Sebastian Urbano

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuropathy.

Nature research paper: Mitochondrial transfer from glia to neurons protects against peripheral neuropathy

go.nature.com/4juoEq1

Self-renewal of neuronal mitochondria through asymmetric division - preLights Neurons contain “hotspots” for mitochondrial biogenesis at distal branch points

Check out my first @prelights.bsky.social article, based on some great work done by Dr. Tejashree Waingankar & @samlewis.bsky.social at UC Berkeley 🔬🧬🧠

prelights.biologists.com/highlights/s...

MISO regulates mitochondrial dynamics and mtDNA homeostasis by establishing membrane subdomains - Nature Cell Biology Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostat...

☕Zhang et al. characterize the #mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner #mitochondria membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation.
👉https://rdcu.be/eXjMB
bit.ly/3YZ0PNj

Multiscale structure of chromatin condensates explains phase separation and material properties The structure and interaction networks of molecules within biomolecular condensates are poorly understood. Using cryo–electron tomography and molecular dynamics simulations, we elucidated the structur...

@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.

@attychang.bsky.social, @nanigrotjahn.bsky.social et al. show that cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/...

📕 From The Year In Cell Biology: rupress.org/jcb/collecti...
#CellBio2025

Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
www.cell.com/molecular-ce...

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase

www.science.org/doi/10.1126/...

DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation Wang et al. reveal a role of DNMT1, traditionally known for DNA methylation, in regulating mitochondrial health through RNA modification. Their findings explain how the mutation in DNMT1 disrupts cellular energy metabolism, contributing to neurological disorders, and suggest therapeutic potential targeting RNA methylation in neurodegenerative diseases.

Online Now: DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation Online now:

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Dynamic DnaA-DnaB interactions at oriC coordinate the loading and coupled translocation of two DnaB helicases for bidirectional replication https://www.biorxiv.org/content/10.1101/2025.06.05.657979v1

Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature Communications The actin cytoskeleton is crucial for cell and organelle motility. Here, the authors show that actin acts upstream of the mitochondrial fusion machinery to bridge two fusing mitochondria.

Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature Communications

congrats @manorlaboratory.bsky.social & CO

www.nature.com/articles/s41...

Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan - Communications Biology Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...

Cool new work from the lab by @chris-morrow.bsky.social: Often we think of auto-fluorescence as a hindrance to experiments - but endogenous metabolites have specific fluorescence we can use to determine the metabolic state of the cell - and predict lifespan.. www.nature.com/articles/s42...

Cryo-EM map and atomic model of the RAVE complex (regulator of ATPases of endosomes and vacuoles) bound to a partial V1-ATPase complex

Atomic model showing that the RAVE complex binds to a region of the V1 complex subunit A not found in the homologous ATP synthase subunit beta.

Most protein complexes are born only once. V-ATPase assembles over and over as part of its regulatory mechanism, enabled by RAVE (regulator of ATPase of vacuoles and endosomes)
@hanlinw222.bsky.social's 1st struct of RAVE bound to a partial V1 complex now out in PNAS.
www.pnas.org/doi/10.1073/...

Hi! I would like to be added to the starter pack. Thank you!

Hi! I would like to be added to the starter pack. Thank you!

Hi! I would like to be added to the starter pack. Thank you!

Hi! I would like to be added to the starter pack. Thank you!

Hi! I’m a PhD student at the Hernandez Lab @ Tufts. I’m into polymerases, helicases, non-B DNA structures, and metabolism—all the cool science! I also love computational modeling and understanding the molecular details that power life.