Peter Carlton

I think a good thing to do would be to open a new lab studying Drosophila elegans and Caenorhabditis drosophilae, and act as if this was the self-evident default, gasping "that's a crazy fly-worm mashup!" when you hear someone say Caenorhabditis elegans.

Circos-style contact maps in ChimeraX:
cxtoolshed.rbvi.ucsf.edu/apps/chimera...

A screenshot of numbers counting up to a trillion, currently showing the range from one hundred thirteen billion, fifty-four million, three hundred and fifty-seven thousand, six hundred sixty-six to one hundred thirteen billion, fifty-four million, three hundred and fifty-seven thousand, six hundred seventy-one.

I started a loop counting to 1 trillion (兆) in my terminal last week since my 5yo just learned a bunch of words for higher numbers … it's been fun checking it every morning. It should finish sometime this month!

I thought TV show theme songs were all sung by the actors - because who else would be singing them?

Wet Bags of Atoms Teaching Sand to Think: On emergence, and the lazy dismissal of AI as "just next token prediction" as a thought-terminating reductive cliche that we need to abandon. blog.stephenturner.us/p/wet-bags-o...

Did anyone see Rob Hubbard sneak in to the studio??

A photo of a classic two-button and scrollwheel blue logitech mouse with a USB cord as god intended

I was thrilled finding one of these ↓ in a lab closing giveaway, since it got me through the early 2000s and is still my favorite.

What a glorious bit of nerd lore I was not at all aware of: why ^H is delete, ^[ is ESC, etc:
garbagecollected.org/2017/01/31/f...

Fluorescence micrograph. Emma Miller and Alex Merz, unpublished.

🧵 After years out of the field, I and my lab are again working on bacterial type IV pili. We have just posted our first preprints, and I'm excited to share what we have discovered.

This shows Neisseria gonorrheae bacteria infecting a human epithelical cell. Here, you can see the pili in red.

1/

Or did she knock out its ATM and ATR before she gave it to you?

That's the thing about this sequence, no matter how many you add it's still not "complete"!
I chose X and O since it shows self-similarity if you highlight X or O

Didn't think about that but it makes sense! for me it was actually this pattern I remember being completely obsessed with when I was around 10; I had a real compulsion to keep reciting/imagining it. I've heard of a few other people reporting the same thing.

Question for the hivemind: does

oxxo xoox xoox oxxo
xoox oxxo oxxo xoox
xoox oxxo oxxo xoox
oxxo xoox xoox oxxo

mean anything to you?

Age verification?

LOAD "*",1

PRESS PLAY ON TAPE

Curious why བྲོ and not ཌོ for a loanword

Protein structure is more conserved than sequence. Work in 2020 (MBE: academic.oup.com/mbe/article/...), showed 3D data unlocks deeper evolutionary signals. A thought was why not go higher than 3D? 🧵

#Phylogenetics #StructuralBiology #Structome #Evolution #StructuralPhylogenetics #StrPhy

You can totally point out that some aspects of AI are overhyped, you can believe that AGI is not possible, you can criticize how the companies and governments developing AI are using or being coopted by these tools. There is a lot to criticize.

But "it doesn't work and is fake" is just wrong now.

ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements https://www.biorxiv.org/content/10.64898/2026.01.30.702899v1

Seattle bread? This is intriguing to me and I would like to subscribe to your newsletter.

“If the Minnesota resistance has an overarching ideology, you could call it “‘neighborism’—a commitment to protecting the people around you, no matter who they are or where they came from...their neighbors are their neighbors whether they were born in Minneapolis or Mogadishu.”

It was only -16° up on 八甲田山 田茂萢岳 (Mt Tamoyachi I guess) but the flying shards of ice made it seem more like North Neptune

A sign whose windward side has become encrusted with ice growing out 10 centimeters in the surface

In the Hakkōda mountains in Aomori today, 4m of snow

2️⃣ A holocentric pangenome links karyotype evolution to meiotic recombination

🔄 Structural variation and recombination landscapes are tightly intertwined in holocentric systems.
🔗 doi.org/10.64898/202...

📢 Three new #bioRxiv preprints from our team on holocentric chromosomes.

Together, they connect centromere repeat evolution, karyotype dynamics, and meiotic recombination outcomes, revealing how holocentric genomes evolve and function. 🧬👇

Also fascinating how they're arranged in a single line…what side of the tree is that (north for maximum shade?)

I'm shocked that after 2000 years of this definitely never having happened yet, it's really and newsworthingly happening now!

JANUS
'Tis well an old age is out,
And time to begin a new.

CHORUS OF ALL
All, all of a piece throughout;
Thy chase had a beast in view;
Thy wars brought nothing about;
Thy lovers were all untrue.
'Tis well an old age is out,
And time to begin a new.

Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy - FocalPlane Imaging spotlight: Initiation of chromosome congression deconstructed by multi-scale live lattice light-sheet and super-resolution microscopy - News

🔬🔦Our latest imaging spotlight is from Kruno Vukušić @krunovuk.bsky.social & Iva Tolić @ivatolic.bsky.social, describing their research using multi-scale live lattice light-sheet microscopy & super-resolution microscopy to interrogate the earliest steps of chromosome congression.

If you are in the Seattle area, come see me on February 3 at the Barnes and Noble UW Book Store. I'm holding a talk, reading, and book signing for my book Chinese Characters Across Asia: How the Chinese Script Came to Write Japanese, Korean, and Vietnamese.

stores.barnesandnoble.com/event/978006...

Added many features (search, phylogenetic tree navigation, session persistence) to the excellent terminal-based multiple sequence alignment viewer github.com/sib-swiss/termal and have made a landing page at msafara.carltonlab.org