Journal of the American Chemical Society (JACS)

Supplementary Cover of JACS Vol 148/Issue 8 Week Commencing March 2, 2026

"Unlabeled NMR Approach with Site-Specific Methyl Assignments for Structural Evaluation of the IgG1 Fc Region" has been featured in the latest issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 8 Week Commencing March 2, 2026

"The Effect of Allosteric Conformational Regulation on the Crystal Packing of Aromatic Amide Metallomacrocycles via Ligand-Modulated Remote Intramolecular Hydrogen Bonds" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 8 Week Commencing March 2, 2026

"Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly" has been featured in this week's issue of #JACS.

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Front Cover of JACS Vol 148/Issue 8 Week Commencing March 2, 2026

“Electride-Stabilized Iridium Nanoparticles with Subsurface Oxygen Confinement for Oxygen Evolution Electrocatalysis" has appeared on the front cover of this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 7 Week Commencing February 23, 2026

"Thermodynamic Controlled Atomic Pairing: A Potential Window Strategy for Precise Synthesis of Dual-Atom Electrocatalysts via Sequential Electrodeposition" has been featured in the latest issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 7 Week Commencing February 23, 2026

"Accelerated Defluorination Kinetics for an Ultrathin Solid–Electrolyte Interphase in Durable Lithium Metal Batteries" has been featured in the latest issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 7 Week Commencing February 23, 2026

"Structural Insights into Three Bifunctional Sesterterpene Synthases and Product Profile Investigation by Domain Swapping and Active Site Mutation" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 7 Week Commencing February 23, 2026

"Nanoparticle-Single-Atom Tandem Catalyst within a Metal–Organic Framework for Efficient Ethylene Electrosynthesis" has been featured in this week's issue of #JACS.

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Front Cover of JACS Vol 148/Issue 7 Week Commencing February 23, 2026

“Thiol-Regulated Rhodium Nanocatalyst for Electrochemical Reductive Perdeuteration of Alkenes" has appeared on the front cover of this week's issue of #JACS.

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Announcing the upcoming ACS150 JACS Symposium Series: IACS Kolkata! 📍 Kolkata, India 📅 1 July

Upcoming: ACS150 JACS Symposium Series: IACS Kolkata

📍 Kolkata, India
📅 1 July

Celebrating 150 years of ACS and chemical discovery with an exciting full day of cutting-edge science in Elevating the Future of Macromolecular Materials. 

Space is limited, apply to attend today: buff.ly/3lcYqGN

Supplementary Cover of JACS Vol 148/Issue 6 Week Commencing February 16, 2026

"Redox-Switchable Halogen Bonding in Haloanthracene Mediators Enables Efficient Electrocatalytic C–N Coupling" has been featured in the latest issue of #JACS.

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Borenium Ions as Functional Materials Borenium ions are tricoordinate boron cations of the type [LBR2]+, where L is a donor ligand. While the inherently reactive nature of these Lewis acidic species has been harnessed to advance bond acti...

Check out Nathan's article in @jacs.acspublications.org on luminescent and stimuli-responsive borenium ion materials! #maingroup pubs.acs.org/doi/10.1021/...

Supplementary Cover of JACS Vol 148/Issue 6 Week Commencing February 16, 2026

"Local Symmetry Breaking Induced Superionic Conductivity in Argyrodites" has been featured in the latest issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 6 Week Commencing February 16, 2026

"Amino Acid Residue-Driven Nanoparticle Targeting of Protein Cavities: Surface Chemistry Dictates Binding Specificity beyond Size Complementarity" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 6 Week Commencing February 16, 2026

"A Highly Selective Cobalt Catalyst for Primary Amine Synthesis from Carboxylic Acids, Esters, and Vegetable Oils" has been featured in this week's issue of #JACS.

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Just out in @jacs.acspublications.org:
"Interplay of Redox Non-Innocence and Symmetry Breaking in a 4d Coordination Framework"

🧪We’ve made Mo(pyz)₂I₂, the 4d cousin of the Cr(pyz)₂X₂ family—with redox-active ligands, symmetry breaking, semiconducting transport, and strong magnetic interactions.
🔗👇

Microbial dl-Peptidases Enable Predator Defense and Facilitate Structure Elucidation of Complex Natural Products Peptidases are indispensable tools in biotechnology and chemical biology. However, the enzyme repertoire for the selective hydrolysis of dl-amide bonds in peptides is small. Here, we describe novel dl-peptidases that mediate complex microbial interactions. These enzymes, Lip3 and Lip7, convert lipopeptides into potent amoebicidal agents via selective dl-peptide bond cleavage. Using structural analyses and mutagenesis, we identified an unusual Ser–Lys–Lys–Tyr catalytic tetrad required for dl-specificity. Despite their high structural similarity, both enzymes show distinct substrate preferences: Lip3 acts primarily as a carboxypeptidase, removing a single C-terminal residue, while Lip7 excises a tripeptide. Although their substrate scopes are broad, they are highly specific with regard to their respective cutting sites. These features make these dl-peptidases powerful tools for elucidating the structure of complex peptide-based natural products, including tensin and WLIP. Overall, this work elucidates the molecular mechanisms of cooperative microbial defense and provides a new enzymatic toolbox for biocatalysis and natural product discovery.

Great paper by the groups of Pierre Stallforth, @hellmichgroup.bsky.social and @mlakemeyer.bsky.social of @uni-jena.de in @jacs.acspublications.org . Microbial DL-peptidases with an important role in predator defense.
pubs.acs.org/doi/10.1021/...
#ChemSky #ChemBio #Biochemistry #Bacteria #Microbes

Investigating Halogen Bonds as Pairing Force in an Artificial DNA Base Pair The past decades have seen significant expansion of the nucleic acid space with the development of modified artificial base pairs based on natural nucleic acid analogues and even entirely new designed base pairs. This expansion has led to tremendous potential for applications such as site-specific labeling and structural investigations. However, natural nucleic acids rely strongly on hydrogen bonding as the attraction force, which has driven the development of artificial base pairs that adapt this mechanism. To achieve orthogonality with natural bases, unnatural base pairs with alternative attraction forces, such as hydrophobic interactions, have been developed which however can perturb duplex structures. Our work introduces a completely newly designed artificial base pair that leverages halogen bonding (R–Hal···) as a directional hydrogen bonding-like interaction. We report computational studies that led to the development of this novel unnatural base pair and its synthesis. Our results demonstrate the successful acceptance of a bulky iodinated nucleoside triphosphate by KlenTaq DNA polymerase, enabling the selective enzymatic synthesis of a DNA strand containing the dIIPO–doIPP base pair. Our work presents the first demonstration of a novel base pair with halogen bonding potential that is enzymatically incorporated into DNA.

New paper in @jacs.acspublications.org 🎉:
A de novo designed unnatural base pair that exploits halogen bonding as pairing force in DNA for genetic alphabet expansion. 🧬 ⚗️
@unicologne.bsky.social
@chemunicologne.bsky.social
@breugstlab.bsky.social

pubs.acs.org/doi/abs/10.1...

C3-Symmetric Photoresponsive Chiral Dopants Based on Tribenzotriquinacene Doping cholesteric liquid crystals (CLCs) with photoresponsive chiral molecules is an effective strategy for devising responsive soft materials, as it allows for the phototuning of the noncovalent interactions in the CLCs, and hence, their helical pitch and optical properties. Here we describe the use of tribenzotriquinacene-based (TBTQ) hydrazone and azobenzene chiral dopants in the modulation of the helical pitch of the LC host, 5CB. The unique C3-symmetry of the TBTQ scaffold enhances the noncovalent interactions with the host and thus the chiral information transfer, resulting in helical twisting power (β) values as high as 147 μm–1. Notably, the TBTQ hydrazone exhibits an unusual deviation from trends observed so far in previous studies, resulting in larger β values for the Z isomer rather than the E one. Moreover, the overall β values for the hydrazone-based dopants are unexpectedly higher than those of the azobenzene dopants. These results indicate that the host/guest interactions are better when the photoswitchable chiral dopant is more rigid, as is the case with the H-bonded Z state of the hydrazone. The large β values and excellent miscibility of the hydrazone-based dopants in 5CB allowed us to design films that reflect visible structural color. The properties of the azobenzene-based dopants precluded their use in such applications. By codoping 5CB with hydrazone and azobenzene derivatives of opposite chirality, we demonstrated reversible handedness inversion upon photoswitching, providing a versatile soft material platform for reconfigurable photonic materials and colorimetric display technologies.

Latest @jacs.acspublications.org a collab with Mastalerz grp @uniheidelberg.bsky.social showing how C3-symmetric TBTQ core affects chiral induction in LCs. Hydrazone > azobenzene with this core. Mixing these two with opposite chirality allows handedness inversion bit.ly/4qAtvYE #openaccess #chemsky

Front Cover of JACS Vol 148/Issue 6 Week Commencing February 16, 2026

“Epitaxial Integration of Single-Crystalline 2D Bi2O2Se Semiconductor Film on Silicon " has appeared on the front cover of this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 5 Week Commencing February 9, 2026

"Stepwise Ligand-Exchange Strategy for the High-Yield Synthesis of Water-Soluble, Metal-Doped MAg24 Nanoclusters" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 5 Week Commencing February 9, 2026

"Microbial dl-Peptidases Enable Predator Defense and Facilitate Structure Elucidation of Complex Natural Products" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 5 Week Commencing February 9, 2026

"A Rational Design of Chiral Iron(III) Complexes for Photocatalytic Asymmetric Radical Cation (4 + 2) Cycloadditions and the Total Synthesis of (+)-Heitziamide A" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 5 Week Commencing February 9, 2026

"Complementary Adsorption within Metal–Organic Frameworks for Ethylene Upgrading from Refinery Dry Gas" has been featured in this week's issue of #JACS.

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Front Cover of JACS Vol 148/Issue 5 Week Commencing February 9, 2026

“Heterointerface-Enabled Anti-Reverse-Current Electrodes for Alkaline Water Electrolyzers at 1000 mA cm–2" has appeared on the front cover of this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 4 Week Commencing February 2, 2026

"Encapsulation of 211At(Ø)+ into a Nanoscale Covalent Organic Framework Prevents Deastatination In Vivo" has been featured in the latest issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 4 Week Commencing February 2, 2026

"Electrochemically Tuned Crystal Tectonics in Crack-Resistant Textured Oxide Cathode Films for Electrochemical Energy Storage" has been featured in the latest issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 4 Week Commencing February 2, 2026

"Chemical Synthesis of Native ADP-Ribosylated Oligonucleotides Enables Analysis of DNA ADP-Ribosylation Hydrolase Specificity" has been featured in this week's issue of #JACS.

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Supplementary Cover of JACS Vol 148/Issue 4 Week Commencing February 2, 2026

"Potent Racemic Antimicrobial Polypeptides Uncovered by a Stereochemical Series of Cationic d/l Backbones" has been featured in this week's issue of #JACS.

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Front Cover of JACS Vol 148/Issue 4 Week Commencing February 2, 2026

“Zeolite-Encapsulated Ir Single Atom Catalysts Toward Efficient and Stable Propane Dehydrogenation" has appeared on the front cover of this week's issue of #JACS.

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