James Olzmann

Thank you! It was great collaborating with you on this project! 🙌

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - Nature Cell Biology After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out

thttps://www.nature.com/articles/s41556-025-01856-x

#Vitamin B2 is converted into molecules which protect cells from oxidative damage. The downside: It also protects #cancer cells. Scientists at the Rudolf Virchow Centre at #JMU discovered that. 📸 Natalie Fahmer
➡️ www.uni-wuerzburg.de/en/news-and-...

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance - Nature Cell Biology After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B2) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in c...

3/3
Also exciting to see a complementary study from @angelifriedmann.bsky.social @veraskafar.bsky.social & colleagues published in Nature Cell Biol today. Together, our studies highlight a role for vitamin B2 metabolism and FAD in regulating FSP1 and ferroptosis.
www.nature.com/articles/s41...

2/3
Huge congratulations to the entire team for driving this project forward. Grateful for fantastic collaborators, including @theprattgroup.bsky.social and everyone in the lab who contributed to this work.

A true team effort across genetics, cell biology, and chemical biology.

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis - Nature Structural & Molecular Biology Here, Deol et al. use genetic screens in gene-edited reporter cell lines to identify regulators of ferroptosis suppressor protein 1 (FSP1) expression and stability. They show that vitamin B2 metabolis...

1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...

FAD-dependent stabilization of FSP1 promotes ferroptosis resistance Nature Structural & Molecular Biology, Published online: 13 March 2026; doi:10.1038/s41594-026-01760-4The oxidoreductase FSP1 recycles radical-trapping antioxidants that suppress oxidative lipid damage and ferroptosis. A series of genetic screens reveal a key role for the vitamin B2 metabolite flavin adenine dinucleotide in stabilizing FSP1, preventing its proteasomal degradation and promoting ferroptosis suppression.

New online: FAD-dependent stabilization of FSP1 promotes ferroptosis resistance

Thank you! 😊

Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org

Thank you, André! 🙏

Very cool, Hiten! The connection with Brr6 / Brl1 and NPC assembly were a big surprise in this study. Science! :)

Thank you for your important contributions to this paper, Niek! Congrats! 🙌🏽

Cool paper alert 🚨! Congrats @olzmannlab.bsky.social!

Proud to have made a small contribution to this. One of the prettiest membrane-protein structures I have simulated ☺️

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...

Congrats, Jesse! Exciting discovery! 👏

A little late on here but happy to share my 3rd first author paper from grad school finally out in Science Advances!! In collaboration with James Olzmann's group, we find that Tregs utilize FSP1/Aifm2 for preventing lipid peroxide accumulation and preserve their suppressive function in tumor models.

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.

Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...

Thanks for the shout out, Jeremy!! Awesome to be on this list with all these lipid all star papers! ⭐️

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly Imbalances in lipid storage and secretion lead to the accumulation of hepatocyte lipid droplets (LDs) (i.e., hepatic steatosis). Our understanding of the mechanisms that govern the channeling of hepat...

15. And second, also from @olzmannlab.bsky.social, an ER chloride channel pushes LD formation toward the cytosol vs. nucleoplasm and affects nuclear pore complex assembly in @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

14. Two studies that reshape thinking about lipid droplets biology. First, lipid peroxidation can occur to neutral lipids inside the core of LDs, with protective mechanisms revealed, from @mikelangelipid.bsky.social and @olzmannlab.bsky.social in @natcellbio.nature.com www.nature.com/articles/s41...

Spatial barcoding reveals reaction radii and contact-dependent mechanism of proximity labeling - Nature Chemical Biology A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

Assistant Professor - Environmental Impact on Human Metabolic Disease - Nutritional Sciences and Toxicology University of California, Berkeley is hiring. Apply now!

Two weeks left to apply! If you study any area of metabolism or metabolic disease (broadly defined), we encourage you to apply. The dept is excited about biological and molecular mechanisms, metabolic flux, therapeutics, and physiology related to disease.
aprecruit.berkeley.edu/JPF04710

In vivo models bring FSP1 inhibitors to life - Nature Cell Biology FSP1 is a key suppressor of lipid peroxidation and ferroptosis, yet it is largely dispensable in standard cell culture models. Two new studies now show that FSP1 becomes essential for tumour growth in...

Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳
www.nature.com/articles/s41...

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...

The result of a fantastic Iwasa-Drubin lab collaboration.

@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...

Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...

POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004 The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

#NatMetabPicks | In @natcellbio.nature.com led by @olzmannlab.bsky.social ( @ucberkeleyofficial.bsky.social )

FSP1, localized to lipid droplets, protects stored lipids from oxidative damage and prevents ferroptosis.

www.nature.com/articles/s41...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning

#Organelles
#EndoplasmicReticulum
#ER_Literature

FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!

shorturl.at/B5XYD