Communications Medicine

Glioblastoma zebrafish Avatars guide therapeutic decisions in a patient with gliosarcoma: a case report - Communications Medicine Fontes et al. report a case study of a person with recurrent glioblastoma for whom patient-derived zebrafish xenografts (zAvatars) were used to test 13 off-label therapies with radiotherapy. zAvatars identified pemetrexed and doxorubicin as effective, guiding treatment that stabilized the patient.

🚨 NEW RESEARCH! ⚕️ 🩺

Fontes et al. share a case report of a glioblastoma patient's sample use in generating patient-derived zebrafish xenografts (zAvatars) and subsequent testing of therapeutic options.

http://dlvr.it/TRKtHr #Glioblastoma #ZebrafishModels

Dolutegravir use is related to lower HTLV-1 proviral load in people co-infected by HIV-1 - Communications Medicine Fernandez et al. compare the HTLV-1 proviral load in people with HIV-1-HTLV-1 coinfection on stable antiretroviral therapy or people with HTLV-1 single infection without antiretroviral therapy. Dolutegravir use for longer than six months is associated with lower HTLV-1 proviral load.

🚨 NEW RESEARCH! ⚕️ 🩺


Fernandez et al. assess Dolutegravir use and HTLV-1 proviral load in HIV-HTLV-1 coinfected patients.

http://dlvr.it/TRJkWj #AntiretroviralTherapy #HTLV1

Hyperspectral imaging as an objective diagnostic tool for secondary lymphedema in breast cancer patients - Communications Medicine Weiss et al. evaluate hyperspectral imaging as an objective and noninvasive method for detecting secondary lymphedema after breast cancer treatment. Results show that hyperspectral imaging provides stronger correlations with disease stage than conventional methods.

🚨 NEW RESEARCH! ⚕️ 🩺

Weiss et al. show that hyperspectral imaging provides reproducible and noninvasive assessment of secondary lymphedema supporting its use as a diagnostic and monitoring tool to improve staging for breast cancer patients.

Contraceptive-induced menstrual changes in low- and middle-income countries: a systematic scoping review - Communications Medicine Makama et al. comprehensively review the prevalence, health impact, treatment, and barriers to accessing treatment for contraceptive-induced menstrual changes in low- and middle-income countries. They highlight the importance of contraceptive counselling and need for investment in innovative therapeutics and novel approaches to contraception.

🚨 NEW RESEARCH! ⚕️ 🩺

Makama et al. examine the impact of contraceptive-induced menstrual changes in #LMIC, highlighting the importance of contraceptive counselling.

http://dlvr.it/TQzrLb
#WomenHealth

Risk factors for spontaneous preterm birth are mediated through changes in cervical length - Communications Medicine Wolf et al. examine the impact of maternal risk factors on gestational duration mediated by changes in cervical length during pregnancy. Their study finds that previous preterm birth, pre-pregnancy BMI, parity, and previous abortion have unique influences on preterm birth risk through linear changes in the cervix.

🚨 NEW RESEARCH! ⚕️ 🩺

Wolf et al. examine risk factors for spontaneous preterm birth, identifying risk factors related to cervical length.

http://dlvr.it/TQxKsR
#PregnancyResearch

Responses to active stand test predict 12-year incident cardiovascular disease and mortality - Communications Medicine Hernández et al. examine the link between heart rate and blood pressure response to active standing and future cardiovascular disease (CVD). Findings reveal distinct haemodynamic patterns linked to higher mortality and CVD risk, highlighting its potential as a marker for cardiovascular health.

🚨 NEW RESEARCH! ⚕️ 🩺

Hernandez et al. find a link between heart rate and blood pressure response to active standing and future cardiovascular disease🫀

Genomic platform specific polygenic risk scores impact breast cancer risk stratification - Communications Medicine Ho et al. investigate the impact of choice of sequencing platform on identification of specific variants for breast cancer risk stratification. Platform-specific variability is found to influence PRS313 estimates, potentially reclassifying individuals around clinically relevant thresholds.

🚨 NEW RESEARCH! ⚕️ 🩺

Ho et al. find that the choice of sequencing platform influences the identification of specific variants for breast cancer risk stratification.

http://dlvr.it/TQv4pK

#BreastCancer #PolygenicRiskScores

Evaluating spoken language as a biomarker for automated screening of cognitive impairment - Communications Medicine Lima et al. evaluate predictive models that detect cognitive impairment and predict disease severity from spoken language features. Their approach identifies linguistic indicators of cognitive decline and enables clinically actionable triage with risk stratification, offering a pathway for scalable in-home monitoring.

🚨 NEW RESEARCH! ⚕️ 🩺

Lima et al. evaluate spoken language as a biomarker for automated screening of cognitive impairment.

http://dlvr.it/TQswfR
#CognitiveHealth

Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline - Communications Medicine He et al. develop a network-based metric of amyloid-β burden by integrating individualized brain connectomes with amyloid-PET imaging. This approach improves prediction of future cognitive decline in older adults and may support earlier identification of individuals at risk of dementia.

🚨 NEW RESEARCH! ⚕️ 🩺

He et al. develop a model that improves the prediction of future cognitive decline when integrating individualized brain connectome with amyloid pathology.

http://dlvr.it/TQrpVk
#CognitiveDecline

Longitudinal clinical trial enrollment trends across 341 US FDA-approved drugs and their guiding role in precision medicine strategies - Communications Medicine Zaaijer and Groen assess enrollment demographics across 341 FDA-submitted pivotal trials (2017–2023) supporting 348 approved drugs. They report persistent underrepresentation of Black and Hispanic individuals—especially in cancer and rare disease trials—alongside higher Black enrollment when trials are US-based and rising Asian participation.

🚨 NEW RESEARCH! ⚕️ 🩺

Zaaijer and Groen assess clinical trial enrollment demographics revealing an underrepresentation of specific groups, especially in cancer and rare disease trials.

http://dlvr.it/TQp50q
#PrecisionMedicine #HealthEquity

Global burden and geospatial drivers of sensory impairment with sense organ disease projections to 2050 - Communications Medicine Ma, Zan, Li et al. assess the global burden of sense organ diseases from 1990-2021 using Global Burden of Disease data from 204 countries. Results reveal increasing global burden of sensory organ diseases linked to aging populations and nighttime light exposure, with YLDs projected to rise by 2050, underscoring the need for targeted interventions.

🚨 NEW RESEARCH! ⚕️ 🩺

Ma, Zan, Li et al. examine the global burden of sense organ diseases revealing an increase that is linked to the aging population and nighttime light exposure.

http://dlvr.it/TQmtNF
#GlobalBurden

Short-term animal product dietary restriction alters metabolic profiles and modulates immune function - Communications Medicine Loizidou, Palaiokrassa, Asiedu, et al. study individuals who alternate between being omnivorous and avoiding animal products for religious reasons. Results reveal widespread changes in health-related biomarkers in a direction suggesting positive effects on health, along with signs of lower inflammation during animal product restriction.

🚨 NEW RESEARCH! ⚕️ 🩺

Loizidou, Palaiokrassa, Asiedu et al. explore changes in metabolic profiles and immune function following short-term animal product dietary restriction.

The effect of clinically relevant changes in extracellular electrolyte concentrations on human atrial arrhythmias - Communications Medicine Corrado et al. use cardiac digital twins from 100 atrial fibrillation patients to evaluate how electrolyte imbalances influence atrial electrophysiology and arrhythmia risk. Hyponatremia is identified as a key determinant of sustained AF, while hypokalemia modestly increases the likelihood of arrhythmia onset.

🚨 NEW RESEARCH! ⚕️ 🩺

Corrado et al. use cardiac digital twins to investigate electrolyte imbalances in atrial fibrillation🫀

http://dlvr.it/TQkSbk

#DigitalTwins #HeartHealth

The role of the salience network in adolescent impulsivity using memory tasks and neuroimaging - Communications Medicine Kim et al. investigate behavioral and neural markers of adolescent impulsivity using memory tasks and resting state fMRI. Stronger functional connections between the brain’s salience network, including the insula and dorsal anterior cingulate, and the locus coeruleus serve as a neural indicator of higher impulsivity in teenagers.

🚨 NEW RESEARCH! ⚕️ 🩺

Kim et al. examine behavioral and neural markers of adolescent impulsivity using memory tasks and fMRI.

http://dlvr.it/TQjFFz
#AdolescentPsychology

Dietary intake, nutritional status, and health outcomes among vegan, vegetarian, and omnivorous Czech families - Communications Medicine Heniková, Ouřadová et al. conduct a cross-sectional study among Czech families with long-term vegan, vegetarian, and omnivorous families to compare clinical outcomes, nutritional status, and diet adequacy. They show that vegans have comparable growth characteristics and signs of better cardiometabolic health, while having lower iodine status.

🚨 NEW RESEARCH! ⚕️ 🩺

Henikova, Ouradova et al. examine health outcomes among vegans, vegetarian and omnivorous Czech families.

http://dlvr.it/TQfYd6

@jangojda.bsky.social
#NutritionResearch

Integrating large scale genetic and clinical information to predict cases of heart failure - Communications Medicine Kuan-Han et al. examine if integrating patient genetic and clinical information from electronic health records can better predict heart failure in patients. Their findings show improvement in heart failure prediction up to ten years prior to diagnosis, which is two years earlier than using a single risk score alone.

🚨 NEW RESEARCH! ⚕️ 🩺

Kuan-Han et al. integrate genetic and clinical information from patient EHRs to better predict heart failure🫀

http://dlvr.it/TQdhjv
#HeartHealth

Kidney Disease and Health This is a joint Collection across Communications Medicine, Nature Communications, Communications Biology, and Scientific Reports. We welcome the submission of ...

🚨 OPEN COLLECTION! ⚕️ 🩺

“Kidney Disease and Health”

We welcome submissions of papers that advance our understanding of Kidney Disease and Health. This is a joint collection with @natcomms.nature.com and @commsbio.nature.com

http://dlvr.it/TQVgfv
#KidneyHealth

Wearable devices for anxiety assessment: a systematic review - Communications Medicine Elgendi and Markov et al. systematically review 26 studies on wearable devices that use physiological signals such as heart activity, breathing, skin responses, and blood flow to detect anxiety. They find that combining multiple signals improves accuracy over single-signal methods, highlighting the potential of wearables for anxiety detection.

🚨 NEW RESEARCH! ⚕️ 🩺

Elgendi and Markov et al. systematically review studies using wearable devices to detect anxiety.

http://dlvr.it/TQTT1C
#DigitalHealth #AnxietyManagement

A comprehensive study of cognitive control in healthy aging - Communications Medicine De Pue et al. administer a cognitive control test battery measuring inhibition, updating, shifting, and proactive and reactive control in young and older adults. While some cognitive control functions decline with age, others are spared or even improve, highlighting the importance of distinguishing multiple cognitive control functions.

🚨 NEW RESEARCH! ⚕️ 🩺

De Pue et al. find differences in cognitive control with healthy aging.

http://dlvr.it/TQMjtf

#HealthyAging
@sarahdepue.bsky.social
@evdbussc.bsky.social
@neuropsylab.bsky.social

Nanomedicine Applied in Cancer Treatment Failure This cross-journal collection will consider submissions of research articles that highlight advances in nanomedicine aimed at overcoming cancer treatment ...

Submissions are now open for our new collection on Nanomedicine Applied in Cancer Treatment Failure, launched jointly with @natcomms.nature.com and @commsmed.nature.com 💉

For more information, visit www.nature.com/collections/...

Clinical recognition of frontotemporal dementia with right temporal predominance: a consensus statement from the International Working Group - Communications Medicine Ulugut et al. examined the right anterior temporal variant of frontotemporal dementia by integrating a systematic review and expert consensus across 52 centers worldwide. The study defines the core domains of impairment and establishes unified phenotypic nomenclature to improve diagnostic precision and management.

🚨 NEW CONSENSUS! ⚕️ 🩺

Ulugut et al. introduce a consensus across 52 centers worldwide on the right anterior temporal variant of frontotemporal dementia.

https://bit.ly/4q5p1JV
#MedicalConsensus #BrainHealth

The role of the salience network in adolescent impulsivity using memory tasks and neuroimaging - Communications Medicine Kim et al. investigate behavioral and neural markers of adolescent impulsivity using memory tasks and resting state fMRI. Stronger functional connections between the brain’s salience network, including the insula and dorsal anterior cingulate, and the locus coeruleus serve as a neural indicator of higher impulsivity in teenagers.

🚨 NEW RESEARCH! ⚕️ 🩺

Kim et al. investigate the behavioral and neural markers of adolescent impulsivity and find key functional connectivity differences.

https://bit.ly/4jncTkY
#AdolescentHealth

Extraskeletal osteosarcoma harboring ETV6::NTRK3 fusion treated successfully with larotrectinib: a case study - Communications Medicine Skok, Ochsenhofer et al. present the first reported instance of extraskeletal osteosarcoma with an NTRK fusion. The rapid and sustained response to larotrectinib highlights the potential of precision medicine in managing rare and aggressive tumors, emphasizing the importance of molecular profiling to identify actionable targets.

🚨 NEW RESEARCH! ⚕️ 🩺

Skok, Ochsenhofer et al. present a case study of an individual with extraskeletal osteosarcoma harboring a NTRK fusion who was treated successfully with larotrectinib.

https://www.nature.c...

@kristijanskok.bsky.social
#Osteosarcoma

Disorder of consciousness rather than complete Locked-In Syndrome for end stage Amyotrophic Lateral Sclerosis: a case series - Communications Medicine Gobert et al. investigate whether consciousness persists in end-stage Amyotrophic Lateral Sclerosis, traditionally assumed as being fully aware but unable to communicate. Multimodal assessments, including Brain-Computer Interface, suggest some individuals may show degenerative disorder of consciousness rather than a complete Locked-In Syndrome.

🚨 NEW RESEARCH! ⚕️ 🩺

Gobert et al. investigate whether consciousness persists in end-stage ALS, suggesting that some individuals may show degenerative disorder of consciousness rather than Locked-In Syndrome.

https://www.nature.c...
#ALS #LockedInSyndrome

Monitoring for early prediction of gram-negative bacteremia using machine learning and hematological data in the emergency department - Communications Medicine Chiu et al. developed a machine learning model using routine blood test data, including complete blood count, differential count, and cell population data, to predict bloodstream infections in emergency department patients. The model accurately identifies Gram-negative bacteremia, supporting earlier diagnosis and timely care.

🚨 NEW RESEARCH! ⚕️ 🩺 🖥️

Chiu et al. develop a machine learning model using blood test data to predict bloodstream infections in ED patients.

https://www.nature.c...
#EmergencyMedicine #ML

Federated task-adaptive learning for personalized selection of human IVF-derived embryos - Communications Medicine Gao et al. propose FedEmbryo, a federated task-adaptive learning (FTAL) approach that dynamically adjusts task and client contributions based on learning feedback, enabling privacy-preserving, decentralized training across multiple clinical sites to improve IVF outcomes. FedEmbryo demonstrates superior performance in both morphological evaluation and live-birth outcome prediction, thereby enhancing the accuracy of high-quality embryo selection.

🚨 NEW RESEARCH! ⚕️ 🩺

Gao et al. propose a federated task-adaptive learning approach to improve #IVF outcomes.

https://bit.ly/44G6HOX

#ReproductiveHealth

Air pollution and dynamic transitions of preserved ratio impaired spirometry in UK Biobank - Communications Medicine Han, Pan et al. analyse longitudinal lung function changes in UK Biobank to assess the impact of air pollution. They show that pollutants increase the risk of progression to chronic obstructive pulmonary disease (COPD) and hinder recovery from pre-COPD to normal lung function, revealing a dual pathway by which pollution harms respiratory health.

🚨 NEW RESEARCH! ⚕️ 🩺

Han, Pan et al. find that air pollution increases the risk of progression to Chronic Obstructive Pulmonary Disease (COPD) using data from the UKbiobank cohort.

https://bit.ly/49lUr8T
#COPD #PublicHealth

Structural genetic variants, from detection to phenotype This cross-journal Collection with Communications Biology, Communications Medicine, Nature Communications and Scientific Reports invites submissions focusing ...

🧬🔍 Submissions are still open for our Structural genetic variants, from detection to phenotype Collection, a cross-journal Collection with @commsmed.nature.com, @natcomms.nature.com and Scientific Reports!

More details here 👇
www.nature.com/collections/...

Clinical validation of noninvasive blood glucose measurements by midinfrared spectroscopy - Communications Medicine Kaluza et al. present a clinical evaluation of a noninvasive glucose measuring system based on infrared excitation of glucose in skin and photothermal detection at the skin surface. The results demonstrate an accuracy comparable to early minimally invasive glucometers and could improve diabetes management.

🚨 NEW RESEARCH! ⚕️ 🩺

Kaluza et al. present a clinical evaluation of a noninvasive glucose measuring system based on infrared excitation of glucose in the skin to improve diabetes management.

https://bit.ly/4q7C7G9
#HealthTech #GlucoseLevels

I am super proud of this new paper and all the hard work of the great @sarahdepue.bsky.social! Our aim was to offer a more comprehensive view on cognitive control in aging, testing over 200 older adults. So much work, but also very rewarding! Published open access in @commsmed.nature.com 🎉