NEJM.org

A visual representation of the FINE-ONE trial, which assessed the efficacy and safety of finerenone among patients with CKD and type 1 diabetes.

Finerenone improves kidney and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes, but its efficacy in type 1 diabetes is unknown. The FINE-ONE trial involving patients with CKD and type 1 diabetes is summarized in a new Quick Take video. nej.md/3PcIJWt

15th European Lupus Meeting Original Article | MAR 6, 2026 | NEJM.org Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus Figure 1A. Time to First BILAG Flare.

In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks. Full phase 3 ALLEGORY trial results: nej.md/4smEuWW

#MedSky

Hear more from Dr. Hill in the latest episode of the Not Otherwise Specified podcast hosted by NEJM National Correspondent Lisa Rosenbaum, MD: nej.md/4cLCRgG

Listen to past episodes and subscribe to the podcast: nej.md/NOS

Emily Hill, DO, who recently finished her family medicine residency, discusses a case that turned out to be one of her most gratifying she had as a resident.

#MedSky

An illustrated diagram of representative acute, subacute, and late effects of radiotherapy and their management.

A new review summarizes advances in radiotherapy that reduce injury to normal tissue, including improvements in the precision of imaging and delivery, and outlines strategies to prevent and manage treatment-related side effects. Read the full review: nej.md/4cjpcxk

#MedSky #Oncology

Original Article | MAR 5, 2026 Neoadjuvant GOLP in Resectable High-Risk Intrahepatic Cholangiocarcinoma (ZSAB-neoGOLP) Figure 2A. Event-free Survival.

Neoadjuvant gemcitabine–oxaliplatin, lenvatinib, and anti–PD-1 antibody led to longer event-free survival than surgery alone in resectable high-risk intrahepatic cholangiocarcinoma, with mainly low-grade adverse events. Full phase 2–3 ZSAB-neoGOLP trial results: nej.md/4sm3X2C

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Zorevunersen in Children with Dravet Syndrome nej.md/4l97OxE

Neoadjuvant GOLP in Intrahepatic Cholangiocarcinoma (phase 2–3 ZSAB-neoGOLP trial) nej.md/4sm3X2C

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Images and descriptions of what's new on NEJM.org this week  

New in the March 5, 2026, issue of NEJM:

Finerenone in Type 1 Diabetes and CKD (phase 3 FINE-ONE trial) nej.md/4rTPAmu

Nonculprit-Lesion PCI in Myocardial Infarction (iMODERN trial) nej.md/3Llf6QU

#MedSky

Science behind the Study Toward a Disease-Modifying Therapy for Dravet Syndrome An illustrated diagram of targeting a “poison” (nonproductive) exon to treat Dravet syndrome.

Gemma L. Carvill, PhD, and Heather C. Mefford, MD, PhD, describe the scientific foundations of a study of zorevunersen, an antisense oligonucleotide, for the treatment of a severe epilepsy syndrome. Learn more: nej.md/3OKrEDq

@hcmefford.bsky.social #MedSky #NeuroSky

Science behind the Study: Toward a Disease-Modifying Therapy for Dravet Syndrome nej.md/3OKrEDq

Original Article | MAR 5, 2026 Zorevunersen in Children and Adolescents with Dravet Syndrome Figure 1B. Change in Seizure Frequency in MONARCH–ADMIRAL Multiple-Ascending-Dose Cohorts According to Zorevunersen Dose

This report describes the effects of zorevunersen, an antisense oligonucleotide designed to up-regulate NaV1.1 sodium channels, in patients with Dravet syndrome, which is a severe developmental and epileptic encephalopathy. Read the full report: nej.md/4l97OxE

#MedSky #NeuroSky

Editorial: Finerenone for Diabetic Kidney Disease in Type 1 Diabetes — A Fine Answer? nej.md/4rHKN7B

Original Article | MAR 11, 2026 Finerenone in Type 1 Diabetes and Chronic Kidney Disease (FINE-ONE) Figure 1. Change in the Urinary Albumin-to-Creatinine Ratio.

In adults with type 1 diabetes and chronic kidney disease with albuminuria, the decrease in the urinary albumin-to-creatinine ratio was significantly greater with finerenone than with placebo. Full phase 3 FINE-ONE trial results: nej.md/4rTPAmu

#MedSky #EndoSky #Nephrology

Mpox continues to spread in many communities. Tecovirimat has activity against orthopoxviruses in vitro. In a phase 3 trial involving patients with acute mpox, tecovirimat showed no evidence of clinical activity.

Full STOMP/A5418 trial results and Research Summary: nej.md/4rdlMA9

#MedSky #IDSky

Colorized image of influenza virus

New Public Health Alerts paper in NEJM Evidence & CIDRAP shows that the current flu vaccine produces antibodies that efficiently recognize subclade K in almost 40% of people.

Read full alert: ow.ly/xWeF50YoTmP

Key Points from the Review Article "Group B Streptococcal Disease"

A new review by Karen M. Puopolo, MD, PhD, describes the microbiologic and epidemiologic features, pathogenesis, treatment, and prevention of group B streptococcal disease. Read the full review: nej.md/4aJJ6Pv

#MedSky #IDSky #Neonatology

Can coffee and tea prevent dementia?

NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, shares his take on an observational study on whether caffeinated #coffee and tea consumption could reduce the risk of dementia. Full context and comment: jwat.ch/4aMBZpt

#caffeine

Figure 1. Human Antibody Recognition of H3N2 Subclade K Virus.

𝐍𝐨𝐰 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐢𝐧 𝑵𝑬𝑱𝑴 𝑬𝒗𝒊𝒅𝒆𝒏𝒄𝒆!

A new Public Health Alerts report, published in partnership with @cidrap.bsky.social: Antibodies Elicited by the 2025–2026 Influenza Vaccine eviden.cc/47fN8Oz

#MedSky #IDSky

The New England Journal of Medicine Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges A Research Summary based on Rana AI et al. | 10.1056/NEJMoa2508228 | Published on February 18, 2026 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In persons with #HIV and barriers to adhering to antiretroviral therapy, a long-acting injectable treatment (monthly cabotegravir plus rilpivirine) resulted in better virologic control than standard oral ART. Full LATITUDE trial results and Research Summary: nej.md/4qFyjMm

#MedSky #IDSky

To learn more about this term, read the editorial “Restoring Function to a Variant of p53 in Solid Tumors” by Xin Lu, PhD: nej.md/3N0pQW8

Explore more terms: nej.md/glossary

Visual representation of "TP53"

𝐓𝐏𝟓𝟑 is the gene that encodes the tumor-suppressor protein p53.

Full definition of this NEJM Illustrated Glossary term: nej.md/4cINZuK

#ScienceSky

Requiring Annual N95 Mask Fit Testing Is a Waste of Time and Money Is it time to replace annual N95 mask fit testing with a less expensive, evidence-based policy?

In this @nejm.org Voices post, I take on one of the more annoying and pointless rituals of hospital work -- the annual N95 fit test.
As one of the respected infection control specialists told me, it's not their fault. And I totally believe them. #idsky #medsky
voices.nejm.org/doi/full/10....

Explore the full March 2026 issue: nej.md/40e5VG6

"In this large, linked electronic medical record–Medicare cohort study, artificial intelligence–driven imminent hospitalization prediction model–directed interventions were associated with an 8% reduction in the odds of 7-day hospitalization.” Article | Feb 18, 2026 AI-Driven Interventions for Imminent Hospital Admissions in Patients with End-Stage Kidney Disease: A Medicare and EMR-Based Analysis NEJM Catalyst Innovations in Care Delivery

New in NEJM Catalyst: Real-time case review and clinical intervention, as prompted by the analysis of imminent hospitalization prediction models, are associated with lower odds of hospitalization for hemodialysis patients at risk of fluid overload or infection. Learn more: nej.md/4aEGToC

Original Article | Feb 26, 2026 Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality W. Ganglberger and Others A visual representation of the study.

This study demonstrates that an end-to-end, multitask deep learning framework applied to overnight sleep electroencephalography can derive a latent representation of brain health distilled into a single, interpretable score. Full study results: nejm.ai/4sbnrqw

#AI #MedSky #MLSky

Group B streptococcal infection mostly affects newborns, infants, pregnant persons, and older adults. Perinatal prevention is successful but contributes to antibiotic exposure. Multivalent glycoconjugate vaccines are in development. Read the full review: nej.md/4aJJ6Pv

#MedSky #IDSky #Neonatology

The New England Journal of Medicine Trastuzumab Deruxtecan in Residual HER2-Positive Early Breast Cancer A Research Summary based on Loibl S et al. | 10.1056/NEJMoa2514661 | Published on December 10, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In patients with HER2-positive early breast cancer and residual disease after neoadjuvant therapy, trastuzumab deruxtecan improved invasive disease–free survival but carried a risk of interstitial lung disease. Full phase 3 DESTINY-Breast05 trial results and Research Summary: nej.md/4an3Az2

A visual representation of the STOMP/A5418 trial, which assessed the efficacy and safety of tecovirimat in patients with mpox.

Effective therapeutics are needed for mpox. Tecovirimat is FDA-approved to treat smallpox, but its efficacy and safety in patients with mpox have been unclear. Research findings from the Phase 3 STOMP/A5418 trial are summarized in a new Quick Take video. nej.md/4chKFXz

#MedSky #IDSky

Images in Clinical Medicine Subacute Sclerosing Panencephalitis after Measles Infection Panels A and B: MRI of the head showing edema and restricted diffusion in the frontal lobes that involved the cortical ribbon and white matter and extended into the corpus callosum.

A 7-year-old boy was brought to a hospital with a 3-month history of cognitive deterioration and seizures. He had contracted measles at 7 months of age while living in an area where the infection is endemic. Read the full case details: nej.md/4qY4Ihk

#MedSky #NeuroSky #IDSky

Figure 1. Bacteria Cultured from Injured Ukrainian Service Members. Shown are bacteria cultured from the wounds of 127 injured Ukrainian service members, with percentages assigned to each bacterial family and to each genus within the Enterobacteriaceae family. Percentages may not total 100 because of rounding.

Battlefield injuries are often contaminated with potentially infecting microbes. In this study, swabs obtained in the field after injury were profiled. Microbes and potential antimicrobial-resistance genes were characterized. Full study results: nej.md/4l1hpqk

#MedSky #IDSky