Casey Schneider-Mizell's Avatar

Casey Schneider-Mizell

@csdashm.com

Assistant Investigator at Allen Institute for Brain Science. Formerly Janelia, Universität Zürich, and U Mich Physics. Building bottom-up insight into the brain from synaptic resolution connectomics and making computational tools to help you do that too.

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12.10.2024
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Latest posts by Casey Schneider-Mizell @csdashm.com

Airlines should be required to show you a big warning banner when you select flights on Daylight Savings transition days.

06.03.2026 18:45 👍 2 🔁 0 💬 0 📌 0

I’m sure there’s where my gourmand-ness started, exactly

06.03.2026 04:14 👍 1 🔁 0 💬 1 📌 0

Okay but what about Chef Boyardee Ravioli?

06.03.2026 03:43 👍 1 🔁 0 💬 1 📌 0

Consider this my plea to ping me if I know you and you're going to be there too!

04.03.2026 04:16 👍 0 🔁 0 💬 2 📌 0
Workshop – Synapses at Scale - COSYNE 2026

Looking forward to heading off to Cosyne next week, and excited to be part of a two day workshop about connectomics, with day one being about species comparison and day two about using data for constraining models. alleninstitute.github.io/connectomics...

04.03.2026 04:11 👍 7 🔁 1 💬 1 📌 0

Below is the response to my question. The funny part of his response is that my research needed a control arm. My study actually did have a control arm (about 80% of the sample never reported discrimination).

So the answer itself makes me even more confused.

26.02.2026 21:08 👍 82 🔁 36 💬 11 📌 13

In what world is it even helpful to treat this guy like he's not a vicious, churning, petty, malignant, Internet-rotted psychopath

27.02.2026 02:13 👍 108 🔁 26 💬 4 📌 4

This seems important when thinking about all of the people (especially academics) who stayed in Epstein's orbit. Not that all would agree in the details per se, but that they were not repulsed by deeply held misogyny, expressed in so many different ways

23.02.2026 19:27 👍 1 🔁 0 💬 0 📌 0

From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.

20.02.2026 21:30 👍 14 🔁 7 💬 0 📌 0

Sometimes I would like Teams to compute the net dollars spent on a meeting, estimated from a job-title-averaged equivalent hourly wage of everyone in the room.

17.02.2026 18:55 👍 2 🔁 0 💬 0 📌 0

There are lessons from WaPo’s destruction for science too.

Public funding (via NIH, NSF &c) built in the US a science superpower in large part b/c of democratic values: agencies are accountable to the public through Congress, not controlled by whims of a billionaire. Autocratic control…

04.02.2026 17:16 👍 66 🔁 20 💬 2 📌 0

So that gives them predicted muscle activations for any actor footage, which they can transfer to the equivalent but distinct muscle array under a Na'vi facial mesh. Also, there's some interesting bits in there about the difference in modeling muscles in soft tissue rather than hard joints.

01.02.2026 06:06 👍 2 🔁 0 💬 0 📌 0
VFX Artists React to Bad & Great CGi 211 Ft. Joe Letteri
VFX Artists React to Bad & Great CGi 211 Ft. Joe Letteri YouTube video by Corridor Crew

This video on Avatar 2/3 reignited this feeling: youtu.be/ueJTdtmZ5R4?.... Weta Workshop wanted to transfer actor faces to CGI Na'vi faces, which have different facial structure. So they built an anatomically inspired facial muscle model and fit it using gaussian splat meshes from video.

01.02.2026 06:06 👍 2 🔁 1 💬 1 📌 0

I would love to organize a conference bringing together neuroscientists, video game developers, and VFX artists. Visualization, spatial methods, understanding of body mechanics, they all have different perspectives on some similar problems.

01.02.2026 06:06 👍 1 🔁 0 💬 2 📌 0

All the observers in Minneapolis are damned heroes and patriots and I hope we get to celebrate them as such one day.

25.01.2026 20:11 👍 4 🔁 0 💬 0 📌 0

The last year has been a real lesson in what Orwell meant. So much energy goes into obfuscating and downplaying basic facts, since to say them clearly makes the stupidity and cruelty black and white. The second ICE murder seems to have finally broken through that a little bit.

25.01.2026 20:11 👍 7 🔁 2 💬 1 📌 0
Preview
Pyramidal neurons proportionately alter cortical interneuron subtypes - Nature Pyramidal neuron-driven mechanisms actively promote the survival and terminal differentiation of their associated interneuron subtypes.

Excited for the publication of our recent work on how pyramidal cells shape the identity of interneurons in the Cortex! Big shout out to @artofbiology and Sherry Jingjing wu! www.nature.com/articles/s41...

22.01.2026 17:04 👍 58 🔁 15 💬 0 📌 2

Please apply. Amazing opportunity to dive into connectomics datasets for research, educational initiatives, outreach and whatever else your heart desires. Feb 2nd deadline.

15.01.2026 00:17 👍 2 🔁 5 💬 0 📌 0

Just to link to science, if you have used CATMAID to look at neural circuits in the fly or the larva, he laid the groundwork for the reconstruction and exploration you see today.

15.01.2026 19:45 👍 4 🔁 0 💬 1 📌 0

I wish more people could have known him. Goodbye Mark, and thank you for so many good times, excellent board game sessions, and fascinating conversations.

15.01.2026 04:35 👍 3 🔁 0 💬 1 📌 0

... and he passed away last weekend. I'm so glad that I was able to see him (which I hoped was the first of many times), Especially amidst all the bullshit right now it's just so upsetting that a kind, thoughtful person who was a benefit to the world and all those who knew him is gone far too soon.

15.01.2026 04:35 👍 2 🔁 0 💬 1 📌 0

Soon we became good friends. When the lab moved, he moved back to England and build digital tools for improving civil society. After many years, I saw him in London over lunch last year and caught up too briefly. Devastatingly, not even two weeks ago I found out that he was very sick...

15.01.2026 04:35 👍 2 🔁 0 💬 1 📌 0

Back in 2010, I moved to Zürich with two suitcases. I knew no one there, but was tremendously lucky in that the other postdoc in my group at the time was this fellow named Mark. Within the first day or two, he invited me out to watch a World Cup game at one of the many outdoor bars there.

15.01.2026 04:35 👍 7 🔁 0 💬 1 📌 0

I think that’s a key point: how large is the space of possibilities and how much of it is covered by the modeling approach? That said, I also think of Barbara Webb saying “model early and often” to get true iteration in ideas and experiments and analysis. No one size fits all here.

12.01.2026 18:02 👍 1 🔁 1 💬 1 📌 0

As an extreme example, I am thinking of a paper that made a model of brain network generation and tested against the fly connectome. Except we know a lot about actual development and it looks nothing like the model, so agreement with the model’s network stats doesn’t actually say much about biology.

12.01.2026 17:46 👍 1 🔁 0 💬 1 📌 0

Narratively, model first seems right if the model solves an existing but thorny problem or shows novel consequences of common beliefs. Otherwise, it can be hard to interpret either agreement or falsification of a relatively arbitrary model.

12.01.2026 17:46 👍 1 🔁 0 💬 1 📌 0

Great post as usual! Btw, for MICrONs, the rationale behind the foundation model was to be able to do virtual experiments across the whole EM volume even when it was imaged across many different sessions and days. One can discuss the outcome, but the idea makes sense.

31.12.2025 07:23 👍 2 🔁 0 💬 0 📌 0

Hard to think of a person who brought so many good emotions to so many people as Rob Reiner. What an upsetting end to an upsetting weekend.

15.12.2025 06:59 👍 0 🔁 0 💬 0 📌 0

SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE

10.12.2025 17:10 👍 13600 🔁 4858 💬 108 📌 228

Connectomics has a great presence here, with several instructors from our team! Apply if you want hands on training and feedback on working with cortical connectomics (and whatever else we might have available by then...)!

12.12.2025 17:30 👍 3 🔁 1 💬 0 📌 0