Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
Cow Tools!
We have lived alongside cows for nearly 10,000 years.
We breed them and exploit them
It is now, only now, that we have discovered THEY CAN USE TOOLS
Here I describe our study
(paper) www.sciencedirect.com/science/arti... in @currentbiology.bsky.social
with @auersperga.bsky.social
Excellent thread with links to tools whose development relied on the Chlamy dataset
The latest issue is now online www.cell.com/molecular-ce...
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
Join ML wizard Kiarash to develop BioML methods that work
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Happy Halloween! 🎃
Here's a selection of some of our scariest gargoyles and grotesques 👀
#Halloween
Join our group to optimise Relion’s optimisation algorithms!
Very excited to be able to talk about something I've been working on for a while now - we're working with Commonwealth Fusion Systems, IMO the leading fusion startup in the world, to take our work on AI and tokamaks and make it work at the frontier of fusion energy. deepmind.google/discover/blo...
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41...
The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Introducing DINOv3 🦕🦕🦕
A SotA-enabling vision foundation model, trained with pure self-supervised learning (SSL) at scale.
High quality dense features, combining unprecedented semantic and geometric scene understanding.
Three reasons why this matters👇
Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳
How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.
www.cell.com/structure/fu...
Targeted disruption of phage liquid crystalline droplets abolishes antibiotic tolerance of bacterial biofilms
led by @abultarafder.bsky.social
Great collaboration with @pearce-maths.bsky.social and @geiselbiofilm.bsky.social
www.biorxiv.org/cgi/content/...
How can we best use AI in science?
Myself and 9 other research fellows from @imperial-ix.bsky.social use AI methods in domains from plant biology (🌱) to neuroscience (🧠) and particle physics (🎇).
Together we suggest 10 simple rules @plos.org 🧵
doi.org/10.1371/jour...
Today, we release Franca, a new vision Foundation Model that matches and often outperforms DINOv2.
The data, the training code and the model weights are open-source.
This is the result of a close and fun collaboration
@valeoai.bsky.social (in France) and @funailab.bsky.social (in Franconia)🚀
Our entrance into protein design! Inverse folding steered by external sources of information, and for multiple conformations. By the amazing @kaiyi94.bsky.social and @kjamali.bsky.social!
Download our code and try it yourself. 🥳
Thanks! I did not try it on symmetric structures. However, preconditioning influences the speed of convergence to a minimum (good or not), rather than which minimum it converges to, so it's not clear to me whether it will avoid the problem you mention without running it.
Exciting study from @kiranrpatil.bsky.social and colleagues. Hannah Ochner from the group performed cryo FIB imaging.
Congrats!
“Achieving individual tomograms of cells where any features are at 10 Å resolution or better is well-beyond both current capabilities and reasonable predictions of future improvements.”
:(
We have a 3-year funded postdoc position to work on structures of #amyloid filaments. If you are an expert in protein biochemistry, structural biology or #cryoEM / #cryoET, this could be for you! Feel free to email me with any questions. Come join us! 🤩
www.nature.com/naturecareer...
We also present a solution to the problem, showing how we can efficiently estimate 2nd order information and largely mitigate the poor conditioning, opening the door for efficient, SGD-based high resolution cryo-EM methods.
We show the numerical conditioning of cryo-EM reconstruction is increasingly poor at high resolution such that SGD has no real hope of resolving high resolution structures.
Ever wonder why SGD, which works so well for ab initio cryo-EM, never seems to get to high resolution on its own? Well, we have the answer: conditioning!
Work on SGD for high-resolution cryo-EM refinement from my previous postdoc finally published in @actacrystd.iucr.org
with Roy Lederman and @marcusabrubaker.bsky.social
📜 Paper: journals.iucr.org/paper?S20597...
💻 Code: github.com/bogdantoader...
💾 Data: doi.org/10.5281/zeno...
Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi
Out in @pnas.org
Congrats @janboehning.bsky.social @abultarafder.bsky.social Miles Graham @mathieucoureuil.bsky.social
@mrclmb.bsky.social @hopitalnecker.bsky.social
www.pnas.org/doi/10.1073/...
