Our circadian clock and cancer chronotherapy, a terrific
@scripps.edu review, open-access, related to below!
jci.org/articles/vie...

Cytokines are tricky to study, let alone in vivo. New tool to study cells that respond to cytokine receptor activation

Beautiful work and beautiful images.

Somatic evolution following cancer treatment in normal tissue - Nature High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

Nature research paper: Somatic evolution following cancer treatment in normal tissue

go.nature.com/48MhLvf

And we do not yet know what the impact will be on the rest of their lives.

If you are interested in how oncogenic RAS signalling influences the immune landscape of lung adenocarcinoma, our latest preprint on the subject is out on @biorxiv-cancer.bsky.social

#KRAS #lung #immuno-oncology #preprint 🧪

Paul Nurse describing the main job of a PI

(From ‘The Thinking Game’, 2024)

A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...

Cell plasticity as a mechanism to evade KRAS inhibition in colorectal cancer.

#KRAS #CellPlasticity #CancerStemCell 🧪

Bravo 👏

#ESMO25
Adam Gripping of @mdanderson.bsky.social discusses association of improved OS in #NSCLC and #Melanoma with administration of a mRNA COVID vaccine

Translational work showing mechanism of increased INF-alpha leading to immune priming

Phase III in development… @oncoalert.bsky.social

Quels progrès dans la lutte contre le cancer ? (2/2) - L'Humanité Les pathologies cancéreuses sont mieux combattues. Les récentes découvertes liées à l’immunothérapie viennent s’ajouter aux thérapies ciblées et géniques. Mais des questions se...

📰 « Quels progrès dans la lutte contre le cancer ? »

@humanite.fr publie la tribune du Pr Fabrice André qui appelle à renforcer la prévention et la recherche sur les causes environnementales et comportementales des cancers, chez les 20-40 ans.↩️

www.humanite.fr/en-debat/can...

Yet another example of negative commercial determinants of health

Sunbeds are known to be especially harmful for young population, increasing the risk of skin cancer by 59%, according to the cancer research agency

And again yet, some governemnts prioritise (commercial) profir over (public) health

If you are looking for a postdoc position in a great lab with a fantastic PI, the Caswell Lab at UCL is recruiting 🙂

This is figure 5 from Wildfire smoke exposure and mortality burden in the US under climate change. It shows the mortality impacts of wildfire smoke PM2.5 and estimated mortality due to smoke 533 PM2.5 under future climate scenarios.

Increases in wildfires are expected to cause a notable increase in premature deaths, according to two studies in Nature.

go.nature.com/4mynauQ
go.nature.com/4nJoxI5
#medsky ⚒️ 🧪

Debbie, you cumulate successes! Congratulations. This is amazing.

Très astucieux. Bravo !

Gustave Roussy toujours 1er centre français et 1er centre européen en oncologie L’excellence de Gustave Roussy est une nouvelle fois reconnue par le magazine américain Newsweek, qui a classé l’Institut 1er centre de lutte contre le cancer en France et en Europe, et parmi les meil...

📰 @gustaveroussy.fr toujours 1er centre français et 1er centre européen en #oncologie.

En savoir plus ⤵

Congrats Emma! Well deserved.

📰 La chercheuse Sophie de Carné nommée Young Leader par le Conseil franco-britannique.

⬇

Congrats @inigolanda.bsky.social and Stephanie Corgnac 👏

📌 great thread.

Lung Cancer Prevention Laboratory Pioneering research in lung cancer to improve diagnosis, treatment and prevention

I am excited to announce that my laboratory @ucl.ac.uk is now open!

We are hiring so please contact us if you are interested.

www.caswelllaboratory.com

Very nice. Where is it?

Join Caetano Reis e Sousa (@reisesousalab.bsky.social) as he describes how our immune systems work and his team’s research into better understanding dendritic cell receptors. www.youtube.com/watch?v=nBC9...

I agree, Larry. I use it to get an overview of something I am not familiar with. I brainstorm with it. I ask for “brutally honest feedback” with a prompt that makes it challenge my thinking.
But I would not make it generate text from scratch. I have tried and it isn’t helpful.

Writing is thinking - Nature Reviews Bioengineering On the value of human-generated scientific writing in the age of large-language models.

Writing is thinking. A reminder on why scientists write, and why we should continue writing in the era of large-language models by Nature Review Bioengineering

@natureportfolio.nature.com
www.nature.com/articles/s44...
#AI #LLM 🧪

Depends… Does it have a bottle opener? 😅

How exercise during pregnancy can improve metabolic health of offspring: a key mediator (Serpina3c) from mother's white adipose tissue gets into fetal circulation, suppresses inflammation, as demonstrated in the mouse model
www.nature.com/articles/s42...
www.nature.com/articles/s42...

Thrilled to announce I'm moving to Manchester to lead the Cancer Origins group! If you're interested in how mutations and exposures drive tumourigenesis — come join the adventure

Very important and timely statement from @miriammerad.bsky.social, president of IUIS.