Institute for Protein Innovation

Protein design: how scientists are creating tailor-made molecules to tackle major challenges | Science Arena Using computational models and AI, scientists are developing proteins to address scientific and technological challenges.

"AI isn't smart enough to provide the ultimate solution to a problem, but it's very good at finding alternative solutions," says André Teixeira, senior director of the IPI #antibody platform. Read more from Teixeira and others in this Science Arena rundown on #AI and #proteindesign.

Apply now for our 2026 Yeast Display Technology for Antibody Discovery course! buff.ly/KuyAKw3

Highlights include:
▪️ Lab sessions on library prep, biotinylation, MACS & FACS
▪️ Lectures on principles, applications and methods of yeast display
▪️ Seminars from invited experts on display technology

His next big idea might emerge from something small: Stephen Quake joins IPI Board Biophysicist Stephen Quake has held many titles. He’s invented devices, developed diagnostics and launched companies. He’s won dozens of prizes and been

IPI welcomes Stanford biophysicist Stephen Quake to our Board of Directors!

He brings a wealth of experience with HHMI, CZI and more, and his unique perspective will be instrumental in launching the next era of protein science.

Read more: buff.ly/9coNPo2

Multiple protein structure alignment at scale with FoldMason Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended…

A team at Seoul National University (@martinsteinegger.bsky.social) recently introduced FoldMason @science.org—an open-source tool to compare MSTA of 1000s of proteins. We see big potential to analyze proteins w/ conserved structure & limited sequence conservation

2026 Yeast Display Technology for Antibody Discovery A five-day course in June 2026 combining lectures and hands-on laboratory sections to train participants in the core principles of yeast display technology.

Scientific progress is built on shared knowledge, accessible learning, and hands-on training. So this June we’re teaching a 5 day immersive course on the #yeastdisplay principles, applications and practical workflows that drive our #antibodydiscovery campaigns.

Apply by March 30 ⬇️
buff.ly/n8crLD0

That's right. Feel free to reach out to us at antibodies@proteininnovation.org with any additional questions!

You can find more data here:
NRXN3α - proteininnovation.org/wp-content/u...
NRXN3β - proteininnovation.org/wp-content/u...

Thanks for the question, @ruizhao.bsky.social! We anticipate them to be distinct for -alpha and -beta forms as our anti-NRXN3α was generated against the LNS1-EGF1-LNS2 region of NRXN3α (not conserved with NRXN3β), while our anti-NRXN3β was generated against the extracellular domain of NRXN3β.

Homepage Discover innovative protein science solutions designed to drive biomedical research and improve human health. Explore our antibodies, learning opportunities and research today.

And we just spruced up our website — go take a look! buff.ly/tmAtd0L

We showed up @slasorg.bsky.social in force, with multiple posters and countless discussions about cool robots and efficient protein science methods.

We ran a liquid handling essentials short course at #2026SLAS @slasorg.bsky.social, alongside instructors from Hamilton, Agilent Technologies and Artel - Advanced Instruments.

We released new Neurexin, Neuroligin, Netrin, DCC and PUNC antibodies with lots of characterization work & data to assess their performance — shout out to our partner @addgene.bsky.social.

(You can find all our Abs here: buff.ly/TsqcTVF)

Is it only March? It’s been a busy year so far!

We kicked off the year hosting a lab automation course with HMS MEDscienceWorks at Emmanuel College.

One month left to apply to our hands-on #yeastdisplay course!

Learn more ➡️ buff.ly/XpRYLOC

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.  Proteins posi

Note: These are highly selective recombinant monoclonals, useful for researchers studying synapse formation, maintenance or neurotransmission. All validation and characterization data can be found in our catalogs: buff.ly/G0bQxV3

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.  Proteins posi

New Neurexin and Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection, available through @addgene.bsky.social:

🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3

View more data ➡️ buff.ly/YYL1WWE

Mapping targetable sites on the human surfaceome for the design of novel binders | PNAS The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo pro...

A new @pnas.org study caught the eye of our bioinformatics team with its identification of ~4,500 targetable binding sites & binding seeds across human cell surface proteins—giving IPI and other labs a protein design launch point.

Head to our website for more info 🧑‍🔬 buff.ly/lag7LwW

Applications for our 2026 Yeast Display Technology for Antibody Discovery course are due on March 30th. Here’s what you need to know!

Apply now! buff.ly/lag7LwW

Education We believe scientific progress arises from a strong foundation of shared knowledge, accessible learning and tailored training. Our Education Program provides pr

Learn more about IPI education programs here: buff.ly/Q9iAHkq

Thanks @slasorg.bsky.social for providing a wonderful forum for discussion!

👉 Across roles and experience levels, the most important traits of successful automation professionals were remarkably consistent: curiosity, adaptability, flexibility and a willingness to troubleshoot.

What did we miss? We’d love to hear your perspectives.

👉AI — and especially the combination of AI + automation — was a major theme. Many expected AI to enable and empower the workforce, but there was also skepticism about the pace of the progress and concerns about bias in training data.

👉 There’s a clear disconnect between job descriptions and the skills hiring managers actually need. We’ve joined an automation education guidelines working group, alongside representatives from Carnegie Mellon and Duke, to help bridge this gap.

👉 There is a ton of energy and interest in addressing workforce gaps in laboratory automation and broad agreement that the field isn’t limited by technology — but by talent availability.

Attending #SLAS2026 earlier this month was incredibly valuable for our Automation and Education teams as we think about how to build new resources for lab automation training. Here are a few of our biggest takeaways:

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.  Proteins posi

Note: These are highly selective recombinant monoclonals, useful for researchers studying synapse formation, maintenance or neurotransmission. All validation and characterization data can be found in our catalogs: buff.ly/G0bQxV3

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.  Proteins posi

New #Neurexin and #Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection today, available through @addgene.bsky.social —

🔹 IPI-NRXN1α
🔹 IPI-NRXN2α
🔹 IPI-NRXN3α
🔹 IPI-NLGN2
🔹 IPI-NLGN3

buff.ly/YYL1WWE

Synaptic cleft antibody collection Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.  Proteins posi

Note: These are highly selective recombinant monoclonals, useful for researchers studying synapse formation, maintenance or neurotransmission. All validation and characterization data can be found in our catalogs: buff.ly/G0bQxV3

2026 Yeast Display Technology for Antibody Discovery A five-day course in June 2026 combining lectures and hands-on laboratory sections to train participants in the core principles of yeast display technology.

We perform the process daily — and want to share our tips and tricks, so you can bring the same skills into your lab.

Think this could help with your research? Learn more about Yeast Display Technology for Antibody Discovery and apply by March 30: buff.ly/ukGnQWJ

What does antibody discovery mean at IPI?

It means using FACS and MACS to winnow a vast yeast synthetic library, with 10^10 unique sequences, down to just a few highly selective, tight-binding antibodies that hold potential as research reagents and therapeutics.