@rnadavid
RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. IDPs, biomolecular condensates and RNA fun @HymanLab. MBL Physiology '25. And birds. ebird.org/profile/MjcyMDU0Nw inaturalist.org/people/9261834
A Common Toad sits motionless in the grass, staring dead ahead with a grumpy, resigned expression. Its squat, unimpressed face perfectly captures the Monday mood...tired, unbothered, and just surviving.
The official face of Monday.
#MondayMotivation
Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...
Male Lesser Spotted Woodpecker, Kent
Female Lesser Spotted Woodpecker, Kent
Had a superb weekend in Kent courtesy of @lesserspotnet.bsky.social’s workshop, hearing of all the exciting developments in Lesser Spotted Woodpecker monitoring & research, topped by great views of the birds themselves 😍 - my first for a decade!
Full paper and research summary now out in Science: www.science.org/doi/10.1126/.... Also, an excellent summary of our work in the Times: www.thetimes.com/uk/science/a...
Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here:
mbg.au.dk/en/news-and-...
Our work on #hornwort #pyrenoids is finally out in @science.org! 🎉 We uncovered how hornworts pack their Rubisco into pyrenoids and successfully recreated them in Arabidopsis. A key step toward engineering more efficient photosynthesis in crops @btiscience.bsky.social www.science.org/doi/10.1126/...
Congratulations Leo!!!!!
All the best to you & Ubiquitin & all the other proteins!:)
I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)
You have less than a week left to submit your abstract for #EESMicrotubules! ⏰ Don't miss out on the main event for researchers who share an interest in microtubule biology and its relevance to human health and disease ➡️ s.embl.org/ees26-09-bl
✒️ Abstract deadline: 11 March
🤩to see this behemoth of a story out !
Pushed by @nikobiota.bsky.social & the Amazing @embl.org AML Team (Tina, Michael, Paulina) and in Co. with the Best #science #family you can dream of!
This truck was #home, for weeks in a row & in my heart for a lifetime.
www.biorxiv.org/content/10.6...
IDPSeminars is back TOMORROW! Come see @tanjamittag.bsky.social and @xsalvatella1.bsky.social ! Not to be missed!!
We are delighted by the publication of our work identifying human LBR and LAP2 as key heterochromatin tethers at the nuclear envelope.
Their loss massively changes 3D chromatin organization, and causes defects in epigenetic maintenance and cell fate determination.
doi.org/10.1038/s415...
Join us in beautiful Portugal for the best & most comprehensive meeting on RNA localization and local translation! > 30 talks will be selected from abstracts. Held for over 30 years, this meeting is small enough to meet leaders in the field, yet big enough to cover a breadth of cutting-edge science.
🚨New paper: We found - contrary to expectations - that oxygen is partially excluded from biomolecular condensates.
We find a strong anti-correlation between oxygen and protein concentrations in the condensate showing that accessible volume dominates over polarity.
www.nature.com/articles/s41...
How do biomolecular condensates🫧 interact with membranes? We show that dielectric permittivity contrast between coexisting phases directly governs condensate wetting behavior.
👉 preprint: bit.ly/4qBmVRx
Permittivity matters.🧪🫧
RNA-specific local translation is patterned by condensates for multinucleate cell growth
www.nature.com/articles/s41...
Do you work on DNA or RNA protein complexes? 🧬
Come to Machines on Genes this June in Crete! ☀️
Super early discount is ending this Sunday so register now! 😃
A Long-tailed Tit dangles awkwardly from one foot on a thin branch, its tiny body swinging below, clinging on for dear life, just like the rest of us on a Monday.
Still clinging to the weekend. No current plans to let go.
#MondayMotivation
Are you interested in working with a fresh team on cutting edge protein design?
We're hiring a Technical Assistant for our protein design team at DKFZ Heidelberg: jobs.dkfz.de/en/jobs/1683...
Please share!
Happy to share our first preprints from work originating at Cornell!
Takumi's paper describes how small molecules shift phase equilibria of condensates by focusing on the dilute-phase response. It shows how metabolites may tune stability and material properties.
www.biorxiv.org/content/10.6...
Our second Cornell-era preprint is also out!
Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses.
Congrats, Kaarthik and the team!
www.biorxiv.org/content/10.6...
Unfathomable what is dwelling in the deep...
🦜 The genomes of fours species in this study were sequenced and assembled at @mpi-cbg.de. The Cell Technology Facility extracted the relevant RNAs for the functional analyses. 🦜
Growing up with Pokémon has inspired me to engage in curiosity driven exploration & research and is apart from Charles Darwin the main motivation for me to dabble in naturalist activities, such as birding!🐦🦆🦉
Happy 30th birthday, Pokémon! Since 1996, the Japanese media sensation has inspired generations of researchers in fields as diverse as evolution, biodiversity and research integrity. go.nature.com/4bcjZ9w
Excited to share our new preprint showing cGAS mediates innate immune activity in TDP-43 proteinopathy. Pharmacological inhibition of cGAS restores microglial function, corrects RNA mis-splicing, & protects motor neurons across human iPSC & mouse models of ALS www.biorxiv.org/content/10.6...
MicroSEA (Microbial Sea Eukaryotes) course is a one-week, field-based summer school to train early-career researchers in the diversity, ecology, and single-cell biology of marine protists. MicroSEA course integrates lectures, field sampling, and lab-based practicals in advanced techniques, such as flow cytometry, microscopy, culturing, and molecular analysis. The main objectives of MicroSEA course are: Fostering a deep understanding of marine protist diversity, ecology and biology; Providing hands-on training in advanced single-cell methods that are not commonly available in university programs; Building participants' confidence in designing and conducting research projects from field to data analysis; Promoting international collaborations and peer networking among students and speakers/trainers. The course will take place at the Station Biologique de Roscoff - SBR (France) - 7th to 12th of June, 2026 (arrival on the 6th, departure on the 13th). 20 participants will be selected, including 10 from EuroMarine member institutes. https://opbc.sciencesconf.org/
Protist lovers: Please apply for a week of rhapsody! Learn by doing:
MicroSEA (Microbial Sea Eukaryotes) course is a one-week, field-based summer school to train early-career researchers in the diversity, ecology, and single-cell biology of marine protists. opbc.sciencesconf.org
#protistsonsky
I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Our recent work showing that tau phosphorylation alters cooperative binding and organelle transport in neurons is now posted at @elife.bsky.social. A big thanks to the reviewers and editors for their thoughtful assessment.
doi.org/10.7554/eLif...
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.