Gutmann Lab

Diagram depicting brain tumors as nested ecosystems. Four concentric bowls represent cellular, tissue, body, and environmental levels. A second panel lists three features of nested ecosystems: diversity with spatial and temporal variation, intersectional communication within and between levels, and dynamic adaptation to external influences.

In their Perspective, Lori Forster and @gutmannlab.bsky.social apply the nested ecosystems concept to #glioma, clarify how diverse risk factors shape CNS oncobiology, and highlight new opportunities for targeted disease‑mitigation strategies.

Read: doi.org/10.1242/dmm....

We kicked off the month with a double birthday celebration! 🎉 Lori and Chloe were treated to a homemade vegan, gluten-free cake on their request (about 95% chocolate 😉). Taking time to celebrate together the good moments matters now more than ever.

Happy Hanukkah from the Gutmann lab!! 🕎 We are celebrating the 3rd day/4rd night with some delicious sufganiyot. May the lights of Hanukkah bring everyone warmth and joy in this special season.

Happy Hanukkah from the Gutmann lab!! 🕎 We are celebrating the 3rd day/4rd night with some delicious sufganiyot. May the lights of Hanukkah bring everyone warmth and joy in this season.

We’re grateful to Penny’s Flight Foundation and Kate Doerge for featuring our lab's research as part of their mission to raise awareness and critical funds to #ENDNF. This clip is just a glimpse! Go watch the full video and learn more about their amazing work on the Penny’s Flight YouTube channel.

2025 - Head and Heart honoree, Dr. David Gutmann, and Strength and Honor honoree, Harper Grace YouTube video by NFX Detroit

Join us in celebrating Dr. Gutmann as the NFX 2025 Strength & Honor honoree for his dedication to NF research and mentorship! We also recognize Harper Grace Durham, the Head & Heart honoree, whose strength and advocacy inspire the entire NF community.
Watch their shared story in the video below:

Celebrations are in full swing in the Gutmann Lab! 🎉 Yesterday’s Labsgiving and white elephant were a great way to appreciate the wonderful people who make this science family special. Wishing everyone a happy holiday season! 🎁❄️

Wishing you a boo-tiful Halloween from the lab! 🧪🎃 May your experiments work and your candy be plentiful. 👻

Last Friday,we welcomed our friends from Forward Strides 4NF,an amazing family-founded charity that brings awareness and support to the NF center with their fundraising opportunities,like the fun annual family walk you shouldn't miss! We are grateful for their endorsement and opportunity to connect💙

The FDA approved a new cancer drug by SpringWorks Therapeutics— MEK inhibitor mirdametinib (brand name Gomekli) for adult & pediatric patients (> age 2) w/ neurofibromatosis type 1-associated plexiform neurofibromas (NF1-PN) not amenable to complete resection www.cancernetwork.com/view/fda-app...

Head-to-head preclinical treatment design prioritizes promising therapies for neurofibromatosis type 1 optic glioma clinical translation AbstractBackground. Authenticated preclinical brain tumor models provide unprecedented opportunities to evaluate next-generation treatments. However, some

Excited to share our latest work in Neuro-Oncology Advances! 🥳 After comparing several potential therapies, we identified lamotrigine as a promising therapy for NF1 optic glioma, showing both tumor reduction and vision protection. Check out the work of our great team!

Aberrant coupling of glutamate and tyrosine kinase receptors enables neuronal control of brain-tumor growth Anastasaki and colleagues establish a previously unknown glutamate growth dependency in pediatric low-grade brain tumors (gliomas). Glioma cells hijack normal neuron-glial molecular circuits present d...

Exciting news! Our new paper is out in Neuron! We discovered how neurons drive brain tumor growth through aberrant glutamate–tyrosine kinase signaling, uncovering novel mechanisms that shape tumor progression. Grateful to our team & collaborators for making this breakthrough possible! 🧠✨

Pan-cancer single cell transcriptomic clustering reveals heterogeneous CD8+ exhausted T cell populations with different immune checkpoint inhibitor responses In most cancers, T lymphocytes comprise an essential cellular component of the non-neoplastic microenvironment, where they have the capacity to both suppress and support tumor growth. One specializ...

We are so proud of Rasha and Rui's new paper! Their single cell reveals hidden diversity in CD8+ exhausted T cells across cancers, shedding light on why patients respond differently to immunotherapy and bringing us closer to more effective therapies. Don’t miss this exciting advance from our team!

We were thrilled to welcome Girl Scout Troop 222 to the lab this week! They explored science hands-on and got a glimpse of the work we do. Grateful for their curios minds and amazing energy—let’s keep inspiring the next generation of scientists! 🔬💫 #GirlsInSTEM #Troop222

This past weekend we celebrated the 3rd Annual NF Family Day - a special time to honor our patients and families, build community, and have fun! From shaved ice and giant slides to visits from the St. Louis Fire and Police Department, we’re grateful for the support and another year moving forward.

Today we celebrated two incredible members of the Gutmann lab. We'll miss Alex’s cooking tips and Talia’s humor, but we’re excited for all that lies ahead on their next adventures!

Another year, another cherised lab photo! We are excited to see some colleagues embark on new journeys and we warmly welcome our newest members. What never changes is our commitment to a happy and collaborative research environment. #Researchteam #lablife

This week we have said, "See you later" (never goodbye) to an incredible lab member! Chloe has brought joy and amazing work to the lab since her undergrad for more than 4 years. We wish her the best in NYC and her journey to med school.

We are so happy to have our friends from Penny's Flight Foundation visit last week! It was wonderful sharing the exciting NF1 research currently happening in the lab. We're so grateful for their dedication to raising NF awareness, supporting patients, and championing research. #nf1 🦋

Another celebration for the Gutmann Lab! Today, one of our newest undergrads, Paulina, makes her debut into the 20s. We are excited to have her for the summer and support her on her scientific journey next year. Happy Birthday Paulina! 🎉

Today, we celebrate the journey of two amazing trainees in the lab. They have great things coming into their future, and we are equally sad and proud to see them go. Wherever their paths may take them, the Gutmann lab will always be their home.
Good luck, Laura and Xuanwei!

The Gutmann Lab celebrates Giving Day at WashU Medical Campus!
In these hard times, our gratitude and donations are more important than ever. A community that supports and helps each other can handle anything that comes their way. #givingday

Gilbert Family Foundation for science. #NF1.

I'm glad to be back in my hometown. Detroit. Michigan. Cliff Bells for jazz.

True pioneers. Well deserved.

Tesla Recalls Every Single Cybertruck Over Stainless Steel Trims Falling Off | Carscoops 151 Cybertruck owners filed warranty claims after noticing the roof trim panel above the windows was coming loose

Tesla has recalled... every single Cybertruck. Every one they've ever sold. For a hardware issue

www.carscoops.com/2025/03/tesl...

👋

Celebrating with #Lars #Danielsson on the stereo!

Who's got it better than us??? #BigTen champions!!!