This is figure 3, which shows antibiotic use and its associations with abundance of gut microbiome species.
An examination of the association between oral antibiotic use over eight years and the gut #microbiome in Swedish individuals found evidence that antibiotics can have long-lasting impacts on the gut microbiome. go.nature.com/40sw4kU #medsky 🧪
Here's our R package for interacting with WGS derived GWAS summary statistics with many rare variants (from e.g. UKB or AofUs). It uses duckdb underneath so it's fast. Includes some helpful tie ins to Open Targets / Encode Screen / Ensembl APIs for annotation. weinstocklab.github.io/gwasplot/ind...
It was a momentous day — one student that I co-supervise presented her first poster and another submitted her first, first author paper. These days as a mentor make the trials of academia worthwile! ❤️
Brent Pedersen, Mitchell Vollger and I have "posted" our preprint of the manuscript describing bedder, a complement to the functionality of bedtools. The "preprint server" we have chosen is google docs because it was rejected by biorxiv.
docs.google.com/document/d/1...
🚨 New paper! Very excited to have been part of this collaborative work looking at the effect of antibiotics on the gut microbiota even years after prescription. Amazing effort led by Gabriel @tovefall.bsky.social and many others published today in Nature Medicine!
🔗 www.nature.com/articles/s41...
We might hope for clinical testing to be more standardized than consumer services, but if 7 different companies can’t even begin to reach the same conclusion from the same stool sample, we might have problems trusting microbiome data to inform anything health-related.
www.nature.com/articles/s42...
Moved to Claude today!
Title reads: "The destruction that Kennedy has wrought in 1 yr might take generations to repair, and there is little hope for US health and science while he remains at the helm" The cover of the current issue (February 28, 2026, Vol. 407 No. 10531) of The Lancet. Published in the U.K., The Lancet is "one of the world’s oldest (founded 1823), most prestigious, and highest-impact independent general medical journals" in the world.
"HS under Kennedy has made a habit of throwing good money after bad science."
That "good money" is our tax payer $$, thrown at unethical studies. He pushes ideology over evidence.
The cover of the most recent issue of The Lancet says it all.
🧪 www.thelancet.com/journals/lan...
#ImpeachRFKJr
This week's cover @thelancet.com
The Epstein files document what many women researchers have long experienced but rarely seen laid bare so starkly: exclusion operating behind closed doors, shaping who gets funded, invited, mentored, and taken seriously. How many of these networks, norms, and gatekeepers remain in place?
Graphic cover slide titled “Day in the Life: Brooke Wolford, Statistical Geneticist.” Subheading notes she is a faculty member at the Norwegian University of Science and Technology in Trondheim, Norway. Clean, professional layout introducing the series.
Brooke describes starting her day with coffee in bed and checking emails during her 40-minute commute to campus in Trondheim. She mentions living in Norway and beginning work around 8:30 a.m.
Brooke shares that faculty in Norway are required to complete pedagogical training. She attends a session focused on improving teaching practices and supporting student learning.
A day in the life of Brooke Wolford, a statistical geneticist at NTNU (Norway). It's proof that science is both technical and deeply human at the same time. 🧬☕️🐕
👀 Just when I think it can't get worse...
FDA's decision not to accept Moderna's flu vaccine filing has sent shock waves through pharma. "When there’s uncertainty about the path to approval & the reliability of the process, that really has pretty serious consequences,” one player told @jasonmast.bsky.social. www.statnews.com/2026/02/12/f...
I would ask people to call or message their senators about this and specifically that Vinay Prasad needs to be out at FDA. Even the Wall Street Journal has said as much. There is push back. Companies won’t fund clinical trials if they can’t trust the FDA.
Read @bakerdphd.bsky.social’s piece on the need for institutions and their associations to stand up to this kind of behaviour, and then re-read the UNC story.
Very excited to be a certified Carpentries Instructor thanks to Carpentry@UiO! @carpentries.carpentries.org
Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/
New NIH funding strategy has been formalized.
I really do hope scientists understand what this means for the future of science (funding) - it's not subtle.
www.niaid.nih.gov/about/unifie...
I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders.
@jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
No paywall link here: authors.elsevier.com/c/1mWi~7tNuc...
The difference in T2D prevalence increased between the top and bottom deciles of scores associated with fat distribution and insulin resistance (lipodystrophy 1 and 2) in women, and scores associated with obesity and insulin resistance (obesity and hyper insulin) in men (Figure 4).
My fave analysis: To explore pathophysiological pathways, we investigated diabetes prevalence stratified by partitioned polygenic scores from genetic clusters (Smith et al, 2024) believed to reflect different pathophysiological mechanisms.
Our findings suggest an increasing gap in diabetes prevalence between the most and least genetically susceptible. This suggests that people with a high genetic susceptibility to type 2 diabetes could be especially affected by a diabetogenic environment.
The latest article by NTNU PhD candidate Vera Vik Bjarkø, MD led by Bjørn Olav Åsvold is online now! It was fun to contribute to this GxE exploration with a team from the HUNT Center of Molecular and Clinical Epidemiology & Dept of Public Health and Nursing.
How many STEM Ph.D.s were lost from the U.S. federal government last year?
My colleagues @mghersher.bsky.social and @policyhound.bsky.social dug into a recent data release to find the answer. A @science.org exclusive.
www.science.org/content/arti...
A self-described "little farm girl" in the Jim Crow Era, Gladys West's complex and pioneering work for the U.S. Navy helped to improve billions of lives — and keep us from getting lost. n.pr/3YVSGJK
Cost of being female lead/corresponding author in biomedical sciences: "[T]he median amount of time spent under review is 7.4%–14.6% longer for female-authored articles than for male-authored articles" even in disciplines where women well-represented. #AcademicSky
journals.plos.org/plosbiology/...
“The speed, the scope and the severity of the attacks on science are beyond anything we’ve ever seen,” says @gretchentg.bsky.social.
My @nature.com story on the human toll of the 2nd Trump presidency.
Thx to @dochfroehlich.bsky.social, @briannosek.bsky.social, @katharinehayhoe.com & others.
Call on your house representatives to support a FY2026 budget bill that would preserve funding for NIH at the Senate Appropriations Committee approved level of $48.7B and adopt Senate language prohibiting a cap on indirect costs and limiting multi-year funded grants to levels consistent with FY2024
History is a great teacher.
In this piece our own @heidiledford.bsky.social looks at what we can learn from what happened in Japan when vaccine support was withdrawn and how the government is now working to reverse the effects 🧪
#MedSky
www.nature.com/articles/d41...
