MedChem.fi's Avatar

MedChem.fi

@medchem.fi

University of Turku Biomedicine CADD&Synthesis PPIs, macrocycles, small molecules… @opentika.bsky.social

28
Followers
23
Following
27
Posts
16.11.2024
Joined
Posts Following

Latest posts by MedChem.fi @medchem.fi

Join our team!

05.02.2026 16:18 👍 0 🔁 0 💬 0 📌 0
Preview
Enhancing the Predictive Power of Macrocyclic Drug Permeability by Knowledge Distillation from Analogous Pretraining Data Macrocyclic drugs offer powerful opportunities for modulating protein–protein interactions, yet their development is limited by poor and unpredictable membrane permeability. Experimental testing is sl...

We introduce Multi_DDPP, a deep learning framework that predicts macrocyclic permeability from 2D structure. Knowledge distillation from multi-assay datasets; improves robustness and enables prioritization of macrocycles for challenging targets. pubs.acs.org/doi/10.1021/ac…

22.12.2025 17:34 👍 1 🔁 0 💬 0 📌 1
merry xmas with flash in the night

merry xmas with flash in the night

Today, we're showcasing our old integrin ligand, which fluoresces beautifully when binding. Just like the song "Flash in the Night," our experiments are lighting up the lab with brilliant results. As we celebrate the magic of science and the joy of the season, we wish everyone a Merry Christmas.

24.12.2024 06:36 👍 1 🔁 1 💬 0 📌 0
final countdown

final countdown

Today, we're gearing up for the big day with a flurry of activity in the lab. Just like the excitement of the final countdown, our experiments are reaching their peak. We're wrapping up our projects and preparing for the holiday break, but not without a few last-minute discoveries!

23.12.2024 06:34 👍 1 🔁 1 💬 0 📌 0
hsd1 ligand with Birdy

hsd1 ligand with Birdy

Today, we're channeling the creative spirit of 22-Pistepirkko as we dive into our experiments. Just like the song "Birdy" takes you on a whimsical journey, our research is soaring to new heights.

22.12.2024 06:28 👍 1 🔁 1 💬 0 📌 0
Some molecules from the past

Some molecules from the past

Today, we showcase some amazing molecules! These compounds show great promise in treating thrombosis, and we're thrilled with the results. Just like hitting 21 in blackjack, our virtual screening has funneled down a large number of candidates to a select few winners.

21.12.2024 05:52 👍 1 🔁 1 💬 0 📌 0
20th century reindeer

20th century reindeer

Today, we're channeling some retro vibes in the lab with our exciting experiments! Just like T. Rex's "20th Century Boy," we're bringing a touch of rock 'n' roll to our research. Whether it's synthesizing new compounds or discovering with CADD, our lab is buzzing with energy and holiday cheer.

20.12.2024 05:00 👍 1 🔁 1 💬 0 📌 0
Video thumbnail

Happy!

19.12.2024 10:25 👍 1 🔁 1 💬 0 📌 0
ror gamma t ligands

ror gamma t ligands

Today, we're diving deep into the "Funnel of Love" with our virtual screening experiments! Just like Wanda Jackson's hit, we're spinning around with excitement as we funnel down a large number of molecules to a select few promising candidates.

19.12.2024 04:34 👍 1 🔁 1 💬 0 📌 0
De novo designed a2b1 integrin ligand

De novo designed a2b1 integrin ligand

Today, we're rockin' and rollin' in the lab with some high-energy experiments! Just like the Stray Cats' "18 Miles to Memphis," we're on a journey of discovery, pushing the boundaries of science. Whether it's synthesizing or designing new compounds, our lab is buzzing with excitement.

18.12.2024 04:17 👍 1 🔁 1 💬 0 📌 0
Edge of 17

Edge of 17

Today, we're on the edge of our seats with excitement as we dive into some thrilling experiments! Inspired by Stevie Nicks' "Edge of Seventeen," we're bringing a touch of rock 'n' roll to our research. Whether it's synthesizing new compounds or modeling, our lab is buzzing with energy.

17.12.2024 04:24 👍 1 🔁 1 💬 0 📌 0
Sweet sixteen with one of our patents as inventors

Sweet sixteen with one of our patents as inventors

Today, we're rocking! We're bringing a touch of rebellious spirit and excitement to our research. Whether it's synthesizing new compounds or discovering through modeling, our lab is buzzing with energy.

Why did the scientist install a knocker on his door? Because he wanted to win the No-bell prize!

16.12.2024 04:28 👍 1 🔁 1 💬 0 📌 0
Fluoresing molecule, which looses its power by reaction

Fluoresing molecule, which looses its power by reaction

Today, we're playing with some fascinating fluorescing compounds! Just like Belinda Carlisle's hit "Leave a Light On," we're lighting up the lab with our experiments. But here's the twist—our compounds are so advanced, we can actually shut down the "light" when we need to. Sorry, Belinda!🧪✨

15.12.2024 05:57 👍 1 🔁 1 💬 0 📌 0
fluorescing tool compound

fluorescing tool compound

Today, we're channeling our inner '80s vibe with some high-energy experiments! Just like the iconic movie "Flashdance," we're dancing our way through the lab, makung new compounds.

🔬 Lab Joke of the Day: Why did the scientist break up with the biologist? There was no chemistry! 💔

14.12.2024 05:43 👍 2 🔁 1 💬 0 📌 0
Hsd1 ligand discovery back then.

Hsd1 ligand discovery back then.

Today, we're feeling lucky in the lab with old stuff! A touch of nostalgia and charm to our research. Whether it's whipping up new compounds or uncovering groundbreaking virtual screening, our lab is buzzing with excitement and a sprinkle of holiday magic. Who knew science could be this much fun?

13.12.2024 04:24 👍 2 🔁 1 💬 0 📌 0
old molecule from our lab

old molecule from our lab

🎄🔬 Day 12: The Dirty Dozen! 🔬🎄
Just like the classic movie, we're bringing together a team of daring and innovative ideas to tackle some of the toughest challenges in medchem - follow us for our latest innovations. From synthesizing new compounds to virtual screening 🧪✨

12.12.2024 04:39 👍 2 🔁 1 💬 0 📌 0
11

11

🎄🔬
Today in the lab, we're turning up the heat with some electrifying experiments! Just like the classic hit "Come on Eileen," we're all about hitting the right notes in our research. We're dancing to the rhythm of science. 🧪✨

11.12.2024 04:37 👍 1 🔁 1 💬 0 📌 0
Aromatase inhibitor with 10/80

Aromatase inhibitor with 10/80

✨ It's Day 10, and we're hitting the perfect 10 with a tribute to Hurriganes' "10/80"! 🚀 At MedChem.fi, today’s featured molecule is an all-time favorite from our archives. As we journey through our countdown to Christmas, let’s rock this day with the spirit of 10/80. 🧪✨

10.12.2024 04:31 👍 1 🔁 1 💬 0 📌 0
Forest @ winter, molecule of the day.

Forest @ winter, molecule of the day.

✨ It's Day 9, and we're brewing up something special—"Love Potion Number 9"! 🚀 At MedChem.fi, today’s featured molecule is magical, just like the tune. We’re rocking this countdown with a dash of chemistry and a lot of love for our work. 🧪✨

09.12.2024 04:54 👍 1 🔁 1 💬 0 📌 0
Eight days a week

Eight days a week

✨ It's Day 8, and we've got molecules for days—"Eight Days a Week," to be exact! 🚀 At MedChem.fi, today's molecule is as timeless as the classic tune, and we're rocking it the Hurriganes way.🧪✨

08.12.2024 04:27 👍 1 🔁 1 💬 0 📌 0
molecule 67

molecule 67

✨ Welcome to Day 7! 🚀 Today, we're rocking with a little twist on Bryan Adams' classic—let's call it "Summer of '67". At MedChem.fi, we're featuring molecule 67, a standout from our publications. m members.🧪✨

07.12.2024 04:48 👍 1 🔁 1 💬 0 📌 0
molecule serie for our independence day

molecule serie for our independence day

✨ On this special Day 6, we're celebrating Finland’s Independence Day with a tribute to our national composer, Jean Sibelius, and his masterpiece "Finlandia". 🚀 At MedChem.fi, today's featured molecule shines as brightly as our nation's spirit. 🧪✨

06.12.2024 05:06 👍 1 🔁 1 💬 0 📌 0
coumarins for mao-enzyme

coumarins for mao-enzyme

✨ It’s Day 5, and we’re trekking “Five Hundred Miles” with our next molecule! 🚀 At MedChem.fi, today’s featured molecule has traveled far in our research journey. Just like the song, this molecule has gone the distance, and we're excited to share its story. 🧪✨

05.12.2024 10:14 👍 0 🔁 0 💬 0 📌 0
Molecule 4 put on top of the fingerbread man

Molecule 4 put on top of the fingerbread man

✨ On the fourth day of our countdown, we're singing a different tune! 🚀 Today, join us in celebrating another molecule from our archives at MedChem.fi. As Alphaville would sing, "Fourever Young," this star molecule still shines bright in our memories.🧪✨

04.12.2024 03:50 👍 1 🔁 1 💬 0 📌 0
Macrocycles from the era when they were not called macrocycles.

Macrocycles from the era when they were not called macrocycles.

✨ Step into our molecular time machine! 🚀 Part 3/24 of our trip down memory lane, showcasing a molecule a day from our archives until the 24th of December. Join us at MedChem.fi as we revisit the chemical stars of our publications and patents—each one with a story to tell! 🧪✨

03.12.2024 03:57 👍 1 🔁 1 💬 0 📌 0
MedChem.fi’s Advent calendar part 2. Some iGluR molecules.

MedChem.fi’s Advent calendar part 2. Some iGluR molecules.

Welcome to MedChem.fi’s X-mas Molecule Extravaganza! 🎅💊 Each day, we’ll unwrap a shiny new molecule (or a whole squad of them) straight from our research papers and patents—because nothing says holiday cheer like cutting-edge chemistry! 🧪✨
@uniturku @medchemfiutu

02.12.2024 03:53 👍 1 🔁 1 💬 0 📌 0
Figure with one of our old molecules…

Figure with one of our old molecules…

Welcome to MedChem.fi’s X-mas Molecule Extravaganza! 🎅💊 Each day, we’ll unwrap a shiny new molecule (or a whole squad of them) straight from our old research papers and patents—because nothing says holiday cheer like cutting-edge chemistry! 🧪✨

01.12.2024 05:32 👍 3 🔁 1 💬 0 📌 0