Elena Kuzmin

Great work Daniela!

Ancestry and somatic profile indicate acral melanoma origin and prognosis - Nature Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️

www.nature.com/articles/s41...

Rosalind's companion piece to our genetic interactions manuscript. GRAPE, to analyze synthetic lethality screens, and Synulator, to generate simulated synthetic lethal gold standards because none exist today.

www.biorxiv.org/content/10.6...

Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics Nature Communications - Alternative splicing generates diverse protein isoforms, yet the functions of most exons remain unknown. Here, the authors introduce scCHyMErA-Seq, a scalable single-cell...

We’re excited to introduce scCHyMErA-Seq, a scalable #CRISPR-based #exon-deletion screening platform with #single-cell transcriptomic readouts, enabling high-throughput functional analysis of #alternative #splicing. In collaboration with the Gonatopoulos-Pournatzis lab. @natcomms.nature.com

Hallmarks of cancer—Then and now, and beyond Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilities, enabling traits, microenvironmental players, and systemic interactions converge to drive tumorigenesis and proposes that mechanism-guided co-targeting of hallmarks may offer promising therapeutic strategies.

Now online! Hallmarks of cancer—Then and now, and beyond

A global synthesis of yeast in microbiomes Yeasts are widespread members of microbial communities across terrestrial, aquatic, and host-associated environments, yet they remain underrepresented in microbiome studies due to low abundance and me...

here is our first contribution of yeast in microbiomes led by Jason Tsai group[ with contributions from Alberto and Nelly: www.biorxiv.org/content/10.6...
more to come

Launch of new Canada Impact+ Research Training Awards As announced in Budget 2025 -

Canada is launching a new funding program for PhD students and postdoctoral scientists.

Reach out to me if you are interested in studying gene regulation, RNA splicing and/or cancer immunotherapy using computational and/or experimental approaches.

#PhD #Postdoc

❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC).
No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...

Checkout the latest preprint from the lab - single-cell CIN signatures unlocked! Ongoing HRD improves PARPi sensitivity detection and ongoing NHEJ associates with subclonal diversification in TNBC

blog.addgene.org A Tour of Addgene's Most Popular Pooled Libraries

Thank the @johndoench.bsky.social and Root labs for depositing these deliciously named libraries, and check out our blog post for more:

Congratulations Ben!

Very excited to co-chair the 2026 Forbeck Forum on Evolution and Modeling of Cancer Genetic Networks and Cell States with @goyallab.bsky.social | Great line-up of speakers, intimate setting and thorough discussions!

www.forbeckforums.org/forums/evolu...

2026 #Yeast #Genetics Meeting is 13–17 June 2026 in Pacific Grove CA. Conference website has invited speakers, abstract submission topics, preliminary schedule, etc. Bookmark the site as additional updates will be published as they become available. #YEAST26

genetics-gsa.org/yeast-2026/

Please 🔁! #MASSIV will be held in Vancouver from January 19-22, 2026. 4-day meeting on #synbio x #tissueengineering.

Some trainee-focused events. >50 talks (10 from abstracts), posters, panel & publishing insights sessions.

www.massivconference.com

Abstract deadline: Nov 14

Canada Research Chair Tier II in Applied Synthetic Biology | Faculty of Arts and Science - Concordia University The Department of Biology in the Faculty of Arts and Science at Concordia University invites applications for a tenure track faculty position and Tier II Canada Research Chair (CRC) in Applied Synthet...

Our department is looking for a Canada Research Chair Tier 2 in Applied Synthetic Biology candidate! Deadline to apply is Dec 5, 2025. Please, repost. www.concordia.ca/jobs/artsci/...

Please RP! A 4-day synbio and tissue engineering conference #MASSIV to transform biology and medicine together.

Couldn't list all amazing speakers, so please check out this 👉https://www.massivconference.com/

Poster due is Nov 7, but will be extended.

With @stemcellnetwork.ca and JST.

Excited to share my first first-author preprint!
This work would not have been possible without the support and guidance of my supervisor Dr. Elena Kuzmin, as well as my lab mates (past and present) and our collaborators.

with a great team of collaborators @traver.bsky.social @guilbourque.bsky.social

4️⃣ Why are we excited about this is because this expands our understanding of how chromosome arm deletions are buffered in triple negative breast cancer which should enable us to develop targeted therapies.

3️⃣ Functional assays revealed that chr4p loss is associated with disrupted mitochondrial respiratory function and reduced glycolytic capacity, suggesting metabolic rewiring. Increased reactive oxygen species and lipid peroxidation compromised antioxidant defense mechanisms.

2️⃣ We analyzed DepMap pooled genome-wide CRISPRCas9 screens and identified complex genetic interactions specific to chr4p deletion in basal breast cancer cell models.

1️⃣ We used differential gene expression analysis of patient derived xenografts and cancer cell models to show that chr4p loss is associated with changes in cellular energetics.

Excited to share our preprint on the “Integrated Metabolic Complex Genetic Interaction Network of Chromosome 4p Loss in Basal Breast Cancer” led by @lynnkaram.bsky.social! www.biorxiv.org/content/10.1...

Thank you for highlight GSA!

In #G3journal, @elena-kuzmin.bsky.social et al. present PARPAL database, a valuable resource for #yeast researchers to understand the retention and evolution of paralogs. A phenomics screen further shows how proteins respond to paralog deletion by localization & abundance changes. buff.ly/oM97WyH

Our manuscript on the PARPAL database is out in G3! We share our phenomics screen on how proteins respond to their paralog deletion by localization & abundance changes and integrate other datasets with collab @guilbourque.bsky.social @leopoldparts.bsky.social doi.org/10.1093/g3jo...

Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens - Genome Biology Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CR...

At long last, Rosalind's paper on comparing methods for paralog synthetic lethality is online:

genomebiology.biomedcentral.com/articles/10....

8️⃣ Why are we excited about this is because this is the first systematic investigation of relocalization changes of paralogs and provides insight into their retention in evolution

7️⃣ Finally, our findings are consistent with non-canonical protein isoform abundance as a mechanism for paralog compensation

6️⃣ Redistributed proteins were encoded by functionally redundant paralogs and showed genetic and protein interactions in the subcellular compartments of their paralogs