@the-asci.org
The ASCI is a nonprofit honor society of physician-scientists. Founded in 1908, the Society is home to 3,500+ members across academic medicine and industry. https://the-asci.org Take action for federal funding of research: https://www.fundresearch.org/
Is glucagon action altered in steatotic liver disease? doi.org/10.1172/JCI2...
An Editor’s Note by Raghavendra G. Mirmira @rmirmira.bsky.social on Christie et al.: doi.org/10.1172/JCI2...
The pathogenic contribution of PTPN11 mutations to AML has been unclear
John C. Byrd & team reveal PTPN11 mutations in AML can be early events in the clonal evolution of disease development and are associated with variably differentiated myeloid cells: doi.org/10.1172/jci....
Challenging the dogma…
Here, Adrian Vella & team show hepatic resistance to glucagon’s effects on amino acid catabolism is not a significant factor in postprandial metabolism, regardless of obesity or hepatic steatosis: doi.org/10.1172/JCI2...
ASCI Perspectives: Alessia Fornoni, MD, PhD, and MSTP candidate and Antonio M. Fontanella discuss how Fontanella’s experiences as a patient have influenced his path toward becoming a physician-scientist and inform his patient-focused approach to research
Full video: buff.ly/Pxn1o6t
Congratulations to Meeta Prasad Kerlin (Pulmonary, Allergy & Critical Care) on her election to @the-asci.org! Learn more about Dr. Kerlin & her work here➡️ tinyurl.com/2x9vcbsm @pennldi.bsky.social
Congratulations to Edward Lee (@pennpathlabmed.bsky.social) on his election to @the-asci.org! Learn more about Dr. Lee & his work here➡️ tinyurl.com/4fpvejtd @pennaging.bsky.social
Congratulations to @paralkarlab.bsky.social (@penncancer.bsky.social) on his election to @the-asci.org! Learn more about Dr. Paralkar & his work here➡️ tinyurl.com/5xbwrhf9
Congratulations to @romberglab.bsky.social (@chopresearch.bsky.social/ @pennmedicine.bsky.social) on his election to @the-asci.org! Learn more about Dr. Romberg & his work here➡️ tinyurl.com/432m24m9 @i3h-upenn.bsky.social
Dermal fibroblasts respond to IL-4 and IL-13 and promote T cell recruitment in atopic dermatitis
Challenging the idea that fibroblasts are passive bystanders in atopic dermatitis...
ASCI member Richard L. Gallo & team discover dermal fibroblasts respond to IL4 & IL13, producing Ccr3-binding chemokines, & driving T cell recruitment in atopic dermatitis: doi.org/10.1172/JCI1...
Congratulations to Brian Capell (Dermatology) on his election to @the-asci.org! Learn more about Dr. Capell & his work here➡️ tinyurl.com/mpftnypp @pennepigenetics.bsky.social @penncancer.bsky.social
Congratulations to @ahrensnicklas.bsky.social (@chopresearch.bsky.social/ @pennmedicine.bsky.social) on her election to @the-asci.org! Learn more about Dr. Ahrens-Nicklas & her work here➡️ tinyurl.com/msv9skj4
Shaking out the macrophage role in muscle repair
This issue's cover features work by Hiroshi Takayanagi & team on an activin A-producing macrophage subset that aids muscle repair but can trigger abnormal extraskeletal bone formation in a rare disease context: doi.org/10.1172/JCI1...
Congratulations to the 6 @pennmedicine.bsky.social physician-scientists elected to the American Society for Clinical Investigation (@the-asci.org) class of 2026! Please check back as we profile each new member tinyurl.com/4ejz2cnm
Sequencing has aided in the discovery of mutations in inborn errors of immunity, but their clinical relevance is often unclear
ASCI member Altfeld & team @leibnizliv.bsky.social identify a TLR8 mutation causing immune overactivation & inflammation in 2 siblings: doi.org/10.1172/jci....
Another way SARS-CoV-2 cuts through immune defenses
Zoltan Arany & team identify putative host cleavage targets of the SARS-CoV-2 protease 3CLPro, revealing a mechanism by which the virus weakens host innate immunity in individuals with protective OAS1: doi.org/10.1172/jci....
Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection in macaques
Does suppression of HIV replication protect against severe Mtb infection?
ASCI member Philana Ling Lin & team report on SIV/ART/TB models, finding antiretroviral treatment reduces pulmonary TB pathology, yet does not prevent extrapulmonary spread of TB: doi.org/10.1172/jci....
Can we identify infections earlier after breast implant reconstruction?
@jphendersonmdphd.bsky.social & team profiled postimplantation drain fluid, revealing an infection-associated molecular signature that substantially pre-dated clinical infection diagnosis: doi.org/10.1172/JCI1...
Fanconi anemia confers a high risk of solid tumors, but there has been a lack of preclinical models.
Here, Grandis et al. generate patient-derived xenograft models for FA head & neck cancer and identify precision medicine therapies based on multi-omic profiling: doi.org/10.1172/JCI1...
Birt-Hogg-Dubé syndrome often features lung cysts, but disease models for this phenotype are lacking
Elizabeth P. Henske & team report mTORC1 hyperactivation in cystic lungs from patients & validate its role in lung cyst formation using a new pre-clinical model: doi.org/10.1172/JCI1...
MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype
Non–small cell lung cancer exhibits high rates of brain metastases.
ASCI member Timothy F. Burns (YPSA recipient) & team report MET alterations are enriched in lung adenocarcinoma brain metastases, defining a distinct biologic subtype: doi.org/10.1172/JCI1...
Opening the gates to the blood brain barrier in a high-grade glioma model
Amy B. Heimberger & team find combination the STING agonist 8803 with radiation reprograms the glioma tumor microenvironment, and 8803 induces the opening of the blood-brain barrier: doi.org/10.1172/JCI1...
Join us for ASCI scientific session on March 10th 1-2PM EST:
Dr. Barney S. Graham @msmedu.bsky.social is a thought leader on emerging viral diseases and pandemic preparedness.
Registration: buff.ly/8aotOwA
A target for terminating the long-lived autoimmune response!
ASCI member Maureen A. Su & team find the epigenetic regulator UTX complexes with transcription factors TCF1 & STAT3 to promote pathogenicity of long-lived, stem-like progenitor T cells in T1D models: doi.org/10.1172/JCI1...
Broadly neutralizing antibodies in children with #HIV-1 may have advantages over standard ART
ASCI member Mathias Lichterfeld & team find NK cell profiles were associated with viral rebound and reservoir size in young children with HIV receiving bnAb treatment: doi.org/10.1172/JCI1...
The morning advantage…
Jeffrey A. Haspel & team perform an observational study of 715 patients, reporting a connection between the time of day when CAR T-cell cancer immunotherapy is administered and its effectiveness: doi.org/10.1172/jci....
Predicting chronic graft-versus-host disease
This issue’s cover features work by Sophie Paczesny @sophpacz.bsky.social & team on BIOPREVENT, a tree-based machine learning algorithm developed using data from 1,310 recipients of hematopoietic cell transplants: doi.org/10.1172/JCI1...
After the menopause transition in women with HIV…
ASCI member Peter W. Hunt & team show the effect of sex on the plasma inflammatory proteome in people with HIV is highly dependent on age, with women exhibiting more inflammation than men primarily at older ages: doi.org/10.1172/JCI1...
