@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
Tissue-specific I-Smad mechanisms revealed by structureβfunction analysis in Drosophila @scsu.bsky.social @mikkys.bsky.social
www.life-science-alliance.org/content/9/5/...
E-cadherin in the cytokinetic furrow reduces division fidelity. Formin-actin at the division zone limits its lateral mobility. π¬
@anups11.bsky.social
www.life-science-alliance.org/content/9/5/...
No label-free methods report both the functional and physical state of single mitochondria. AFM imaging + nanoscale phenotyping enable single-mitochondrion analysis. @reviewcommons.org
www.life-science-alliance.org/content/9/5/...
Negative results can provide valuable insights about the natural world, but are often dismissed as unimportant and uninteresting. This Special Collection brings focus to these overlooked studies, with an editorial by Executive Editor Tim Fessenden: www.life-science-alliance.org/content/nega...
Spinocerebellar ataxia type 8, a neurological disease with no effective treatment, is caused by a CAGβ’CTG expansion. In SCA8 mice, metformin reduces RAN proteins and neuroinflammation, improves behavior, and partially corrects splicing.
www.life-science-alliance.org/content/9/5/...
Why do some cells respond differently to the same signaling molecule? This study reveals that inhibitory Smads use tissue-specific mechanisms-DNA binding in wings, but multiple strategies in neurons.
@scsu.bsky.social @mikkys.bsky.social
www.life-science-alliance.org/content/9/5/...
New study uncovers a previously unrecognized signaling pathway in which Rnd3 controls the metastatic potential of lung cancer cells. By dissecting this mechanism, the authors highlight new opportunities to therapeutically target metastatic disease.
www.life-science-alliance.org/content/9/5/...
In our March issue, discover deep connections between neurodegeneration and circadian gene expression, learn new modulators and outputs of Hippo signaling in development, and read a fresh perspective on maladaptive stress responses.
www.life-science-alliance.org/content/9/3
Negative results can provide valuable insights about the natural world, but are often dismissed as unimportant and uninteresting. This Special Collection brings focus to these overlooked studies, with an editorial by Executive Editor Tim Fessenden: www.life-science-alliance.org/content/nega...
Take a look at this recently published paper in LSA π
Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction
www.life-science-alliance.org/content/9/4/...
π Take a look at a recently published paper in LSA:
Natural variations in maternal behavior shape anxiety and hippocampal neurogenesis in offspring
π www.life-science-alliance.org/content/9/5/...
The study shows that tuberculosis-driven glycolysis in macrophages promotes tunneling nanotube formation, thereby enhancing HIV-1 spread, highlighting metabolism as a target to limit viral dissemination.
www.life-science-alliance.org/content/9/5/...
Cx32 maintains quiescence and blocks migration/TGFΞ² & mesenchymal changes in human urothelium, highlighting luminal MIBC biology @biologyatyork.bsky.social @ybri-uoy.bsky.social @jennybaker.bsky.social @drsimonbaker.bsky.social @asmasonomics.bsky.social www.life-science-alliance.org/content/9/5/...
Here, the authors identify a novel signaling pathway in which Rnd3 regulates the metastatic potential of lung cancer cells. Understanding this pathway could be leveraged to target metastatic disease.
www.life-science-alliance.org/content/9/5/...
In this study, the authors show that treatment with acetyl-carnitine can ameliorate learning and memory defects and hyperactivity in a mouse model of the cognitive disorder, Arboleda-Tham syndrome.
www.life-science-alliance.org/content/9/5/...
Our new paper is out in @lsajournal.org
We explored how glycolysis inhibition in tuberculosis-infected macrophages can reduce HIV-1 spread.
π Read it here: doi.org/10.26508/lsa...
Huge thanks to @Zoi Vahlas, @lucianabalboa.bsky.social, @oneyrolles.bsky.social & @chrisverollet.bsky.social
What happens when you combine all that is known about a large protein with almost 2000 residues with Alphafold2, new experiments, and in-depth structural bioinformatics? www.life-science-alliance.org/content/9/4/...
Subtle variations in non-traumatic early life experience are associated with long-lasting trajectories in pups' brain development and behavior.
www.life-science-alliance.org/content/9/5/...
TB boosts macrophage glycolysis, triggering tunneling nanotubes that accelerate HIV-1 spread. Blocking HIF-1Ξ±-dependent metabolism disrupts this process, highlighting new metabolic targets for TB/HIV co-infection.
www.life-science-alliance.org/content/9/5/...
Hinley et al.: Connexin 32 sustains urothelial quiescence and limits TGFΞ²-driven remodelling, revealing a luminal MIBC split.
@biologyatyork.bsky.social @ybri-uoy.bsky.social @jennybaker.bsky.social @drsimonbaker.bsky.social @asmasonomics.bsky.social
www.life-science-alliance.org/content/9/5/...
ATF2 enters the nucleus via importin-Ξ±/Ξ²1 using two basic clusters that bind major and minor sites of importin-Ξ±1. Structural and cell data reveal redundancy, CRM1 export, and c-Jun-assisted co-import.
www.life-science-alliance.org/content/9/4/...
The study characterizes a full cytohesin-2 knockout, highlighting its crucial role in perinatal development and its importance in maintaining Golgi structure and function. @limes-bonn.bsky.social @wkolanus.bsky.social
www.life-science-alliance.org/content/9/5/...
In mice lacking one copy of the Kat6a gene, a mouse model of the Arboleda-Tham cognitive impairment syndrome, the authors show that learning and memory defects can be ameliorated by treatment with acetyl-carnitine.
www.life-science-alliance.org/content/9/5/...
π A recent study in LSA reveals that increased Piezo levels lead to both structural and functional changes in Drosophila garland nephrocytes.
#Research #Drosophila
www.life-science-alliance.org/content/9/4/...
Genomic uracil patterns and APOBEC3 activation create unique cellular responses to thymidylate synthase inhibitors. This links uracil metabolism to mutations and drug resistance in colon cancer cells.
#CancerResearch #DrugResistance
www.life-science-alliance.org/content/9/4/...
Research uncovers how cells adjust to mechanical stress through autophagy-driven changes in focal adhesion and enhanced mitochondrial activity.
#CellBiology #ResearchInsights
www.life-science-alliance.org/content/9/4/...
New Research article in LSA:
The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress
#Notch1 #CellBiology
@ctbatucsf.bsky.social
Take a look: π
www.life-science-alliance.org/content/9/4/...
Check out this recently published paper in LSA:
NCOA4 initiates ferritinophagy by avidly binding GATE16 using two short linear interaction motifs www.life-science-alliance.org/content/9/4/...
π ATF2 nuclear import mechanism revealed π§¬
π www.life-science-alliance.org/content/9/4/...
#ATF2 #CellBiology #Science
Weβre pleased to highlight a recent study published with us:
TBK1 activity regulates the directionality of axonal transport of signalling endosomes.
#Neuroscience #AxonalTransport #Research
Read the full paper π www.life-science-alliance.org/content/9/4/...
