...
Papers are like buses... You wait for ages, then two come along at once.
Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!
www.nature.com/articles/s41...
Our paper is now out in Nature:
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres.
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Top: A representative modeling example from Chimpanzee CPEB3 HDV-like ribozyme (PDB ID: 7QR3), with models predicted by four better-performing methods (blue cartoons) overlaid on experimental structure (gray cartoons). Left to right: DRFold2, DeepFoldRNA, AlphaFold3, RhoFold. Bottom: Structural visualization of the example from coxsackievirus B3 cloverleaf RNA (PDBID: 8DP3), showing experimental structure (left), AlphaFold3’s best prediction from 100 models (middle), and 5th model of DRfold2 (right), respectively. Structures are rainbow-colored from 5′ (blue) to 3′ (red) end.
Accurate RNA structure prediction remains a challenge, despite recent computational advances. This study presents DRFold2, a #DeepLearning framework that significantly enhances accuracy of de novo #RNAstructure prediction by increasing contact prediction precision @plosbiology.org 🧪 plos.io/4aoOQiX
Awesome seminar today by UCSF's @willowcoyote.bsky.social! He is not afraid to blaze his own trail, redefining paradigms along the way!
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
Have you applied to be a reviewer @biologyopen.bsky.social ? pays £220/manuscript journals.biologists.com/bio/pages/fa...
Congratulations!!!
The Structura logo with dates for the workshop listed. The bottom reads "Hosted by SickKids and Structura Biotechnology"
Deadline approaching to register for the @structurabio.bsky.social & @sickkidsto.bsky.social CryoSPARC workshop in Toronto!
Open to all, this is a unique opportunity to learn CryoSPARC from the experts at Structura.
April 30/May, 2026.
For more information and to register:
tinyurl.com/y42pf4wy
