Our last paper is out at IAI @asm.org . With @cbuch.bsky.social, at @pasteur.fr . Congrats Francisco & Paula !
Mitochondrial Complex I emerges as a common energetic checkpoint distinguishing virulent from secretion-deficient bacteria during Legionella and Salmonella infection of human macrophages.
Unrooted phylogeny indicating the major clades of Mycobacterium bovis found in Ireland.
The genomic diversity and spatial patterns of Mycobacterium bovis in Ireland revealed by whole genome sequencing rdcu.be/e50zT
New tools for Streptococcal cell biology! congrats to Johann Mignolet and Virginie Libante! doi.org/10.1093/fems...
Let's celebrate excellence together as we recognize the winners of the 2025 FEMS Journals Article Awards. These awards recognize the outstanding contributions of researchers who have pushed the boundaries of knowledge in the field of microbiology: buff.ly/OZ2eTKA
New research from @pasteur.fr reveals how 𝐿𝑒𝑔𝑖𝑜𝑛𝑒𝑙𝑙𝑎 uses LpDot1 to methylate SFPQ, disrupting paraspeckles & rewiring host splicing, dampening immune genes like NF-κB2 & CD45 for survival.
✍️ @cbuch.bsky.social, @mrolando.bsky.social & coll.
📖 Read the preprint: shorturl.at/kFh8z
#MicroSky
Bacterial targeting of host paraspeckles uncovers a new SFPQ-based regulation https://www.biorxiv.org/content/10.64898/2026.01.11.698932v1
In Conversation "science knows no country": Professor Sir Stewart Cole and Professor Dame Angela McLean. ©Pasteur Foundation UK
🇬🇧🇫🇷 "By working together we can overcome challenges faster"
Pasteur Foundation UK launched the formal @institutpasteur x @ox.ac.uk partnership in London.
From climate to AMR, cross-border collaboration is science's engine.
↘️ www.pasteurfoundation.uk/pasteur-oxfo...
De-DUFing the DUFs 🧩 @franznarberhaus.bsky.social lab uncovers how small DUF1127 proteins regulate #phosphate uptake by binding the sensor kinase PhoR. Their conserved role from Agrobacterium to E. coli highlights how even small DUFs can shape bacterial physiology 🦠
buff.ly/jJd9Eho
Thus, single-cell metabolic dynamics can forecast infection outcomes. In the spirit of @stephenwolfram.bsky.social's ideas, bacterial infection exhibits pockets of computational reducibility at the single-cell scale. Might this point to new ways to predict infection progression?
So we trained an explainable Machine Learning model using Δψm + mROS dynamics, and the AI model predicted which infected cell will support replication with 83% accuracy before bacterial replication begins
What make these permissive macrophages different? Before bacteria replicate, macrophages that will permit bacterial growth already show sustained mitochondrial membrane potential (Δψm) and higher mitochondrial ROS (mROS). These are early mitochondrial signals of permissive cells!
We tracked thousands of living primary human macrophages during infection with Legionella pneumophila, using high-throughput live imaging + our BATLI backtracking software. Legionella only replicates in ~20% infected primary macrophages!
www.nature.com/articles/s41...
New paper finally out on @natcomms.nature.com! Led by first author Maria Dramé with the collaboration of Francisco Garcia, @cbuch.bsky.social and @jytinevez.bsky.social at @pasteur.fr. Early mitochondrial signals in single human macrophages predict later Legionella replication. Link + details👇🧵
Some #Pseudomonas aeruginosa strains naturally lack the major virulence system T3SS. 🦠 @inaattree.bsky.social & @cbuch.bsky.social labs reveal that avirulent isolates still produce valuable metabolites (e.g. rhamnolipids, elastase, pyoverdine)—making them promising for #biotech use.
buff.ly/JST7ZR1
Save the date! The @pasteur.fr Pasteur course on image analysis is announced:
It will happen from the 1st of June to the 5th 2026.
This year there will be only one track: the Early Career Investigator track (beginners). 👇
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
New publication | Science Advances www.science.org/doi/10.1126/...
Die Infektionsforscherinnen Anja Lührmann, Sandra Reuter, Gabriele Pradel und Bärbel Stecher stehen stolz vor den Werbebannern von Infect-Net, Verband Deutscher Infektionsforscherinnen.
🔎 Find us at the 77th #DGHM Meeting in #Jena! Gabriele Pradel, Anja Lührmann, Sandra Reuter, Bärbel Stecher and others are happy to tell you more about our German network for women in infection research! 💜
👩🔬@gabrielepradel.bsky.social @sandrareuter.bsky.social @baerboletta.bsky.social
Phages are promising against antibiotic-resistant bacteria—but resistance can emerge. 🦠 New work from @baerboletta.bsky.social lab shows E. coli can resist phages in the lab, but in the gut that resistance comes at a cost: context is crucial for #PhageTherapy success.
buff.ly/NLOjnE2
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
🇪🇺 Smooth publishing experience with #microLife, the new @femsjournals.bsky.social journal of the European Academy for Microbiology.
🙏 @erc.europa.eu, F.R.S-FNRS & WEL-RI for support
4/4
🚨New paper out! #MicroSky
Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival.
We expanded its genetic toolbox:
🧬promoters to fine-tune expression
🧬IPTG-inducible system
🧬CRISPRi for rapid knockdown
bit.ly/46GUn2c
1/4
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
New preprint in the lab! How the mitochondrial ETC works during infection of human macrophages with #Legionella or #Salmonella? Spoiler: there are some similarities and also pathogen-specific differences. Work led by Francisco Garcia and Paula Martínez, with @cbuch.bsky.social at @pasteur.fr
🔬 We’re past the midpoint of the year; perfect time to look back at what’s been discovered so far. From how Salmonella slows its escape from immune cells to the microbes thriving in oil reservoirs, these are the most-read #microLife papers of 2025 so far: buff.ly/TfhOvEc
I was very honored to receive on of the Poster prizes at FEMS MICRO 2025 in Milan a few weeks back. It was such a great conference, heard so many interesting and stimulating talks & poster discussions.
Avirulent Pseudomonas aeruginosa T3SS-negative strains belonging to Clade 5 produce variable quantities of secondary metabolites
@femsjournals.bsky.social #microLife from @inaattree.bsky.social
with @cbuch.bsky.social
academic.oup.com/microlife/ad...
This 👇
Michael Patnode with Rachel Washburn, Jessica Aycock, and Mason Clark, winners of GRC MAST poster awards from Cell Press and FEMS
Congratulations to 2025 GRC Microbial Adhesion and Signal Transduction Poster Award Winners!! 🎆🥂🙌 Thank you @cp-cell.bsky.social and @femsmicro.org for sponsoring!
From,
Your secret judges 🤫
