Springer Medicine

Advanced Therapeutics in Parkinson’s Disease: What’s New? Review innovations in continuous infusion therapies, MR-guided focused ultrasound, deep brain stimulation, and emerging cell-based approaches that are expanding treatment options for patients with…

What's new in advanced therapeutics for #ParkinsonDisease?

Explore the innovations in continuous infusion therapies, MR-guided focused ultrasound, deep brain stimulation, and emerging cell-based approaches that are expanding treatment options/

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#NeuroSky

Management of Thyroid Eye Disease: A Comparison Between Three Recent Clinical Guidelines Managing mild TED is highly consistent across European (EUGOGO), Chinese (CMA), and American–European (ATA–ETA) guidelines, but approaches diverge for moderate-to-severe disease and for specific…

Thyroid eye disease: how do guidelines compare?

Managing mild TED is highly consistent across European, Chinese, and American–European guidelines, but approaches diverge for moderate-to-severe disease and for specific patient populations.

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#EyeSky

How does air pollution affect cardiovascular health?

Listen to our conversation with Dr. Anusha Seneviratne to find out more about the known mechanisms, epidemiological evidence, and preventive measures.

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#CardioSky #AirPollution
@anushans.bsky.social

Neoadjuvant Therapy in Cisplatin-Ineligible Muscle-Invasive Bladder Cancer: Recent Progress, Challenges, and Future Directions in the Era of TAR-200 and Enfortumab Vedotin Plus Pembrolizumab Discover the two conceptually distinct paradigms that could transform the neoadjuvant treatment of cisplatin-ineligible patients with muscle-invasive bladder cancer, and understand how they might be…

Discover the two conceptually distinct paradigms that could transform the neoadjuvant treatment of #cisplatin-ineligible patients with muscle-invasive #BladderCancer, and understand how they might be selected and sequenced.

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#OncSky

Immunosuppressants may not boost belimumab monotherapy in SLE Patients with systemic lupus erythematosus treated with belimumab monotherapy have similar disease control, flare, and treatment response rates as those given the drug in combination with…

#MedNews - Patients with #SLE treated with #belimumab monotherapy have similar disease control, flare, and treatment response rates as those given the drug in combination with immunosuppressant therapy.

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#RheumSky #Lupus

Deciphering whipple’s disease complexity The latest insights into Whipple disease, from epidemiology and pathophysiology to clinical manifestations and treatment. Explore confounding factors in diagnosis and management, and current…

Get the latest insights into #WhippleDisease, from epidemiology and pathophysiology to clinical manifestations and treatment, in this review.

Explore confounding factors in diagnosis and management, and current treatment limitations.

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#IDSky #GastroSky

Smartphone-Based Portable Slit Lamp in Anterior Segment Diseases: A Narrative Review of Clinical Assessment and Integration with Artificial Intelligence Emerging evidence shows smartphone-based portable slit-lamps – particularly when equipped with AI – can deliver accurate, low-cost screening with automated detection and grading across key anterior...

Emerging evidence shows smartphone-based portable slit-lamps – particularly when equipped with #AI – can deliver accurate, low-cost screening with automated detection and grading across key anterior segment disorders.

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#EyeMed

Hyperoxaemia in acute brain injured patients: too much of a good thing? Accumulating data suggest excessive oxygen use in brain-injured ICU patients contributes to secondary brain injury. The optimal oxygenation approach remains uncertain, but clinicians must balance the…

Data suggests excessive oxygen use in brain-injured ICU patients contributes to secondary #BrainInjury.

The optimal oxygenation approach remains uncertain, but clinicians must balance the competing risks of #hypoxemia and #hyperoxemia.

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#NeuroSky #ICUMed

Methotrexate-associated gynecomastia A reminder to consider methotrexate as a potential cause of gynecomastia, even with long-term low-dose therapy and in euhormonal states. Conservative measures such as dose reduction or folate…

#MedCase - A reminder to consider #methotrexate as a potential cause of #gynecomastia, even with long-term low-dose therapy and in euhormonal states.

Conservative measures such as dose reduction or folate supplementation may lead to symptom reversal.

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#RheumSky

Early ileocecal resection offers long-term remission for some Crohn’s disease patients Ten-year results of the LIR!C trial suggest that ileocecal resection offers a higher rate of long-term, therapy-free remission than infliximab for patients with uncomplicated ileocecal Crohn’s disease.

#MedNews - Ten-year results of the LIR!C trial suggest that ileocecal resection offers a higher rate of long-term, therapy-free remission than #infliximab for patients with uncomplicated ileocecal #CrohnsDisease.

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#GastroSky

Lutembacher’s syndrome presenting in the third trimester: a multidisciplinary challenge in a low-resource setting Management of Lutembacher’s syndrome during pregnancy requires a coordinated, multidisciplinary approach to mitigate the high risk maternal and fetal complications. This case highlights the…

#MedCase - Management of Lutembacher’s syndrome during pregnancy requires a coordinated, multidisciplinary approach to mitigate high risk complications.

This case highlights the challenges of its management in a low-resource setting.

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#CardioSky

No 90-day survival benefit with albumin in septic shock patients Albumin replacement in septic shock does not improve 90-day survival compared with standard fluid resuscitation, the ARISS trial shows.

#MedNews - Albumin replacement in #SepticShock does not improve 90-day survival compared with standard fluid resuscitation, the ARISS trial shows.

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#IDMed #ICUMed

Rapid fluid resolution may signal reduced faricimab injection frequency in nAMD Early retinal drying in people with neovascular age-related macular degeneration receiving faricimab treatment may signal improved disease control that allows subsequent injection intervals to be…

#MedNews - Early retinal drying in people with neovascular age-related macular degeneration receiving #faricimab treatment may signal improved disease control that allows subsequent injection intervals to be extended.

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#EyeSky #nAMD

Very late-onset Krabbe disease with concomitant dementia: case description and a critical review of the literature KD usually occurs in infancy, but adult-onset cases are increasingly described. KD should always be considered in very late-onset spastic paraplegia, as in this 66-year-old with concomitant cognitive…

#MedCase - #KrabbeDisease usually occurs in infancy, but adult-onset cases are increasingly described.

KD should always be considered in very late-onset spastic paraplegia, as in this 66-year-old with concomitant cognitive decline.

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#NeuroSky

Call to strengthen sudden cardiac death screening strategies in young people A single cardiac screening in just over 1 million young people in the general population has identified conditions associated with sudden cardiac death in 0.3% that led to risk-modifying treatment in…

#MedNews - A single cardiac screening in just over 1 million young people in the general population has identified conditions associated with sudden cardiac death in 0.3% that led to risk-modifying treatment in 41.1% of cases.

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#CardioSky #SCD

Tenecteplase improves outcomes in stroke due to basilar artery occlusion Intravenous tenecteplase thrombolysis within 24 hours of stroke onset improves functional outcomes versus standard medical treatment in patients with basilar artery occlusion.

#MedNews - Intravenous #tenecteplase thrombolysis within 24 hours of #stroke onset improves functional outcomes versus standard medical treatment in patients with basilar artery occlusion.

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#NeuroSky

Etoposide dosing challenges in a testicular cancer patient with hepatic impairment and drug-drug interactions–a case report This case of a testicular cancer patient with cystic fibrosis and liver cirrhosis shows that monitoring of etoposide concentrations can be beneficial in complex scenarios involving organ dysfunction…

#MedCase - This case of a #TesticularCancer patient with #CysticFibrosis and #LiverCirrhosis shows that monitoring of #etoposide concentrations can be beneficial in complex scenarios involving organ dysfunction and/or potential drug–drug interactions.

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#OncSky

Prebiotics, Probiotics, and Postbiotics in Modulating Gut Microbiota: Emerging Therapeutic Approaches for Metabolic Syndrome Biotics have the potential to improve metabolic syndrome by reducing weight gain, insulin resistance, dyslipidemia, inflammation, and improving glycemic control and gut barrier function.

Biotics have the potential to improve #MetabolicSyndrome by reducing weight gain, insulin resistance, #dyslipidemia, inflammation, and improving glycemic control and gut barrier function.

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#EndoSky #GutMicrobiome

Human infections caused by pathogenic Burkholderia: current clinical challenges and future perspectives Burkholderia species present substantial diagnostic and therapeutic challenges due to their virulence and intrinsic antimicrobial resistance. This review synthesizes current knowledge on the…

#Burkholderia species present substantial diagnostic and therapeutic challenges due to their virulence and intrinsic antimicrobial resistance.

This review synthesizes current knowledge on the clinically significant pathogens.

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#IDMed #Melioidosis

ETVAX protects against infant enterotoxigenic E. coli diarrhea An oral whole-cell vaccine against enterotoxigenic Escherichia coli is immunogenic and well tolerated in infants, and should advance to a phase 3 trial.

#MedNews - An oral whole-cell vaccine against enterotoxigenic #EColi is immunogenic and well tolerated in infants, and should advance to a phase 3 trial.

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#IDMed #GastroSky

SGLT2 inhibitors improve outcomes over DPP4 inhibitors in type 2 diabetes with liver cirrhosis SGLT2 inhibitors are linked to lower kidney, cardiovascular, and hepatic risks than DPP-4 inhibitors in patients with type 2 diabetes and liver cirrhosis.

#MedNews - #SGLT2 inhibitors are linked to lower kidney, cardiovascular, and hepatic risks than #DPP4 inhibitors in patients with type 2 diabetes and liver cirrhosis.

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#T2D

The evolving concept from Cardiovascular-kidney-metabolic syndrome to metabolic associated liver-cardiovascular-kidney syndrome: insights from endocrinology Given the association of MASLD with cardiovascular, renal, and endocrine metabolic disorders, should cardiovascular-kidney-metabolic syndrome evolve to metabolic-associated…

Given the association of #MASLD with cardiovascular, renal, and endocrine metabolic disorders, should cardiovascular-kidney-metabolic syndrome evolve to metabolic-associated liver-cardiovascular-kidney syndrome?

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#EndoSky #MedSky

Varicose veins and venous thromboembolism in inflammatory rheumatic diseases: vascular complications and rehabilitation approaches Varicose veins and venous thromboembolism can occur in the context of chronic inflammation in inflammatory rheumatic diseases. Find out more about the key risk factors and prevention and…

#VaricoseVeins and venous thromboembolism can occur in the context of chronic inflammation in inflammatory rheumatic diseases.

Find out more about the key risk factors and prevention and rehabilitation strategies.

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#RheumSky

Breast Cancer Brain Metastases: Current Understanding and Future Directions Explore the current knowledge of breast cancer brain metastases, from metastatic mechanisms to tumor microenvironment interactions, and learn how this understanding is driving diagnostic and…

Explore the current knowledge of #BreastCancer brain metastases, from metastatic mechanisms to tumor microenvironment interactions, and learn how this understanding is driving diagnostic and therapeutic developments.

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#OncSky

Hyponatraemia in heart failure: a mechanistic approach to contemporary management Hyponatremia in heart failure reflects specific pathophysiological mechanisms that demand targeted intervention alongside standard decongestion strategies. This review outlines a phenotype-informed…

#Hyponatremia in HF reflects specific pathophysiological mechanisms that demand targeted intervention alongside standard decongestion strategies.

This review outlines a phenotype-informed management framework to support effective care.

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#CardioSky #HeartFailure

Varicella zoster virus acute retinal necrosis miming papillitis: a case report Slight pain related to eye movement and decreased visual acuity indicated papillitis. But rapid vision loss revealed an unusual initial finding of optic nerve involvement preceding retinal necrosis –…

#MedCase - Slight pain related to eye movement and decreased VA indicated #papillitis.

Rapid vision loss revealed an unusual initial finding of optic nerve involvement preceding retinal necrosis.

But what was the cause?

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#EyeSky #IDSky

Overlapping autoimmunity and demyelination syndromes associated with TNF inhibitor therapy A unique case of both MOGAD and emergent lupus developing after anti-TNF treatment in a patient with ankylosing spondylitis, highlighting the need for increased clinical awareness of the…

#MedCase - A unique case of both #MOGAD and emergent #lupus developing after anti-TNF treatment in a patient with ankylosing #spondylitis, highlighting the need for increased clinical awareness of the immunological consequences of TNF blockade.

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#RheumSky

Global hyperuricemia rate doubles in 2 decades The estimated number of people living with hyperuricemia has more than doubled in the past 20 years, likely due to both population growth and aging, and rising prevalence.

#MedNews - The estimated number of people living with #hyperuricemia has more than doubled in the past 20 years, likely due to both population growth and aging, and rising prevalence.

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#RheumSky

Artificial Intelligence-Based Medical Devices for Diabetic Retinopathy Screening in the European Union CE-certified AI systems are a rapidly evolving component of screening programs in parts of Europe, with high diagnostic accuracy for referable DR, but heterogeneous evidence for detecting…

Diabetic #retinopathy screening: how reliable is #AI?

CE-certified AI systems are a rapidly evolving component of some screening programs, with high diagnostic accuracy for referable DR, but mixed evidence for detecting sight-threatening DR.

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#EyeSky

Cholesterol Treatment Trialists' Collaboration calls for revision of ‘misleading’ statin labels Most potential undesirable effects listed in statin product labels are not specifically caused by statin treatment.

#MedNews - Most potential undesirable effects listed in #statin product labels are not specifically caused by statin treatment.

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#CardioSky #Cholesterol