Aurélien Doucet

We were all very sad to learn the death of Pierre Capy. Pierre was a professor at University Paris Saclay, in the 1990s, he started a group working on the evolutionary genomics of transposable elements; this group is still very active today. He was a great teacher, mentor, and colleague.

Pierre Capy était un généticien, un drosophiliste, un acteur majeur dans l'essor de la génétique des éléments transposables en France.
Très impliqué dans l'administration de la vie scientifique, il a aussi été directeur du laboratoire LEGS (actuel @EGCE), et un des fondateurs en 2016 de @IDEEV.

Bravo à Gaël Cristofari lauréat du Prix Michel Delalande
Ses travaux à l’IRCAN (Université Côte d’Azur, @insermpacacorse.bsky.social , @cnrscotedazur.bsky.social ) sur la « face cachée du génome » et les rétrotransposons ouvrent de nouvelles pistes pour la pharmacologie et la lutte contre le cancer.

We are recruting an assistant engineer for 18 months at LBBE (Lyon, France) in molecular biology of Drosophila. The project is to study the interactions between response to viral infections and control of transposable elements.
emploi.cnrs.fr/Offres/CDD/U...

TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.

📖 Les filles sont parfaites pour les sciences, un ouvrage qui met en lumière des chercheuses, ingénieures et techniciennes.
👩‍🔬 48 femmes, 48 parcours, une même passion : la science.
Très fière de faire partie de cette belle aventure 💛
📘 En librairie le 15/10
👉 www.editionsmkf.com/femmes-et-sc...
1/2

Pathogen Immunity and Signalling Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…

🔥 Mark the date! 🗓️

Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.

Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.

Submit your abstract.

Join us on 8 – 11 June 2026.

meetings.embo.org/event/26-pat...

Join IGMM ! 🧬
Postdoctoral Fellow in Oncogenesis.
Apply now 👉 emploi.cnrs.fr/Offres/CDD/U...

#Postdoc #OncologyResearch #ScienceJobs #IGMM #CNRS

Transposable elements are vectors of recurrent transgenerational epigenetic inheritance DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...

Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...

Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky

Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis Retrotransposons are mobile repetitive elements that constitute around 43% of the human genome. Normally silenced through epigenetic mechanisms, retrotransposons can become reactivated in response to ...

Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

Aedes albopictus (asian tiger mosquito)

🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics

Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes Group II Introns (G2Is) are large self-splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2,...

Have you ever wanted to design large and complex ribozymes from scratch? I know I have!

We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!

#intron #RNAsky #SynBio 🧬🧵(1/n)

Congrats Paula !!!

🌊 Tout le mois de juin, dans le cadre de l'Année de la Mer et en marge de l' #UNOC3, retrouvez la très belle exposition du @cnrs.fr "L'océan si fort et si fragile" sur la Promenade de l'Octroi à Villefranche-sur-Mer !

Les experts décryptent ce monde bleu, clé de l’équilibre de notre planète 🌎

Ce 22 mai, le campus Valrose d’Université Côte d’Azur a accueilli plus de 500 élèves issus de 25 classes de collèges et lycées pour la grande restitution de fin d’année des projets scolaires "Science et Société".
Une journée placée sous le signe de la curiosité scientifique et de la créativité !

Our paper is now published in its final form: rdcu.be/elV6u @biomedcentral.bsky.social @salehlabparis.bsky.social @merklinglab.bsky.social @pasteur.fr

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

💥🥳 At long last, our latest paper is out!

Gag proteins of endogenous retroviruses are required for zebrafish development

www.pnas.org/doi/10.1073/...

Led heroically by Sylvia Chang & @jonowells.bsky.social

A study which has changed the way I think of #transposons! No less! 🧵 1/n

Celebrating DNA Day with transposable elements Each year on DNA Day, we celebrate the DNA double helix structure and the Human Genome Project's completion. Here we dive into a fascinating genomic component: transposable elements. Once seen as mere...

go.nature.com/3S27sLp

Interested in the analysis on Transposable elements? 🧬
Have a look at our course with @valentinapeona.bsky.social & @ritarebollo.bsky.social

We'll cover everything from TE biology to de novo library construction, quantification, & transcriptomic analysis.

www.physalia-courses.org/courses-work...

Hoping for a gig on the Cote d'Azur in 2026 !!! Many ladies of a certain age are waiting for you !!!

Fantastic talk by @aktast.bsky.social unraveling how RNA binding proteins tame the TE transcriptome, control their exonization and allow for the peaceful co-existence of TE and host genes.
LOVE IT. #TECSHA

Great talk by @emiliebrasset.bsky.social at #TECSHA on the regulation of piRNA production in germline vs somatic compartments of Drosophila ovary. Sophisticated mechanisms have evolved to control different sets of TEs, to the benefit (I think) of both host and TEs.

Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated

Un scientifique utilise la chimie pour créer des œuvres d'art visuelles époustouflantes. En combinant différents éléments et réactions chimiques, il produit des images fascinantes dans une goutte d'eau 💧!

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide Nature Structural & Molecular Biology - Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA...

Our study with Anjana Rao's lab was just published at NSMB 🥳 Shows how OGT prevents TET proteins from activating retrotransposons, particularly those in heterochromatin. Paper has 6-base and ONT sequencing data from OGT iKO mESCs, and also interesting OGT inhibitor data 👀.

rdcu.be/efuho

Le mot du mois #Recherche 📚
Les travaux sur les gênes sauteurs offrent de nouvelles perspectives sur l'évolution et la génétique humaine, avec des applications potentielles pour le diagnostic et le traitement des cancers.
swll.to/genessauteurs

@insermpacacorse.bsky.social

Hi! Here is a PhD opportunity at Montpellier, IGH institute with Séverine Chambeyron to study endogenous retroviruses ! #TEsky #PhD

DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2

Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...