STEMCELL Science News

Researchers found that in early prostate cancer, FUS represses #AndrogenReceptor activity and tumor progression, leading to its down-regulation.

Read the paper in Oncogene! 📚

https://go.nature.com/4aII47y

Scientists from the Korea Research Institute of Bioscience and Biotechnology report the development of a patient-specific, #iPSC-derived multi-organ pharmacokinetics/pharmacodynamics evaluation platform for NF1-mutant #BreastCancer. | @sigtrans-sttt.bsky.social

🧫 https://go.nature.com/46J1Y05

New in @nature.com!

Researchers led by Dr. Pedram Razavi of @mskcancercenter.bsky.social shows that tumors with germline #BRCA2 mutations are more likely to lose RB1 during CDK4/6 inhibitor treatment, leading to drug resistance and worse outcomes.

https://go.nature.com/4l8mZXQ

🧫 Using a hyaluronic acid-based hydrogel platform to model normal and fibrotic lung mechanics, scientists examine the roles of Piezo1 and cadherin-11 in interleukin-6-mediated fibroblast activation.

👉 https://rsc.li/4sv5jIC

Published in @cp-cell.bsky.social!

Researchers develop a next-generation extracellular targeted protein degradation platform for degrading extracellular amyloid-β in Alzheimer's disease.

💡 Learn more: https://bit.ly/3NiKeSu

What actually shapes a career in science?

In Season 3 of the Lab Coats & Life™ Podcast, launching March 11, we zoom out from the bench to examine the systems surrounding researchers. 🔍

Listen wherever you get your podcasts, starting next week! Or catch up on our previous two seasons now. 🎧

Congratulations to all on this exciting new release! 🎉

🦴 Researchers explored a neural crest-like progenitor niche in bone marrow MSCs with high neurogenic and proliferative capacity by single-cell transcriptomics.

👉 https://go.nature.com/3N8Tzwd

🧪 Investigators elucidated the potential mechanism of a traditional therapy for #vitiligo and identified CASP7 and EP300 as potential key targets.

Fufang Baizhi Tincture was found to regulate melanocyte apoptosis and transcription.

🔗 https://bit.ly/4799WQ5

Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential - npj Biomedical Innovations npj Biomedical Innovations - Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential

Dr. @kolade-adebowale.bsky.social's team reviews macrophage mechanobiology and the potential of engineered macrophages, using genetic or non-genetic “Trojan horse” strategies, to deliver therapies and reshape the immunosuppressive TME.

👣 Follow the link: https://go.nature.com/4rKWHNP

This study, co-authored by Dr. Song Guo Zheng, identifies a previously unrecognized role of CD8+ T cells in enhancing induced #Treg differentiation, stability, and suppressive function through the ROS/TGF-β–IRF4 pathway.

🔎 Discover more: https://bit.ly/4aLxZWc

#OpenAccess

Up close and personal with a branching neurite in a DIV2 hippocampal neuron expressing FTractin-GFP. This was imaged every 6 seconds over 10 minutes on the trusty @zeiss-microscopy.bsky.social LSM880. Happy #FluorescenceFriday

🌱 Scientists investigated the therapeutic potential of Plant-Derived Exosome-like Nanoparticles, particularly those from Poria cocos-Derived Exosome-like Nanoparticles, in treating lymphedema.

https://bit.ly/4asFZwv

Check out this #PhD opportunity in Dr. @ostaufer.bsky.social's group! 👇

Happy to share (and proud to have contributed) to this new PDAC paper on ASC/PYCARD: cancer-cell ASC links innate immunity to mitochondrial metabolism—and extracellular ASC speck targeting with nanobodies suppresses tumorigenesis in vivo. 🤩
www.nature.com/articles/s41...

Scientists from Shandong University present a comprehensive timeline detailing the development of #antiviral drugs, tracing the progression from early viral inhibitors to modern broad-spectrum antiviral agents. 💊

📚 Read their @sigtrans-sttt.bsky.social review: https://go.nature.com/4rCgtLh

Researchers at @harvard.edu led by Drs. Jia Liu and Juan R. Alvarez-Dominguez show that implanted flexible electronics reveal principles of human islet cell electrical maturation.

📕 @science.org
🔖 https://bit.ly/40sJY6k

Led by Drs. Matthew Miller & @manishbutte.bsky.social, human CAR-T cells were equipped with proteins derived from fungi that enable hydrolysis of cellobiose.

Cellobiose supplementation during glucose withdrawal restores anti-tumor T cell function. | @cellpress.bsky.social

bit.ly/4tQSIkg

Scientists in @harvardmed.bsky.social have created a new family of tools that, for the first time, shows the missing pieces to the puzzle on how the immune system uses cytokines to communicate with the rest of the body.

🧫 @cellpress.bsky.social: https://bit.ly/40qkk27
📰: https://bit.ly/40rN6PR

The authors at @unistrathclyde.bsky.social clarify the contribution of the renal-vascular axis to VEGF inhibitor-related toxicity, focusing on key mechanisms such as endothelial dysfunction and the activation of the renin-angiotensin-aldosterone system.

🔗 https://bit.ly/4qWvt5R

💓 Researchers at developed an in vitro cardiac inflammation model that enables controlled investigation of macrophage-cardiomyocyte interactions.

🔗 https://bit.ly/4qWSAgh

Researchers from Huazhong University found that YEATS domain-containing 2 (YEATS2) plays a critical role in promoting #ProstateCancer metastasis by suppressing #Anoikis.

Their work was recently published in Oncogene.

🤩 Learn more: https://go.nature.com/4s1sFoG

🐁 Scientists developed mouse models of sporadic and hereditary diffuse gastric cancer (DGC) by inactivation of Cdh1 in the stomach.

They generated tamoxifen-inducible Cre/loxP models of DGC driven by the Cd44 promoter with a tdTomato reporter.

https://bit.ly/4tNF6Gt

New postdoctoral opportunity @lieberinstitute.bsky.social working w/ @tsawada1.bsky.social and our Molecular Neurogenetics team using human induced pluripotent stem cells to investigate molecular, cellular and neuroendocrine mechanisms by which impaired placental function impacts brain development

Microscope image of fluorescently labeled red and green neurons in a section of brain tissue

For #FluorescenceFriday - some fresh off the scope images of intermingled (🔴 🟢) projection neurons in the mouse prefrontal cortex heading to locus coeruleus or ventral tegmental area. Image credit to Dan Olivares, @jorge-miranda.bsky.social @rehg-j.bsky.social 🔬🧠🧪

Researchers led by Drs. Pavle Boskovic, @jonykipnis.bsky.social, and Marco Colonna present amyloid-β-specific engineered CD4+ CAR-T as an approach to directly target sites of pathology for Alzheimer’s disease.

📘 @pnas.org
🔖 https://bit.ly/4aGMCv8

Scientists establish KCTD15 as a pivotal regulator of #TNBC stemness through modulation of the KLF4/β-catenin signaling axis.

📖 Read the full study to know more: https://bit.ly/4aLd9Xk

TCF1 is a master regulator of T cell stemness – but can it make exhausted cells go backwards?

We setup a CRISPR KI system to ask this question, and the answer was unexpected.

www.nature.com/articles/s41...

Public-speaking tips from the experts: what scientists can learn from comics, musicians and actors Taking to the stage to present your science is a key part of research, but talks often fall flat, says John Tregoning. Can scientists learn from performers to better engage an audience?

Turn your next conference talk into a performance that truly engages your audience! Learn public-speaking tips on timing, tone, and stepping away from the lectern to add a little showbiz to your #SciComm. 🎤 @nature.com

Dr. Aditi Shastri and team at the Montefiore Einstein Comprehensive Cancer Center reveal that a STAT3 degrader demonstrates efficacy in venetoclax resistant acute myeloid leukemia.

🔖 https://go.nature.com/4awWJmx