Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM's Avatar

Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM

@agingdoc

Longevity medicine best practices | healthspan | precision medicine | geroscience | bio/acc | consulting @ agingdoc.com Connect: http://linkedin.com/in/agingdoc

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Latest posts by Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM @agingdoc

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Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice This study shows that oxidative changes in oocytes from aged female mice lead to lipid droplet accumulation and altered energy and retinoid metabolism. These changes persist in embryonic organs, trig....

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice

onlinelibrary.wiley.com/doi/10.1111/...

10.03.2026 00:07 👍 0 🔁 0 💬 0 📌 0
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Frontiers | Impact of exercise-induced DNA damage repair on age-related muscle weakness and sarcopenia Sarcopenia, the progressive and generalized loss of skeletal muscle mass, strength, and function with aging, poses a significant public health challenge. A k...

Impact of exercise-induced DNA damage repair on age-related muscle weakness and sarcopenia

👉 “exercise-induced enhancement of DNA repair [contributes to] maintaining mitochondrial health, preserving muscle stem cell function, and combating cellular senescence”

www.frontiersin.org/journals/gen...

07.03.2026 01:10 👍 3 🔁 1 💬 0 📌 0
Bridging Ethics, Science, and Practical Longevity
Bridging Ethics, Science, and Practical Longevity YouTube video by Longevity.Technology

Is #geroscience and #longevity for everyone, or just for a few? Podcast on the ethics of it all, with @agingdoc.bsky.social and Carolyn Ringel: www.youtube.com/watch?v=Tedu...

10.02.2026 01:34 👍 2 🔁 1 💬 0 📌 0
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Boston's Longevity Obsession: What Works and What Doesn't We talked to doctors at Mass General, Brigham and Women's, and more.

Boston’s Longevity Obsession: What Works and What’s Expensive BS

We're becoming more & more obsessed with living forever—but not all the treatments are created equal. What works, what doesn’t and whether optimizing every aspect of your life is really worth it.
www.bostonmagazine.com/news/2026/01...

01.02.2026 21:20 👍 1 🔁 0 💬 0 📌 0
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How to Make Friends as an Adult

How to Make Friends as an Adult

A practical guide for expanding your circle, with advice from sociable people.

www.nytimes.com/article/how-... @nytstyle.bsky.social

01.02.2026 19:27 👍 2 🔁 1 💬 0 📌 0
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Glucagon-like peptide-1 medicines and cancer - Nature Cancer Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cell...

Glucagon-like peptide-1 medicines and cancer

www.nature.com/articles/s43...

23.01.2026 12:17 👍 6 🔁 5 💬 0 📌 0
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Senate advances bills rejecting Trump’s efforts to slash research funding The White House sought cuts of 40% or more at some agencies, but lawmakers from both parties are pushing to hold science spending relatively steady.

Senate advances bills rejecting Trump’s efforts to slash research funding 🧪

The White House requested cuts of 40% or more at some agencies. But lawmakers from both parties are pushing to hold science spending relatively steady.

www.highereddive.com/news/senate-...

20.01.2026 22:40 👍 11 🔁 2 💬 0 📌 0
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Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds Gamma irradiation, an industry-standard sterilization method for medicinal and recreational cannabis, does not fully eliminate toxic fungi or their chemical residues, a McGill University study has fou...

Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds

Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards

www.mcgill.ca/newsroom/cha...

15.01.2026 19:39 👍 7 🔁 2 💬 0 📌 0
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Targeted delivery of genome editors in vivo

🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺

www.nature.com/articles/s41...

13.01.2026 15:18 👍 3 🔁 2 💬 0 📌 0

👍⚕️

13.01.2026 15:16 👍 1 🔁 0 💬 0 📌 0

My friend Andrew Steele is building this:

The majority of poor health and deaths globally are caused by diseases that become common with age...

"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded

We exist to change that" 🧑‍⚕️⚕️

thelongevityinitiative.org

28.12.2025 18:07 👍 9 🔁 4 💬 1 📌 0
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This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”

💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻‍⚕️

t.co/hMdyfVk58W

23.12.2025 02:20 👍 3 🔁 1 💬 1 📌 0
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Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity

👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.

academic.oup.com/jcem/article...

06.12.2025 15:22 👍 5 🔁 2 💬 0 📌 0
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People often ask me the same question:

“What’s the single most promising anti-aging measure coming in the next decade?”

If you care about where longevity medicine is truly heading, this one’s worth a look.

🔗https://www.instagram.com/reel/DRni2qQgNTS

28.11.2025 23:20 👍 7 🔁 2 💬 1 📌 0
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Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM on X: "Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric" / X Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric

Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function

"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"

x.com/agingdoc1/st...

19.11.2025 00:41 👍 8 🔁 2 💬 0 📌 0
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My post from Founders Forum North America (NYC) 🗽

🔗 www.linkedin.com/posts/agingd... 🚀

09.11.2025 22:48 👍 5 🔁 2 💬 0 📌 0
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AI Learns to Design the Human Body’s Most Elusive Proteins - Neuroscience News A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human pro...

AI Learns to Design the Human Body’s Most Elusive Proteins

🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.

neurosciencenews.com/ai-protein-d...

07.10.2025 00:07 👍 6 🔁 3 💬 0 📌 0
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Human skin DNA fertilised to make embryo for first time US scientists testing the technique say it could help people overcome infertility and potentially allow same-sex couples to have a genetically related child.

Scientists make embryos from human skin DNA for first time

www.bbc.com/news/article...

30.09.2025 20:05 👍 9 🔁 3 💬 1 📌 0

This AI tool predicts your risk of 1,000 diseases — by looking at your medical records

Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat

nature.com/articles/d41...

@shamini.bsky.social 🧪

30.09.2025 11:28 👍 1 🔁 0 💬 0 📌 0
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Sex-specific longitudinal reversal of aging in old frail mice | Aging Aging | doi:10.18632/aging.206304. Cameron Kato, Jessica Zheng, Cindy Quang, Sophia Siopack, Joana Cruz, Zachery R. Robinson, Nicole Fong, Zhixin A. Zhang, Patrick Young, Michael J. Conboy, Irina M. C...

Sex-specific longitudinal reversal of aging in old frail mice

www.aging-us.com/article/2063...

28.08.2025 23:07 👍 8 🔁 1 💬 0 📌 0
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The evolution of cancer and ageing: a history of constraint - Nature Reviews Cancer In this Perspective, de Magalhães explores the evolutionary relationship between cancer and ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration ...

The evolution of cancer and ageing: a history of constraint

www.nature.com/articles/s41...

28.08.2025 23:02 👍 3 🔁 0 💬 0 📌 0

@erictopol.bsky.social is right — we haven’t rigorously validated gerotherapeutics in humans, and even if we did, we’d need to show they also compress morbidity.

Some source for optimism: for some animal models, better healthspan can track increased longevity.

pmc.ncbi.nlm.nih.gov/articles/PMC...

28.08.2025 22:45 👍 1 🔁 0 💬 0 📌 0
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We’re thrilled to welcome David Barzilai MD PhD MBA MS DipABLM—an internationally acclaimed expert in longevity, CEO of Healthspan Coaching LLC, and a founding faculty member and Trustee of the… | Rev... We’re thrilled to welcome David Barzilai MD PhD MBA MS DipABLM—an internationally acclaimed expert in longevity, CEO of Healthspan Coaching LLC, and a founding faculty member and Trustee of the Geneva...

www.linkedin.com/feed/update/...

07.08.2025 19:01 👍 3 🔁 1 💬 0 📌 0
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Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds

Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds

A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯

www.nytimes.com/2025/08/04/s...

05.08.2025 13:21 👍 1 🔁 1 💬 0 📌 0

See you there!

02.08.2025 16:05 👍 1 🔁 0 💬 0 📌 0

👍

You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?

Keep up the great work Laura!

02.08.2025 11:02 👍 1 🔁 0 💬 1 📌 0
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Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds

Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds

The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…

www.nytimes.com/2025/07/28/h...

02.08.2025 10:59 👍 4 🔁 1 💬 0 📌 0
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DNA Methylation Ageing Atlas Across 17 Human Tissues

👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”

@nireynon.bsky.social and coauthors

www.biorxiv.org/content/10.1...

28.07.2025 21:01 👍 5 🔁 3 💬 1 📌 0
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Frontiers | Editorial: Resilience in aging In this editorial, we discuss contributions to the research topic of Resilience in Aging. Resilience refers to the capacity to recover from stress and restor...

Editorial: Resilience in aging

@drlaurahaynes.bsky.social and coauthors

www.frontiersin.org/journals/agi...

28.07.2025 20:52 👍 5 🔁 1 💬 1 📌 1
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AlphaGo Moment for Model Architecture Discovery

👉“ASI-Arch is presented, the first demonstration of Artificial Superintelligence for AI research (ASI4AI) in the critical domain of neural architecture discovery, with the first empirical scaling law for scientific discovery itself..“

t.co/ljJ1fXsslE

28.07.2025 17:06 👍 1 🔁 0 💬 0 📌 1