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Travis Gibson

@travis.gibsonlab.io

Assistant Professor - Harvard Medical School Principal Investigator - Brigham and Women’s Hospital Associate Member - Broad Institute of MIT and Harvard Gibson Lab Bluesky handle: @gibsonlab.io Gibson Lab website: gibsonlab.io

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18.09.2023
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Latest posts by Travis Gibson @travis.gibsonlab.io

It's time for the 2025 Gibbons Lab Research Roundup!

Yeehaw! 🤠 @isbscience.org

In these dark times, let the joy of scientific discovery and trainee success be your balm ❤️‍🩹

🧵...

19.12.2025 00:06 👍 18 🔁 5 💬 4 📌 1
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2025 ISB Microbiome Symposium - YouTube The 2025 ISB Microbiome Symposium was a virtual scientific event hosted by the Institute for Systems Biology (ISB) on December 12, 2025. The symposium brough...

If you missed the 2025 @isbscience.org Virtual Microbiome Symposium (theme: how microbial metabolites influence the brain, the immune system, & metabolism), the videos of the talks and the panel discussion are now available here:

youtube.com/playlist?lis...

Thanks to all who helped make it happen!

17.12.2025 16:34 👍 22 🔁 13 💬 1 📌 0
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2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB) The gut’s microbial ecosystem produces diverse metabolites that actively shape neural, immune, and endocrine function. Join leading researchers on December 12 as they share new discoveries into these ...

You still have time to register for our @isbscience.org Virtual Microbiome Symposium (Dec. 12th), with 6 speakers discussing how microbial metabolites impact the nervous, immune, and endocrine systems.

It's free! Recordings of the talks will be available afterwards.

isbscience.org/events/2025-...

10.12.2025 16:50 👍 10 🔁 3 💬 0 📌 1
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24.09.2025 01:01 👍 1 🔁 0 💬 0 📌 0
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Comment on "mbtransfer: Microbiome intervention analysis using transfer functions and mirror statistics": Implementation errors, theoretical misapplication, and methodological flaws There are a number of errors in "mbtransfer: Microbiome intervention analysis using transfer functions and mirror statistics" PLOS Comp Bio (2024) spanning multiple aspects of the paper. The wrong inp...

arxiv.org/abs/2509.16486

24.09.2025 01:00 👍 1 🔁 0 💬 1 📌 0
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Learning ecosystem-scale dynamics from microbiome data with MDSINE2 - Nature Microbiology This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.

#Newresearch

This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.

#MicroSky

www.nature.com/articles/s41...

12.09.2025 15:50 👍 23 🔁 9 💬 0 📌 0
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Learning ecosystem-scale dynamics from microbiome data with MDSINE2 - Nature Microbiology This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.

www.nature.com/articles/s41...

09.09.2025 11:36 👍 0 🔁 0 💬 0 📌 0

Our paper demonstrating that within-species warfare interactions are ecologically important on human skin is now published in Nature Micro! www.nature.com/articles/s41...

30.06.2025 12:26 👍 222 🔁 97 💬 10 📌 3
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How a Scientist Followed Curiosity (and Love) to Build an Innovative Tool to Track Changes in the Gut Microbiome Despite how common they are, scientists still don’t fully understand why some people develop allergies while others don’t.

A nice blog post about our work www.nature.com/articles/s41... can be found here mgriblog.org/2025/08/04/c...

05.08.2025 00:36 👍 1 🔁 1 💬 0 📌 0
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Silence on the relevant literature and errors in implementation - Nature Biotechnology Nature Biotechnology - Silence on the relevant literature and errors in implementation

Im working on something and I am reminded of one of the wildest correspondences ever published www.nature.com/articles/nbt...

16.07.2025 01:16 👍 1 🔁 0 💬 0 📌 0
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The paper has the incorrect dynamics for gLV

12.07.2025 17:21 👍 0 🔁 0 💬 0 📌 0

The mbtransfer paper also has data leakage issues. In many of the results they apply DESeq2 Normalization in a pre-processing step (for all samples in a bulk process) and include samples which are later used as forecasting test samples when doing so.

12.07.2025 17:21 👍 1 🔁 0 💬 1 📌 0
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MetaPhlAn 4.2.2 release (initial long-read sequencing support and database update) Announcement We are pleased to share that MetaPhlAn 4.2.2 is now available, which incorporates taxonomic profiling of long-read metagenomes for the first time and includes a new version of the MetaPhl...

The new version of MetaPhlAn v4.2.2 released!

📌taxonomic profiling of long-read metagenomes for the first time
📌new version of the MetaPhlAn db (vJan25_202503) containing >21k new SGBs

Try it out & @hutlab.bsky.social and we are looking forward to your feedback!
forum.biobakery.org/t/metaphlan-...

11.06.2025 06:15 👍 55 🔁 25 💬 2 📌 1

Our paper is now open access as well.

29.05.2025 16:23 👍 4 🔁 1 💬 0 📌 0
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Incorporating scale uncertainty in microbiome and gene expression analysis as an extension of normalization - Genome Biology Statistical normalizations are used in differential analyses to address sample-to-sample variation in sequencing depth. Yet normalizations make strong, implicit assumptions about the scale of biologic...

New paper in Genome Biology!

genomebiology.biomedcentral.com/articles/10....

We introduce scale models, a generalization of normalizations that explciitly account for uncertainty in biological system scale (e.g., microbial load).

22.05.2025 16:43 👍 8 🔁 3 💬 2 📌 0
Call for papers on the clinical microbiome - Nature Microbiology Nature Microbiology has launched a joint collection on the clinical microbiome with Nature Communications, Nature Medicine and Communications Medicine.

This month's editorial is an invitation to submit papers on clinical and translational aspect of the microbiome.

This collection is a joint effort with @naturemedicine.bsky.social @natcomms.nature.com and @commsbio.nature.com

#MicroSky #MicrobiomeSky 🦠⚕️🧪⚕️

www.nature.com/articles/s41...

06.05.2025 19:37 👍 25 🔁 18 💬 3 📌 1
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Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain - Nature Microbiology ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal information associated with e...

🚨 Out now!

Chronostrain - a method to profile low abundance strains in longitudinal microbiome samples 🦠💻

@travis.gibsonlab.io @younhk.bsky.social @gibsonlab.io @harvardmed.bsky.social @broadinstitute.org

#MicroSky 🦠 #MicrobiomeSky

www.nature.com/articles/s41...

06.05.2025 18:54 👍 41 🔁 28 💬 0 📌 2

reviewer 3 or 2?

06.05.2025 22:51 👍 1 🔁 0 💬 0 📌 0
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Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain Nature Microbiology - ChronoStrain accurately profiles low-abundance strains in longitudinal samples by jointly modelling nucleotide sequencing errors, strain presence/absence and the temporal...

"Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain" - Kim et al.

rdcu.be/ekTwf

06.05.2025 16:27 👍 1 🔁 1 💬 0 📌 0
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It is a great pleasure to listen to @seppekuehnlab.bsky.social
His talk is about ´Learning microbiome design principles from natural variation ´.

Below, the #liveSketch painting during the seminar and given at the end!

#ArtAndScience #MediationScientifique

05.05.2025 10:30 👍 5 🔁 3 💬 2 📌 0
Openings Positions available in the Gibson Lab

Several Postdoctoral Fellow openings. All fellows have triple appointment at HMS,BWH, and Broad

- Biological sequence models (theory, design, and application)
- Learning single cell dynamics
- Bacteriotherapy design, “bugs-as-drugs” (using control theory principles)

gibsonlab.io/openings/

17.04.2025 14:02 👍 2 🔁 1 💬 0 📌 0

We are still accepting registrations for this event! Please come join us and hear about cutting edge microbiome research.

17.03.2025 20:05 👍 8 🔁 3 💬 0 📌 0
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Planning and describing a microbiome data analysis - Nature Microbiology We provide guidance on the planning, execution and description of statistical analyses in microbiome studies.

A must-read for any microbiome researcher 🦠📐and a new addition to our #bestpractices series

Planning and describing a microbiome data analysis by @amydwillis.bsky.social and @davidandacat.bsky.social

www.nature.com/articles/s41...

21.02.2025 14:48 👍 58 🔁 26 💬 1 📌 1
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Paper just accepted

Gibson et al. "On the stability of gradient descent with second order dynamics for time-varying cost functions" Transactions Machine Learning Research (2025)

openreview.net/forum?id=Hlz...

07.02.2025 16:35 👍 2 🔁 1 💬 0 📌 0
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SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.

Happy to share our new paper in @naturemicrobiol.bsky.social on mapping spatial relationships of the human gut microbiome. We identified distinct spatial hubs between gut bacteria that reflect sub-community assemblies at the micron-scale. Led by Miles Richardson & co.
www.nature.com/articles/s41...

03.02.2025 14:46 👍 89 🔁 36 💬 0 📌 0
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Ethics of Caring - National Nursing Ethics Conference on LinkedIn: #nursing #ethics #nursingethics #clinicalethics #socialworkers #socialwork… “We can’t underestimate the power of storytelling…stories have a way of speaking to the humanity within each of us and can help remind us of the humanity in…

Join us in LA this March!

31.01.2025 18:19 👍 1 🔁 1 💬 0 📌 0

Are regret based adaptive control strategies deployable?
arxiv.org/abs/2501.04572

09.01.2025 14:38 👍 0 🔁 0 💬 0 📌 0
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How can I run two isolated installations of Homebrew? I want to install and run two versions of Homebrew simultaneously on an Apple Silicon Mac: an ARM64 version, and an Intel version running under Rosetta 2. I know I can prepend any brew command with...

This post has saved hours when trying to get old x86 bioinformatics pipelines working on Mac arm64 (like pplacer)

stackoverflow.com/questions/64...

16.12.2024 15:22 👍 1 🔁 0 💬 0 📌 0

It’s easy to think this is about politics, but Ran’s actually just subtweeting my working style

08.12.2024 18:16 👍 13 🔁 2 💬 1 📌 0

As further evidence you should send them the @abrahamgihawi.bsky.social paper that invalidated and lead to the retraction of the Nature paper about a cancer microbiome.

03.12.2024 13:23 👍 5 🔁 0 💬 0 📌 0