Darrell Kotton

Congrats to first author, Dr. Andrea Alber, co-senior-author Dr. Kostas Alysandratos, and all the team @crem-boston.bsky.social . For patients with pulmonary fibrosis this new human model system should help propel drug discovery and therapeutic development. #helpisontheway! #itsthecells!

The Kotton Lab is pleased to announce our latest work, just posted at biorxiv:
Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis
www.biorxiv.org/content/10.6...

Special thanks to first author, Aaron Dobie
@crem-boston.bsky.social
and senior author James Monaghan
@northeasternu.bsky.social

Just out @ajrcmb.bsky.social,
our review of how axolotl salamander lung regeneration offers many hints for advancing human lung regeneration research for our patients:
atsjournals.org/doi/abs/10.1...

Yesterday, October 7, Sir John Gurdon passed away.
Dr. Gurdon was awarded the Nobel Prize in Physiology or Medicine in 2012, together with Shinya Yamanaka.
Through a series of experiments using Xenopus eggs, Gurdon showed that the nucleus of a mature cell can be reprogrammed to a pluripotent state.

Delighted to give a talk at the Vermont Lung Stem Cell Conference last week.

Also got to visit with @kottond.bsky.social, Finn Hawkins, Joe Kaserman, and Kostas Alysandratos - all legends of the lung regeneration field at the CReM Boston University
@crem-boston.bsky.social

#CureIPF

Thrilled to host Dr. Hao Zhu
@crem-boston.bsky.social
as this year's 10th anniversary Annual Anita Kurmann Memorial Lecturer! Inspiring science from the
@Zhu_Lab
in Anita's honor. #itsthecells

Excited to help spread the word about the latest advances in stem cell research! #itsthecells!

One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies Dr. Elizabeth Taglauer uses lung cells to study placental biology and how the placenta can disrupt babies’ development in preeclampsia.

Great research by our own, Dr. Elizabeth Taglauer @The_BMC @CReM_Boston, featured today: "One NICU Doctor Is Finding the Cellular Clues to Preeclampsia’s Impact on Babies" healthcity.bmc.org/one-nicu-doc... #itsthecells #helpisontheway!

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

Announcing our latest publication, just out today
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...

“David Baltimore, a biologist who in 1975 won a Nobel Prize for a startling discovery that seemed to rock the foundations of the fledgling field of molecular biology, died on Saturday at his home in Woods Hole, Mass. He was 87.”🧪🩺

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...

An incredible advance in regenerative medicine, published this week: Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM: www.nejm.org/doi/full/10....

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

Another impressive clinical accomplishment thanks to regenerative medicine research, just out @NEJM: #itsthecells! #helpisontheway! Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | www.nejm.org/doi/full/10....

So great to be together with so many @CReM_Boston alumni and current members at the #2025LungGRC!

The #RespirERA IHU was out in force at the #2025LungGRC in Lucca with Manon Durandy, Laetitia Seguin (IRCAN) and @laure-em.bsky.social #IPMC Great science, wonderful exchanges with old colleagues and new connections and what a gorgeous place ! #LungResearch

Farewell #2025LungGRC! Great memories as we say farewell, handing off the ball to our new Chairs. #2025LungGRC. @GordonConf

The traditional epithelium vs mesenchyme soccer game, won this year by a new team, Bronchospurs at the 2025 Lung Gordon Research Conference! #2025LungGRC. @GordonConf

Today we officially hand over our meeting Chair roles to the next Chairs: Drs. Cardoso and Crotty Alexander on Day 5 of the 2025 Lung Gordon Research Conference. Special thanks to Dr. Sue Majka, current Chair!

And we are live at the #grclung2025 in Tuscany!

Our latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids Recapitulating the concurrent development of germ layers through the co-differentiation of mesoderm and endoderm within a single spheroid enabled the generation of vascularized lung and intestinal org...

Congrats @MingxiaGu and all the teams collaborating on this latest advance in stem cell and lung organoid research, just out @CellCellPress! and thanks for including our iPSCs! www.cell.com/cell/fulltex...

Off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results An off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results, according to a new study.

Truly amazing pluripotent stem cell clinical trial results for diabetes! “Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results”. Also published in ⁦‪@NEJM‬⁩ this week. #helpisontheway!
www.statnews.com/2025/06/20/s...

RFK Jr. says he may bar scientists from publishing in top medical journals Health Secretary Robert F. Kennedy Jr. took aim at reputed journals such as the Lancet and said his agency will create “in-house” publications instead.

RFK Jr. plans to bar NIH scientists from top journals like NEJM & JAMA, replacing them with government-run outlets.

This would delegitimize taxpayer-funded research, warns Dr. Adam Gaffney of Harvard Medical School.

www.washingtonpost.com/health/2025/...

F.D.A. Approves Novavax Covid Vaccine With Stricter New Conditions

“This is incredibly disappointing,” said Dr. Camille Kotton, an infectious diseases physician who cares for immunocompromised patients, and a former adviser to the CDC

”I don’t know why they would make this restriction; I don’t know of any indication to make this change,”

World's First Patient Treated with Personalized CRISPR Therapy In a historic medical breakthrough, a child diagnosed with a rare genetic disorder has been successfully treated with a customized CRISPR gene editing therapy by a team at Children’s Hospital of Phila...

An amazing clinical triumph for regenerative medicine! A great example of how federal funding results in patient cures. Let’s keep these stories going, America! “World's First Patient Treated with Personalized CRISPR Therapy” #helpisontheway!

www.pennmedicine.org/news/news-re...

The ATS is pleased to recognize Lauren Kearney, MD, as the 2025 Ziskind Clinical Research Scholar Award winner. Dr. Kearney aims to advance early detection of lung cancer, increase access to preventive care and treatment, and reduce health disparities.

Read more: www.thoracic.org/professional...

"There is perhaps no better demonstration of the folly of human conceits than this distant image of our tiny world. To me, it underscores our responsibility to deal more kindly with one another, and to preserve and cherish the pale blue dot, the only home we've ever known." - Carl Sagan

We are so proud of our director, @kottond.bsky.social, for being awarded BU’s Innovator of the Year!

So grateful to all our team- current and past graduates of our lab — and to all the 10 faculty leaders who each lead teams of innovators at the CReM #itsthecells!

America don't let up now. Preserve the NIH funding that lets us train the next generation of scientists and researchers!
Carl Sagan would have said the same! bsky.app/profile/saga...