Graphics stating Apply to be a Preprint Editor
Preprint Editors – Development's next step into the preprint landscape
In this Editorial, @reinierprosee.bsky.social, @amjeve.uk and @jamesbriscoe.bsky.social announce a call for Preprint Editors in Development. Apply by 30 March.
doi.org/10.1242/dev....
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Planarians also reproduce asexually by fission – pulling their body in two & then regenerating the missing halves.
Breaking occurs all over development; see this recent @dev-journal.bsky.social Review from @torres-sanchez.bsky.social, @rashmi-priya.bsky.social & colleagues: doi.org/10.1242/dev....
Here are some links to things I mentioned during my talk at #gfe2026
- Summary of @biologists.bsky.social #biologists100 celebrations: www.biologists.com/100-years/
- Grants from the Company: www.biologists.com/grants/
- @dev-journal.bsky.social/HDBI meeting: www.biologists.com/meetings/dev...
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Read the Research Article ‘Foxn3 is part of a transcriptional network that regulates primary cilia in the developing retina’ here:
doi.org/10.1242/dev....
Increased and ectopic amacrine cells and astrocytes in Foxn3 KO retinas. (A,B) Sections from wild-type (WT) and Foxn3 KO P21 retinas analyzed by immunofluorescence; enlarged inset regions indicated by boxed area. Foxn3 KO retinas have ectopic amacrine cells (labeled with AP2α, white nuclei) and glial cells (labeled with Sox9, magenta nuclei) in the IPL, as well as increased displaced amacrine cells and Sox9+ glial cells in the GCL. In the INL, amacrine cells, bipolar cells (labeled with Vsx2, green) and Müller glia (Sox9+ nuclei in INL) were unchanged. Nuclei in the ONL (presumptive photoreceptors) were unchanged. (C,D) Quantitation, using unpaired t-test: ***P<0.001, **P<0.01, *P<0.05; ns, not significant. N=3 for Foxn3 KO and WT. Data are mean±s.d. (C) Counts from 200 µm wide windows (100 µm for ONL nuclei). (D) Counts from complete sections (see Materials and Methods). (E,F) Cells labeled by Sox9 in IPL or GCL are retinal astrocytes expressing GFAP (glial fibrillary acidic protein, green). Nuclear DNA: blue. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; ONL, outer nuclear layer.
Foxn3 represses cilia genes in the developing retina
This Research Highlight showcases work by Huanqing Zhang, David Turner and colleagues from @umich.edu
journals.biologists.com/dev/article/...
New organisms are unlikely to evolve from single gene changes. Felicity Jones uses stickleback (with distinct ecotypes) to show morphological changes associate with non-coding DNA regions that likely regulate gene repertoires, such as fat metabolism. #gfe2026
More from @ucsdcooperlab.bsky.social ⤵️
Enhancers are genetic regions that promote the activation of neighbouring genes. @radaiglesiaslab.bsky.social asks how long-range enhancers maintain specificity by constructing synthetic gene landscapes and exploring how they affect gene activity. #gfe2026
Alvaro's @dev-journal.bsky.social Review⤵
#SY-Stem2026 has begun! Come find me during coffee breaks today and tomorrow to chat about @dev-journal.bsky.social and @the-node.bsky.social.
@imbavienna.bsky.social @viennabiocenter.bsky.social
Learn more about how the microenvironment regulates cell behaviour in @dev-journal.bsky.social's Special Issue - The Extracellular Environment in Development, Regeneration and Stem Cells #DevSIextracellular, currently being compiled for completion this summer
journals.biologists.com/dev/issue/15...
Now at #gfe2026, @katjaroeper.bsky.social shows how, in making tubes, individual cells organise supracellular 'cables' across tissues that provide zones protected from large mechanical forces, highlighting the value of cross-scale perspectives.
See Katja's recent @dev-journal.bsky.social Review⤵️
More on temperature now at #gfe2026, with @girishkalephd.bsky.social exploring how fly embryos adapt to changes in environmental temperature and why high temperatures are lethal.
Girish is one of @dev-journal.bsky.social's Pathway to Independence fellows. Learn more about Girish in this interview⤵️
Girish has also written an 'In preprints' article for @dev-journal.bsky.social: doi.org/10.1242/dev....
If you're interested in writing and commissioning these articles, Development currently has a call for Preprint Editors until 30 March
Learn more here: journals.biologists.com/dev/pages/pr...
From left to right: co-first authors, Yanel Volonté, Fabiana Herédia and Rebeca Zanini, and co-corresponding authors, Andres Garelli and Alisson M. Gontijo.
To learn more about this work and the people behind it, we talked to Yanel Volonté, Fabiana Heredia, Rebeca Zanini, Andres Garelli and Alisson M. Gontijo. doi.org/10.1242/dev....
Read the Research Article ‘Dilp8 relaxin signaling from ovarian follicle cells to Lgr3-positive neurons promotes spontaneous ovulation and oocyte quality in Drosophila’ here:
doi.org/10.1242/dev....
Model for the role of the Dilp8-Lgr3 signaling pathway in virgin reproductive physiology control. Dilp8 peptide (green circles) continuously secreted from fully mature Dilp8+ follicles (green follicles), acts (black arrows) on two populations of Lgr3-expressing neurons (brown and light-brown neurons) that innervate the lateral oviduct and uterus (R18A01), and the ovary and the lateral and common oviducts (R19B09). Activities from these neurons (thin, brown and light-brown curved arrows) facilitate ovulation and egg transit through the reproductive tract (large blue arrow) and inhibit oogenesis progression (magenta arrow) in virgin females, contributing to keeping the number of fully mature follicles below two per ovariole in the ovaries. In this model, the soma of both R18A01 and R19B09 neurons reside in the abdominal ganglion of the ventral nerve cord (VNC), but this remains to be fully confirmed (black question mark). It is possible that the lateral oviduct-innervating R18A01 neurons are sensory neurons (brown neuron near brown question marks). Collectively, these activities promote egg quality.
Dilp8/Lgr3 sets the beat of spontaneous #Drosophila ovulation
This Research Highlight showcases work by Alisson Gontijo, Andres Garelli and colleagues
journals.biologists.com/dev/article/...
Check out our conference attendance calendar to connect with our Editors at other upcoming meetings and conferences
journals.biologists.com/dev/pages/co...
We are pleased to sponsor the joint meeting on Development & Regeneration, starting this afternoon.
Visit the @biologists.bsky.social's exhibit to pick up some Development at a glance posters and postcards from @the-node.bsky.social.
Also see our Executive Editor's (@amjeve.uk) talk on Thursday.
First and corresponding author Beth M. Harvey (left), and corresponding author Michael Granato (right)
To learn more about this work and the people behind it, we talked to first author Beth Harvey and corresponding author Michael Granato, Professor of Cell and Developmental Biology at the Perelman School of Medicine, @upenncgh.bsky.social , USA. doi.org/10.1242/dev....
Read the Research Article 'A glial cell-derived pathway directs regenerating optic nerve axons toward the optic chiasm' here:
doi.org/10.1242/dev....
Lh3 is required for growth across the midline during regeneration. (A) Timeline of a transection experiment with zebrafish lh3 larvae (hpf, hours post-fertilization; dpf, days post-fertilization; hpt, hours post-transection). (B-E) Before injury, RGC axons labeled using Tg(isl2b:GFP) in siblings (B,C) and conditional lh3 mutants (D,E) cross the midline and innervate contralateral tecta. (F-H) In lh3 siblings at 72 hpt, RGC axons grow across the midline and re-innervate contralateral optic tecta, schematized in H. (I-K) In contrast, RGC axons in lh3 mutants turn away from the midline, project aberrantly (magenta arrowheads) and do not reinnervate contralateral optic tecta, schematized in K. Dashed lines indicate the outline of the eyes. Scale bars: 50 µm. Representative images of chiasms and tecta for each timepoint are of the same fixed larva, whereas across timepoints are different larvae.
Lh3 lights the way for optic nerve regeneration in #zebrafish
This Research Highlight showcases work by Beth Harvey, Michael Granato and colleagues (@upenncgh.bsky.social) .
journals.biologists.com/dev/article/...
Ready for #SYStem2026 next week?
Our Reviews Editor @saanjbati.bsky.social is also attending the whole meeting and will be available at the ‘Meet the editor’ session on 12 March 2026 during the coffee breaks to talk about @dev-journal.bsky.social and @the-node.bsky.social
@imbavienna.bsky.social
Highlighting preprint stories from within the preLights community 📽️
Here, Teodora narrates her preprint showing that functional decline in the ageing retinal epithelium results from a change in the mechanical balance of the tissue due to natural cell loss!
#Short ⬇️
www.youtube.com/shorts/CWYRX...
Check out our conference attendance calendar to connect with our Editors at other upcoming meetings and conferences
journals.biologists.com/dev/pages/co...
Our Executive Editor @amjeve.uk will be speaking at the Development & Regeneration joint international meeting of the GfE, DSDB and @sebioldev.bsky.social in Germany next week.
Visit The Company of Biologists' booth to speak to him about Development, @the-node.bsky.social & @biologists.bsky.social
excited that this work is on the cover!
See the full issue here: journals.biologists.com/dev/issue/15...
Also in Issue 4:
• 6 Research Highlights on cell division, stomach organoids, reflex circuits, teeth development, metabolism and lymphatic cells
• 5 ‘People behind the papers’ interviews
• A ‘Transitions in development’ interview
• Perspective on gene regulation
• Primer on plant PCD
On the cover: Dual HCR-FISH labelling of neural crest genes snai2 and foxd3 in Xenopus laevis embryos in various pseudocolour combinations at Nieuwkoop and Faber stages 13, 15, 17 and 20, revealing expression heterogeneity along the anterior-posterior axis. From left to right: snai2 - cyan, green, green, yellow; foxd3 - magenta, magenta, yellow, magenta.
Issue 4 is complete!
On the cover: Neural crest genes in X. laevis embryos (NF stages: 13, 15, 17 and 20). Left to right: snai2 - cyan, green, green, yellow; foxd3 - magenta, magenta, yellow, magenta.
See the Research Article by Andrew Montequin and Carole LaBonne: doi.org/10.1242/dev....
Read the Research Article ‘Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function’ here: doi.org/10.1242/dev....
