Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

Aluminium - a study in structure. Enjoy this month's scientific picture from Stephanie Wendt (Technical Services).

Congrats to Milena Roth on receiving the Master’s Prize of the German Society for Biochemistry and Molecular Biology! 🎉 Her outstanding thesis in @agatawitkowska.bsky.social group at FMP uncovered new insights into neuronal protein–membrane interactions.

Scientific picture of the month by Pia Venneker (Lipstein lab): An elegant mix of stardust, nervous breakdown, and fluorescent spaghetti – hippocampal neurons with astrocytes, glowing nuclei, neuron markers and dendrites. 💥

Exciting discovery! AG Lange and the FMP Chemical Biology Section at FMP identified selective inhibitors of intramembrane rhomboid proteases and revealed their modes of action.Full paper: onlinelibrary.wiley.com/doi/10.1002/...

Picture: Created in BioRender. Bohg, C. (2026) biorender.com/vi9hi4f

Cold Snow, warm sun and bright ideas: The first scientific picture of the New Year, captured by Franziska Ringleb (FMP Directorate).

New in PNAS: Tight junctions tune kidney Ca2+ flow. Using high‑res imaging, CLDN14 swaps in for CLDN16, breaks the CLDN16/19 pore, and lowers Ca2+ reabsorption.

Read: www.pnas.org/doi/10.1073/...

Bettina Winckler (UVA) at the FMP

A fascinating seminar today with Prof. Bettina Winckler (UVA) at @fmp-berlin.de! She shared incredible insights into endosome trafficking in neurons. Thanks to ECN Berlin for funding our "Molecular Mechanisms of Neuronal Connectivity" series. @neurocure.bsky.social @einsteinberlin.bsky.social

May the (icy) force be with you ⚔️: This month's scientific picture comes from Abhirup Majumdar (Fiedler lab). This ice sculpture was formed at the base of a flask during an exothermic reaction at low temperatures 🧊. Great contribution!

Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function - Nature Genetics Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and...

New study by @noalipstein.bsky.social and Nils Brose, @mpi-nat.bsky.social links UNC13A gene variants to a new developmental disorder — offering insights into ALS and potential therapies. 👏

Read the full paper: www.nature.com/articles/s41...

Congrats to Sigrid Milles, junior group leader at @fmp-berlin.de on receiving a Boehringer Ingelheim Stiftung Exploration Grant! 🎉 Her team studies how flexible, intrinsically disordered proteins form condensates to control clathrin-mediated endocytosis — combining NMR, smFRET & live-cell work. 🧫🫧

WSR088 LNDW 2025: Depression & intrinsisch unstrukturierte Proteine Diese Episode wurde bei der LNDW 2025 aufgezeichnet. Darin sprechen Bernd Rupp und Ralf Schülein über Depressionen sowie Therapien mit Antidepressiva. Anschließend erläutert Sigrid Milles die Rolle in...

Neue Episode im Wirkstoffradio! WSR088 LNDW 2025: Depression & intrinsisch unstrukturierte Proteine mit Gästen aus dem @fmp-berlin.de
www.wirkstoffradio.de/2025/10/12/w...
#LNDW #Wissenschaftspodcast #Medizin #Podcast #Leibniz #Berlin #Depression #IDP

Our scientific picture of the month sets a spooky vibe 👻🎃
Thanks to the @broichhagenj.bsky.social lab for providing us with Chem o'lanterns

Another award for Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Professor at Freie Universität Berlin: The Deutsche Forschungsgemeinschaft (DFG) -… ... Another award for Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Professor at Freie Universität Berlin: The Deutsche Forschungsgemeinschaft (DFG) - G...

Congratulations to @volkerhaucke-lab.bsky.social for receiving the prestigious Reinhart Koselleck Grant by the @dfg.de (German Research Foundation) once again! 🎉

www.linkedin.com/feed/update/...

Congrats to Volker Haucke, Director at the Leibniz-FMP on being awarded the Ernst Schering Prize 2025 for his pioneering work on the function of signaling lipids that control how cells respond to hormones, nutrients and messengers.

Energy-transfer photoproximity labelling in live cells using an organic cofactor - Nature Chemistry Current photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofa...

🔥After years of hard work, it's finally out in @natchem.nature.com🔥 The Hackenberger group @fmp-berlin.de developed #🎯DarT-labeling, a #photocatalyticproximitylabeling method using deazaflavin - a ✅ biocompatible ✅ easily synthesized ✅ chemically benign #photocatalyst

www.nature.com/articles/s41...

Daniel Roderer and his group revealed the first high-res structure of Fap2 from Fusobacterium nucleatum (cryo-EM/ET). Fap2 binds immune cells (TIGIT) and colorectal cancer cells (Gal-GalNAc), showing how Fusobacteria colonize tumors and escape the immune system.
www.nature.com/articles/s41...

Nucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation - Nature Chemistry Our understanding of how post-translational modification—protein phosphorylation—impacts the complexity of eukaryotic signalling pathways is continuously expanding. Now, protein oligophosphorylation h...

Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation.

www.nature.com/articles/s41...

Promiscuous and multivalent interactions between Eps15 and partner protein Dab2 generate a complex interaction network - Nature Communications Eps15, a protein involved in endocytosis initiation, uses small folded EH domains to bind disordered partner proteins and its own disordered tail, thus forming a dynamic network via phase separation t...

I am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS).

www.nature.com/articles/s41...

Great work by @broichhagenj.bsky.social at Leibniz-FMP, David Hodson at @rdm.ox.ac.uk and the whole team!

⏰Join us for the NMR Symposium, Nov 26–27, 2025, celebrating our new 1.2 GHz NMR spectrometer. To present a poster, send your abstract to NMR2025@fmp-berlin.de. Registrations are open until September 15th!

Great cover art by @barthvanrossum.bsky.social for @jacs.acspublications.org: Influenza lifecycle showing M2’s roles, from activation in the low-pH endosome to viral uncoating, RNA release, and budding of new particles. View the article from the Lange lab here: pubs.acs.org/doi/10.1021/...

Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites.

PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) at Leibniz-Forschungsinstitut für Molekulare Pharmakologie We're looking for: PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) (Part Time) • Berlin, Deutschland

PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET, Dr. Sigrid Milles, The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmp-berlin.de Berlin, Germany leibniz-fmp.softgarden.io/job/58144047... #NMRjobs #NMRchat #NMR 🧲

Our scientific image of the month July comes from Kati Fischermanns, @broichhagenj.bsky.social lab and is titled: "96 wells celebrate diversity" 🌈 It was created by scaling up tunable photocontrol over cells.

With his exceptional work, Prof. Dr. Volker Haucke @volkerhaucke-lab.bsky.social has made it onto the #FallingWallsFoundation shortlist for the #ScienceBreakthrough of the Year 2025 in the #LifeSciences category. Congratulations!

The #LongNightoftheSciences at @fmp-berlin.de was a great success: Many visitors took a look behind the scenes during the lab tours and were inspired by research.

Thanks to everyone who came and see you around next year!

Kampf dem Kunststoff!
In der Forschung fallen Unmengen #Plastikmüll an. Lässt sich das ändern?
www.leibniz-magazin.de/alle-artikel...
#LeibnizMagazin #Müll #Nachhaltigkeit #Forschung @fmp-berlin.de

New in @jacs.acspublications.org:

New insights into the flu virus: The Lange lab used proton-detected solid-state NMR combined with the Sun lab's expertise in QM/MM+MD simulations to reveal how pH changes drive conformational shifts in the influenza A M2 channel.

pubs.acs.org/doi/10.1021/...

Wonderful to present my work leading a large European consortium around @fmp-berlin.de and @eu-openscreen.bsky.social at #ELMI2025. We produce large-scale #open-source high quality Cell Painting data for drug discovery 💊. First dataset published: doi.org/10.1016/j.is...

Stay tuned for more!

Get ready for this upcoming event, a lecture series on Allostery in Drug… | Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Get ready for this upcoming event, a lecture series on Allostery in Drug Discovery (ALLODD) - hosted by Prof. Dr. Marc Nazaré from Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Dr....

Get ready for this upcoming event:

Lecture series on Allostery in Drug Discovery 💊

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