Nature Biomedical Engineering

Author Correction: Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation

An ophthalmic video foundation model for surgical recognition and navigation with wet-lab porcine eye validation Nature Biomedical Engineering, Published online: 03 March 2026; doi:10.1038/s41551-026-01622-wThe ophthalmic video foundation model learns the spatiotemporal motion features of ophthalmic procedures, improving surgical performance in cataract surgeries on wet-lab porcine eyes in real time.

An ophthalmic video foundation model for surgical recognition and navigation with wet-lab porcine eye validation

Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification Nature Biomedical Engineering, Published online: 03 March 2026; doi:10.1038/s41551-026-01628-4High-throughput and low-input quantitative citrullinome analysis integrated with deep learning reveals association between citrullinome landscape and rheumatoid arthritis severity, as well as rheumatoid arthritis-sera reactivity of identified citrullinated peptides.

Low-input deep learning platform for citrullinated peptide identification, autoantigen discovery and rheumatoid arthritis treatment stratification

Uncovering evolutionarily remote and highly potent antimicrobial peptides with protein language models Nature Biomedical Engineering, Published online: 03 March 2026; doi:10.1038/s41551-026-01630-wA protein-language-based model enables improved discovery of evolutionarily distant antimicrobial peptides (AMPs). High-confidence AMPs showed strong antibacterial activity, with the most potent demonstrating efficacy in a mouse model of E. coli infection.

Uncovering evolutionarily remote and highly potent antimicrobial peptides with protein language models

Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches Nature Biomedical Engineering, Published online: 02 March 2026; doi:10.1038/s41551-026-01617-7A strategy harnessing tissue-resident memory T cells to concentrate circulating immune cells enables non-invasive sampling of antigen-specific lymphocytes, providing a window into local and systemic immune responses in mice and humans.

Leveraging tissue-resident memory T cells for non-invasive immune monitoring via microneedle skin patches

MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis Nature Biomedical Engineering, Published online: 02 March 2026; doi:10.1038/s41551-026-01613-xChimaeric antigen receptor macrophages including the MyD88 activation domain target mesothelin for treatment of lung cancer brain metastases.

MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis

Confounding factors and biases abound when predicting molecular biomarkers from histological images

A course to help bring medical innovations from the bench to the bedside. www.nature.com/articles/s41...

Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration Nature Biomedical Engineering, Published online: 24 February 2026; doi:10.1038/s41551-026-01621-xA genetically engineered pig model carrying the human huntingtin mutation with an expanded cytosine–adenine–guanine repeat reveals microglia-driven recruitment of T cells that accelerates striatal neurodegeneration in Huntington’s disease.

Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration

Where the nanocarriers go Nature Biomedical Engineering, Published online: 20 February 2026; doi:10.1038/s41551-026-01623-9Where the nanocarriers go

Where the nanocarriers go

Decoding the DNA repair toolkit of the bowhead whale

The presubmission enquiry

Excited to share the February issue! In addition to great research content, we also have an editorial that clarifies how we think about the Presubmission Enquiry at nBME. www.nature.com/natbiomedeng...

Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology Nature Biomedical Engineering, Published online: 18 February 2026; doi:10.1038/s41551-026-01620-yA 3D soft electronic mesh allows high-resolution electrical recording and stimulation across the full surface of neural organoids, enabling long-term studies, drug testing and optogenetic control without compromising their viability owing to its porous design.

Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology

Rapid quantification of both fungal abundance and drug resistance via reaction kinetics Nature Biomedical Engineering, Published online: 13 February 2026; doi:10.1038/s41551-026-01619-5A digital CRISPR-based platform that combines reaction kinetics measurement with machine learning enables accurate quantification of pathogenic fungi and their drug-resistant mutants.

Rapid quantification of both fungal abundance and drug resistance via reaction kinetics

Generalist foundation models from a multimodal dataset for 3D computed tomography Nature Biomedical Engineering, Published online: 12 February 2026; doi:10.1038/s41551-025-01599-yThe CT-RATE dataset pairs 3D chest computed tomography volumes with radiology reports to train a foundation model for medical imaging.

Generalist foundation models from a multimodal dataset for 3D computed tomography

Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours Nature Biomedical Engineering, Published online: 11 February 2026; doi:10.1038/s41551-025-01610-6Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-derived organotypic tumour spheroids.

Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours

Injury and therapy in a human spinal cord organoid Nature Biomedical Engineering, Published online: 11 February 2026; doi:10.1038/s41551-025-01606-2A human spinal cord organoid model can replicate two different types of spinal cord injury and can be used as an in vitro system to evaluate therapeutics and inflammatory reactions to treatments.

Injury and therapy in a human spinal cord organoid

X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect Nature Biomedical Engineering, Published online: 09 February 2026; doi:10.1038/s41551-026-01612-yA platinum(II) azido complex (complex 1) that releases platinonitrene upon X-ray exposure induces DNA damage and enhances immune checkpoint blockade outcomes via the abscopal effect.

X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect

Learning neuroimaging models from health system-scale data Nature Biomedical Engineering, Published online: 06 February 2026; doi:10.1038/s41551-025-01608-0Prima is an AI foundation model for neuroimaging based on clinical magnetic resonance imaging that offers accurate and explainable diagnostics, worklist priority for radiologists and clinical referral recommendations with equitable performance on diverse groups.

Learning neuroimaging models from health system-scale data

Leveraging multi-modal foundation models for analysing spatial multi-omic and histopathology data

A programmable bioresorbable electrochemical microneedle sensor array for perioperative monitoring of organ health Nature Biomedical Engineering, Published online: 03 February 2026; doi:10.1038/s41551-025-01609-zA bioresorbable microneedle sensor array provides continuous, wireless and multimodal monitoring of organ metabolism, oxygenation and electrophysiology for up to 7 days in postoperative kidney ischaemia and gut disorders.

A programmable bioresorbable electrochemical microneedle sensor array for perioperative monitoring of organ health

High-efficiency TadA cytosine base editors for precise modelling of human disease variants Nature Biomedical Engineering, Published online: 28 January 2026; doi:10.1038/s41551-025-01607-1A suite of TadA-derived cytosine base editors was optimized to improve efficiency, reduce sequence bias, expand PAM compatibility and minimize artefacts, enabling precise genetic interrogation of variants of uncertain significance (VUS) in zebrafish.

High-efficiency TadA cytosine base editors for precise modelling of human disease variants

Automated disc device for multiplexed extracellular vesicle isolation and labelling from liquid biopsies in cancer diagnostics Nature Biomedical Engineering, Published online: 28 January 2026; doi:10.1038/s41551-025-01601-7A disc device integrating chromatography, centripetal liquid transfer and bead-based vesicle capture enables extracellular vesicle isolation and labelling, achieving high accuracy in cancer detection and tumour classification.

Automated disc device for multiplexed extracellular vesicle isolation and labelling from liquid biopsies in cancer diagnostics

AI learns across species to address human clinical imaging data sparsity Nature Biomedical Engineering, Published online: 26 January 2026; doi:10.1038/s41551-025-01586-3Limited human data, needed to train artificial intelligence (AI) models, has constrained the development of hyperspectral imaging (HSI) for surgical applications. We developed xeno-learning, an AI method that harnesses shared biological responses found across species, allowing experimental data from animals to be used in training AI models for HSI applications in humans.

AI learns across species to address human clinical imaging data sparsity

A filamentary soft robotic probe for multimodal in utero monitoring of fetal health Nature Biomedical Engineering, Published online: 26 January 2026; doi:10.1038/s41551-025-01605-3A soft robotic probe enables continuous in utero monitoring of fetal physiological parameters, including heart rate, blood oxygen saturation, temperature and electrocardiogram data, during open or fetoscopic surgery to provide real-time information on fetal condition and distress.

A filamentary soft robotic probe for multimodal in utero monitoring of fetal health

Xeno-learning: knowledge transfer across species in deep learning-based spectral image analysis Nature Biomedical Engineering, Published online: 26 January 2026; doi:10.1038/s41551-025-01585-4Xeno-learning uses preclinical data from one species to boost the performance of neural networks applied to another species when exploring physiological responses.

Xeno-learning: knowledge transfer across species in deep learning-based spectral image analysis

Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia Nature Biomedical Engineering, Published online: 23 January 2026; doi:10.1038/s41551-025-01553-yIn vitro models using tissue-specific progenitors recapitulate the lumen with gland-like structures and functional characteristics of the human stomach epithelium in a patient-specific disease model.

Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia

A droplet solution for wrapping thin bioelectronics onto complex 3D surfaces

The AI sycophant