Delighted to see this published: H3K115 acetylation is associated with fragile nucleosomes at CpG island promoters and active regulatory sites. Great work from all contributors; Yatendra Kumar, @illingworth-lab.bsky.social @eliasfriman.bsky.social @helink.bsky.social
doi.org/10.7554/eLif...
New pre-print identifying 29 Covid GWAS variants that drive allele-specific activity in a functional genomics screen in lung cells, from @gweykopf.bsky.social and
@eliasfriman.bsky.social @simonbiddie.bsky.social
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
@uk-fgx.bsky.social
Waiting for reviewer 3
The Galway Statute enacted in Ireland in 1527 banned certain types of ball games, including games using "hooked" (written "hockie", similar to "hooky") sticks.
Dont think ice hockey was a thing in 1527
Nice review of 3D interactions medicated by polycomb. Also worth considering this study showing how such interactions can be rapidly and reversibly disrupted by hexanediol.
www.life-science-alliance.org/content/6/10...
Delighted to see Charlotte "Lotte" Auerbach celebrated in the
@royalsociety.org #WomenInSTEM History map of the UK. First woman to be awarded the Royal Society’s Darwin Medal and an inspirational life history.
royalsociety.org/news-resourc...
Reminds me of Shine (singing in Gaelic)
shinetrio.bandcamp.com/track/alasda...
Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social
But please more focus on 2 things...
1) Immediate effects (eg funding decisions expected in March)
2) Likely disproportionate effects on early career scientists
www.bbc.co.uk/news/article...
So richly deserved
So sorry to hear that Pradeep. Keeping my fingers crossed for you.
... and we're off. Great kick-off meeting for the start of the ERC synergy GeneMotors project. So much energy and enthusiasm. @ceesdekker.bsky.social @erc.europa.eu
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate).
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
Nature research paper: A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation
go.nature.com/4pDVgPq
Delighted to have a contribution in this issue together with @eliasfriman.bsky.social
Phenylalanine-phenylalanine-serine!
The world’s problems may seem so huge that you feel helpless, but small innovations by smart people can make a world of difference.
🫣
My first Reith Lecture is now out in video form: A Time of Monsters.
On moral decay, elite cowardice, and why we need a moral revolution. Watch here 👉 youtube.com/watch?v=fUJ-...
(With one tiny edit at 4:28, for those who notice such things 😉)
Many congratulations
😀
Am I in my office, or in a Disney film? Sometimes Edinburgh just takes your breath away.
Absolutely fabulous- hope you continue to have a wonderful trip.
Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...
Excited to start working on this BBSRC sLola project to decode the semantic rules of large regulatory domains, led by @ferencmueller.bsky.social with colleagues from Birmingham, Manchester, Crick, MRC-LMS and EBI-ENSEMBL
institute-genetics-cancer.ed.ac.uk/decoding-the...
bsky.app/profile/fere...
1. We start a major consortium programme funded by the sLoLa of BBSRC (shorturl.at/aUbnt) to decipher the semantic rules of enhancer arrangements driving regulator genes of development (shorturl.at/6qcjW).
To advance our knowledge about the role of ecDNAs in cancer, it would be helpful if people could at least acknowledge that not everyone concludes that ecDNAs form "hubs" in the nucleus.
pubmed.ncbi.nlm.nih.gov/40972571/
pubmed.ncbi.nlm.nih.gov/41237767/
pubmed.ncbi.nlm.nih.gov/36476408/
I just tried it out on a manuscript I am preparing. Impressed. Succinct summary of major claims and whether they are justified based on experiments done. Even more it pointed out a caveat that I hadn’t thought about and that I can now address.
Chicken and egg - the two are related!!
I’m fascinated to try this. It’s such a relief to see the journey we are on that started with the launch of BioRxiv and that could liberate us from the most depressing aspect of science - “getting published”.
