@roelfesgroup
Interdisciplinary group at the University of Groningen @rug.nl working on Artificial Enzymes, Bioorthogonal Catalysis and Chemistry in Living Cells. Posts by group members. https://sites.google.com/rug.nl/roelfesgroup/
Last week I had the pleasure of attending the Netherlands’ Catalysis and Chemistry Conference (NCCC), where I presented my research on photobiocatalytic atroposelective biaryl coupling.
I’m excited to share that I was awarded the Royal Society of Chemistry @rsc.org EES Catalysis Best Talk Prize!
📣 Thrilled to announce our incredible speaker lineup for the 2026 edition of #ETOC Online Symposium on April 29-30th.🗓️ Join us by registering today and to stay up-to-date! : tinyurl.com/ETOC2026-reg... (1/3)
🥳🥳🥳 Our study on engineering enzymes to break C–F bonds is out in @angewandtechemie.bsky.social. Congrats to the brilliant & dedicated @suzannejansen.bsky.social for taking this step toward the remediation of #PFAS & other contaminating organofluorides!
onlinelibrary.wiley.com/doi/10.1002/...
Season’s greetings from the Roelfes and Mayer groups! 🎉🎄
Warm wishes to our colleagues, collaborators, and friends across the community for a joyful holiday season and an inspiring New Year ahead. ✨🧪
Our postdoc Valeria Poggetti @valeriapoggetti.bsky.social presented her work on Nucleophilic Catalysis in Thiophenol-Based Designer Enzymes at #NWOChains
@stratinghinst.bsky.social @rug.nl
Last week I have defended my PhD in the beautiful Aula of the @rug.nl with a thesis entitled "Mapping the Sequence Landscape of an Artificial Enzyme". Such a huge diploma is proportionate to the immensely beautiful experience behind a PhD in the @roelfesgroup.bsky.social. Thank you very much to all!
Upper half of a PhD position accountment in the field of biochemistry.
Lower half of a PhD position accountment in the field of biochemistry.
I am looking for a PhD student interested in enzymes!
For the full annoucement: www.chemzymes.com
📢📢 New paper out!
AI and networks can be used to predict distal mutations in proteins, even in artificial enzymes!
Check out the article here
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With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzannejansen.bsky.social, who has outdone herself in this project! (1/5)
www.biorxiv.org/content/10.1...
Our postdoc @francdefel.bsky.social just gave a fantastic talk on gold-based artificial metalloenzymes for asymmetric catalysis. #Biotrans2025
@stratinghinst.bsky.social @rug.nl
Please also check posters 007 and 257 to find out more about radical biocatalysis and leveraging epistasis efficiently in artificial enzymes, respectively.
@stratinghinst.bsky.social
#Biotrans2025 Gerard just gave an overview on recent advances in non-canonical amino acids application for novel artificial (metallo)enzymes from our group.
#RepArtZymes pre-conference in Basel also brought together some of our old and current group members.
@zhizhou1619.bsky.social @reubenlg.bsky.social
Our group members are attending #RepArtZymes Biotrans 2025 pre-conference. Gerard just presented our work on Artificial Metalloenzymes Featuring Thiol-Based Amino Acids. Compliments to the organisers #WardGroup for the fantastic program and a great get-together of the key players in our field.
Great experience at the Green Chemistry & Engineering Conference! Amazing time around a neat program.
Extremely grateful for giving me the chance to share my work in an environment that pushes towards sustainable research
#GreenChemistry #MSCA
@acsgci.bsky.social @roelfesgroup.bsky.social
📢📢📢 PhD Opportunity!
Join our research group at RUG! We're seeking a motivated PhD student for a project on biocatalytic cascade processes combining natural and designer enzymes, supported by machine learning.
Click below to learn more — and feel free to share!
sites.google.com/rug.nl/roelf...
Very proud to share that one of my main PhD projects has been published in @chemicalscience.rsc.org, and that it has been selected as a #ChemSciPicks of the week paper!
Keep reading below for more details, or check out the full paper for free online: doi.org/10.1039/D5SC...
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Check out this week’s #ChemSciPicks from Gerard Roelfes (@roelfesgroup.bsky.social, @stratinghinst.bsky.social) et al.!
‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’
Read it here for free: doi.org/10.1039/D5SC...
#ChemSky 🧪
Had an amazing week at #ACSSpring2025! It was an intense but incredibly rewarding experience with top speakers and insightful discussions. I'm grateful for the opportunity to present my research in the biocatalysis session - awesome interaction! #MSCA @roelfesgroup.bsky.social
Had an amazing week at the MetRaZymes @metrazymes.bsky.social Winter School in Hirschegg, Austria! It was a pleasure to learn, share, and connect with fellow researchers in our doctoral network. We organized and attended insightful lectures and workshops on ⬇️🧵
A spaceship as an allegory to an independent, self recycling system.
We are announcing about 30 PhD positions in the @fwf-at.bsky.social Cluster of Excellence Circular Bioengineering www.circularbioengineering.at/jobs
9 projects open in Progamme 2 (Self-Sustainable Microbial Systems) in 4 Austrian Universities
@stratinghinst.bsky.social
@unigroningen.bsky.social
Huge congratulations to our former PhD student Reuben @reubenlg.bsky.social on winning the KNCV-DCS Thesis Award from the Dutch Catalysis Society for his outstanding PhD research in our group! A well-deserved recognition of his hard work and dedication. 🎉
Tanja presented her work on metallaphotoredox catalysis in designer photoenzymes.
Congrats to both of you!
@stratinghinst.bsky.social @unigroningen.bsky.social
Our group members Tanja and Franco @francdefel.bsky.social presented their exciting research at NCCC this week.
Franco talked about his work on asymmetric catalysis in gold-based artificial metalloenzymes.
This accomplishment would not have been possible without the tireless work of Ru Jiang and @fabricas.bsky.social and the expertise of Andy-Mark Thunnissen in solving the holoenzyme structure.
Great work everyone! 🏆
The excellent properties of the evolved artificial metalloenzyme enabled its application in preparative-scale synthesis, yielding valuable synthons for the production of pharmaceutical compounds.
Using a magnetic bead-based assay, we successfully evolved this newly-generated biocatalyst, achieving perfect enantioselectivity and high yields in the asymmetric new-to-nature addition to nitroalkenes.
Our latest publication is out in @angewandtechemie.bsky.social!
We generated and engineered a novel artificial metalloenzyme for the enantioselective synthesis of a panel of γ-nitro-carbonyl compounds on a preparative scale.
