mspcf

🧪 Chem(bio) friends, this one is big!!🔥
@irbbarcelona.org is opening a Group Leader position in Chemical Biology! 💜

If your research plan and vision are at the interface of synthetic chemistry, chemical biology, and biomedicine, please check the call!
👇
recruitment.irbbarcelona.org/jobs/7334978...

Now in @cellpress.bsky.social: We profiled cerebrospinal fluid proteomes from 5,000 neurology patients by mass spectrometry — mapping protein changes across stroke, brain cancer, infections & autoimmune diseases, revealing shared and disease-specific signatures.
www.sciencedirect.com/science/arti...

(3/3) It has been possible thanks to the collaboration of many institutions (@idibaps.bsky.social, @isciiisalud.bsky.social, @irsantpau.bsky.social, @uab.cat, @ub.edu, @irbbarcelona.org...). We contributed by generating and analysing the #Proteomics data. It's been a pleasure collaborating with you!

(2/3) The work entitled “TfR1 deficiency beyond combined immunodeficiency. Pivotal role of mitochondrial function and iron-sulfur cluster biogenesis in disease pathogenesis” reports that disease-associated #TfR1 variants ( #Uniprot #P02786 ) are also linked with severe mitochondrial dysfunction.

TfR1 deficiency beyond combined immunodeficiency. Pivotal role of mitochondrial function and iron-sulfur cluster biogenesis in disease pathogenesis.

(1/3) Keep going! Congratulations to Gerard Muñoz, Elise Huisman, Frederic Tort, Antònia Ribes and all the team behind their last paper recently published in the “Genes & Diseases” journal ➡ www.sciencedirect.com/science/arti...

Una ventana al organismo para estudiar la vida secreta de las células Imagine poder tener una ventana abierta al interior del organismo, un mirador que permitiera contemplar lo que ocurre dentro de los tejidos, mostrando con detalle la vida de las...

(3/3) We even appear in the press! What a hype! 😱 @elmundo.es.web.brid.gy @elmundoes.bsky.social

➡️ www.elmundo.es/ciencia-y-sa...

#MassSpectrometry #Proteomics #SingleCell

IRB Barcelona launches Spain’s first fully integrated Spatial Omics Platform Spatial omics is a new generation of technologies that allow scientists to study cells in their original location within tissues (without isolating or moving them from their environment). Just as a ci...

(2/3) Here you can read the official @irbbarcelona.org announcement to have all the details 🧐:

➡️ www.irbbarcelona.org/en/news/inst...

Spatial Omics Platform: How IRB Barcelona is Mapping Disease at the Cellular Level YouTube video by IRB Barcelona

(1/3) Breaking news! @irbbarcelona.org launches the #Spatial #Omics #Platform! Watch the cool promo video featuring some of our staff members 🥰 and newest instruments 🧪:

➡️ youtu.be/3H-SHvLStfs?...

@brukercorporation.bsky.social @brukerspatial.bsky.social @evosep.bsky.social

Join us in March for #Proteomics and networking in the beautiful #Nuuksio National Park! We will cover #PlantProteomics, #MicrobialProteomics, and #MammalianProteomics, for current and potential future users. Welcome!
@eupaproteomics.bsky.social

🏆 EuPA Awards 2026 – Applications Open!
Are you pushing the boundaries in proteomics?
Or do you know someone whose work truly deserves recognition?
📅 Applications open: 18 December 2025
⏳ Deadline: 14 February 2026
🖥️ Information: eupa.org/eupa-awards-...

(2/2) All the MSPCF team wish you a superb #8bit #retro #xmas and an electronic #2026 #newyear!

(1/2) Ready for @irbbarcelona.org 2025 Lab Door Decoration Contest! This year we get inspired by the #retrogaming culture and its cool #pixelart aesthetic. Hope you like it! Follow the #IRBBarcelona Insta link below and support us with lots of likes!

www.instagram.com/p/DSUcrwIjEi...

Efficacy of a drug demonstrated in preclinical models to halt #rhabdomyosarcoma growth

A study led by @sjdhospitalbarcelona.org and @hospitaldelmar.bsky.social Research Institute, published in
@natcomms.nature.com

#pediatric #cancer #oncologia #recerca #TalentMAR

researchmar.net/news/782/eff...

A study published in Nature Communications by @crg.eu and @bsc-cns.bsky.social shows that human gene maps lack global representation because they were built mainly using data from individuals of European ancestry.
bist.eu/human-gene-m...

Un estudio del #IRBBarcelona (@batllelab.bsky.social) y el @cnag-eu.bsky.social revela cómo los tumores colorrectales metastásicos bloquean el sistema inmunitario mediante dos mecanismos complementarios.

Publicado en @natgenet.nature.com

Crédito vídeo: @3catinfo.bsky.social 

🧪

(4/4) #XLMS results support the structural analyses done by Eva’s team, which uncovered how the #GlucocorticoidReceptor (GR) self-assembles into its active forms. This deepens into the understanding of disease-linked GR mutations and establishes a framework for designing selective GR modulators.

(3/4) We are happy to have contributed by generating the #CrossLinkingMS ( #XLMS ) data and also by using our custom data analysis workflow, which integrates the outputs of different #XLMS software like #MeroX, #xiSEARCH and #XlinkX. @irbbarcelona.org

The multimerization pathway of the glucocorticoid receptor Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf

(2/4) The job, entitled “The multimerization pathway of the glucocorticoid receptor” has been published in @narjournal.bsky.social. Have a look at it!

academic.oup.com/nar/article/...

Researchers decipher a mechanism that determines the complexity of the glucocorticoid receptor

(1/4) Congrats @estebanezlab.bsky.social & team for your new paper deciphering the mechanism determining #GlucocorticoidReceptor complex @bqbiomedmolub.bsky.social @biologiaub.bsky.social

web.ub.edu/en/web/actua...

Congrats Drs. Batlle, Supek, Zorzano, Orozco, López Bigas, A. González, Wculek, Nebreda, Salvatella, Palacín & Gabaldon, all among the world’s most cited in the World’s Top 2% Scientists in Stanford University–Elsevier list!. Drs. C. González & Aloy among the most cited scientists in their careers!🙌

UniProt UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.

(5/5) As a result, the work lead by Frederic and Antònia shed a bit more light on #COX4I1 ( #UniProt link → www.uniprot.org/uniprotkb/P1... ), and its role in #LeighSyndrome, a condition that affects approximately 1 in 40,000 live births.

(4/5) We contributed by generating the #Proteomics data and by combining our custom data analysis workflow with a supercool tool called #ProtRider (@gagneurlab.bsky.social), which has a strong potential to study #RareDiseases, or any other case in which the number of bioreps available is limited.

(3/5) Among these institutions → @hospitalclinic.bsky.social, @idibaps.bsky.social, @isciiisalud.bsky.social, @ub.edu, @irsantpau.bsky.social, Hospital Universitario Cruces, @um.es, @uab.cat and @irbbarcelona.org.

(2/5) The job, entitled “Complex IV deficiency due to COX4I1 deep intronic and de novo variants results in progressive motor impairment and Leigh syndrome” has been possible thanks to the collaboration of multiple institutions.

(1/5) So exciting! Congratulations to Frederic Tort, Antònia Ribes and all the team behind their new paper, which has been recently published in the #Mitochondrion journal:

doi.org/10.1016/j.mi...

🧬 Publicado en @jamaoncology.com: un grupo internacional de expertos, liderado por el Dr. César Serrano (#VHIO), publica la primera guía de recomendaciones del uso de la secuenciación genómica en el manejo de pacientes con #sarcoma

➡️ https://linke.to/SerranoJAMAVHIO_Cast

@cerca.cat

🧵1/ 
🔬 Un avenç en medicina regenerativa: científics de l’#IBEC han aconseguit implantar mini-ronyons humans en ronyons de porc i mantenir-los funcionals. 
 
Un nou pas cap al futur dels trasplantaments. T’ho expliquem 👇

(2/2) Many thanks to Amanda Demeter, Fabiana Izaguirre & Guillermo Heins from the #Cellenion team for the great training and support! Still more to come and exciting science ahead… Stay tuned!

#MassSpectrometry #CoreFacilities

(1/2) #SingleCellProteomics and #SpatialProteomics… Here we go! We’ve just completed the training on the Cellen One system. Another big leap towards the new era of high-sensitivity #Proteomics at @irbbarcelona.org

🧪 Out in @nature.com:  Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

 ✍️ #IRBBarcelona & University of Washington

📌 DOI: 10.1038/s41586-025-09521-x

Video credits: 3CatInfo, Som3cat

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social