Saskia Freytag

The BrainPOP research team (left to right): Professor Kate Drummond, Dr Jim Whittle, Dr Saskia Freytag, Dr Sarah Best

Researchers from WEHI, the Royal Melbourne Hospital & @petermaccc.bsky.social have achieved a brain cancer clinical trial world-first, providing hope to patients with low-grade gliomas.

🔗 www.wehi.edu.au/news/world-f...

Perioperative IDH inhibition in treatment-naive IDH-mutant glioma: a pilot trial - Nature Medicine This pilot trial showed that perioperative treatment with the isocitrate dehydrogenase (IDH) inhibitor safusidenib of patients with low-grade IDH-mutant glioma, with craniotomy and lumbar puncture bef...

A landmark research milestone, from a brilliant collaborative team, published in @natmed.nature.com

🔗 www.nature.com/articles/s41...

@sarahannbest.bsky.social @saskiafreytag.bsky.social tag.bsky.social @jimwhittle.bsky.social

Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...

First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵

Brain-wide neuronal circuit connectome of human glioblastoma www.nature.com/articles/s41...

New review article from the lab discusses everything GBM tumor microenvironment: tech (spatial transcriptomic, metabolomics and proteomics), biology and implications for the clinic.
@jimwhittle.bsky.social
@sarahbest.bsky.social

www.sciencedirect.com/science/arti...

New work from the lab on comparing patient-derived GBM organoids & spheroids. TLRD: Surprisingly very similar across genetic, transcriptomics and epigenetic levels!

Beautiful collaboration! Congratulations.