Alejandro Brenes

MMR (measles, mumps and rubella) vaccine Find out about the MMR vaccine for measles, mumps and rubella, including who should have it, when it's given and possible side effects.

Measles is one of the most highly infectious diseases, and it can make children seriously unwell.

But it is preventable.

Protect yourself and others by ensuring you’re up to date with your and your children’s MMRV vaccines.

Hey ChatGPT, write me a fictional paper: these LLMs are willing to commit academic fraud Mainstream chatbots presented varying levels of resistance to deliberate requests for fabrication, study finds.

"All major LLMs can be used to either commit academic fraud or facilitate junk science...guard rails are easily circumvented"

Is anyone surprised? www.nature.com/articles/d41...

Armed and ready: How Alejandro Brenes is uncovering the hidden lives of neutrophils in brain cancer Dr. Alejandro Brenes, a Wellcome Trust Early Career Fellow at the University of Edinburgh’s Institute for Regeneration and Repair, is uncovering hidden neutrophil populations in glioblastoma that coul...

Single-cell proteomics revealed neutrophil populations in glioblastoma that transcriptomics missed. Some may be blocking blood vessels & worsening outcomes. @ajbrenes.com on the hidden complexity of "soldier cells" & his journey from accidental researcher to Wellcome Trust fellow: bit.ly/46HuIGu

As journalists working today many of us are taught to recognise disinformation when we see it and fight back against it.

Unfortunately there are some who willingly seek it out and put it on their front pages. A disgrace to the profession.

Intermittent fasting evicts long-lived plasma cells from survival niche Nature Reviews Immunology, Published online: 27 February 2026; doi:10.1038/s41577-026-01286-2Zhu et al. report in Immunity that ketogenesis resulting from intermittent fasting causes the downregulation of CXCR4 expression on plasma cells, triggering their egress from the bone marrow and impaired humoral immunity.

ICYMI: Intermittent fasting evicts long-lived plasma cells from survival niche

Yikes, you know performance is bad when the figures of merit for the Astral Zoom MS2/Orbitrap MS3 comparison are # of IDs and a PCA.
Please wait until they release a new Tribrid before buying a Thermo TMT instrument (or buy an Eclipse). The Astral Zoom doesn't look suitable for that application.

Make no mistake this is a concerted and organised attempt to completely undermine science and expert opinion. This is Covid denialism on steroids and it’s on all of academia to see this for what it is and push back as strongly as possible

How ‘skull drains’ keep the brain safe from damage and pathogens Nature - Veins in the skull can rearrange their borders to accommodate patrolling immune cells, a strange behaviour called ruffling.

Veins in the skull can rearrange their borders to accommodate patrolling immune cells

go.nature.com/4tLrKul

Excited we renewed our long-term relationship with Sciex to ensure our software tools Skyline, MSConvert, Panorama, AutoQC, etc... work seamlessly with Sciex hardware. We have big plans for Skyline in the upcoming year.

Talisker tides, Isle of Skye #Scotland #IsleofSkye #Talisker www.damianshields.com

We're live-watching the 21st century version of authoritarian propaganda. Facebook, of course, was the pioneer.
doi.org/10.1038/s415...

20th century totalitarians had to do with newspapers, radio, TV.

We’ve all had samples where BCA/qubit quant correlates poorly with LC-MS TIC.
Looks like those assays aren’t always needed:
“protein quantification and physical normalization steps can be omitted…without incurring an unacceptable increase in measurement variability after computational normalization”

I just did the dumbest thing of my entire career to prove a much more serious point.

I tricked ChatGPT and Google, and made them tell other users I’m a competitive hot-dog-eating world champion

People are using this trick on a massive scale to make AI tell you lies. I’ll explain how I did it

I've seen several recent preprints using DIANN v1.9. DIANN is great and stable in several versions, except for v1.9. We tested at least 7 different versions in a publication 👉 pubs.acs.org/doi/10.1021/...
v1.9 will likely provide more IDs, but at the cost of precision.

Poly-ubiquitylated proteins proved trickier to purify for LC-MS than expected. Non-specific background swamped isolations: with histones and uncertainty!

This led us to develop Ubi-SCAPE—for characterising the poly-ubiquitylome to unprecedented purity and depth.
www.biorxiv.org/content/10.6...

This- 👇👇👇💯. I am always amazed how easily folks are swayed by CVs, without onboarding how the individual will interface with the ‘team’ now and going forward. How a hot ‘technique’ is never enough to tank a thriving collaborative ecosystem…

Amazing how much they've improved ubder Gonzalo. They werw close today

An AI Agent Published a Hit Piece on Me Summary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin…

AI agent goes nuts on open source maintainer after having its pull request denied. This is a pretty insane story. Open source development as we've been used to for the last few decades is likely over. 1/
theshamblog.com/an-ai-agent-...

If you want to know what Reform would be like in power, look at how it threatened Bangor University | Gaby Hinsliff A debating society didn’t want to invite two figures connected to the party to speak. Cue an authoritarian response, says Guardian columnist Gaby Hinsliff

The future of universities is precarious as it is but what has happened with Bangor Uni attacks from Reform following their decision to not allow a Reform person to talk there should be a wake up call for how Reform may ape Trump’s anti- university style

Its not just an acute phase protein. Neutrophils in the blood have like 700,000 copies each

You're sandwiched between @cashwood.proteaglyco.com and @nmriley.bsky.social are you secretely a glyco fan? 🤔

First up @biomarkella.bsky.social a first-year PhD student in the @emmottlab.bsky.social undertaking a PhD project in partnership with Cellenion.
Her research focuses on extending single-cell proteomics to study viral infection, with interest in lipid dysregulation and a focus on coronaviruses.

https://bluesky-map.theo.io/ diagram showing proteomics and mass spectrometry reseaechers.

I'm in pretty good company in this map. bluesky-map.theo.io

#proteomics #massspec

Missed a chance to coin 'Starmer fights to regain control over party after McSwexit'

Plus some have gibberish when you zoom in, AI attempts at random lines which are not letters. Not sure it does much dor the journal to have that

The wasteful nature of the closed peer review cycle was a key motivation for projects like @embo.org's @reviewcommons.org project.
When I spoke with Maria Leptin about it for the EMBO Podcast a few years ago, that was the quote I pulled for the title"The idea was not to waste reviews"

Conflicted, have always like JPR but the AI written paper and the AI cover arts are starting to really put me off

The Muppet sideways eye meme. The average person only owns four bicycles in their life.

So now we have it- not only the reduction from 12-13 to 3 grants from each board recommended for funding but the budget for applicant-led research to be reduced from £200 million to £113 million per year. This is appalling, Especially given all that is happening with medical research in the US.

Is this related to currently only selecting the top 3 and maybe back to normal when calls reopen?