Lead-DBS

Please support Lead-DBS by buying our Lego Kit. Its also fun!

For a discussion of why our conclusions may differ from those of van den Heuvel et al., please see our preprint:
www.biorxiv.org/content/10.6...

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method.
See below 👇 for our response.

www.biorxiv.org/content/10.6...

BME at the University of Utah has an opening for a tenure-track faculty position focused on biomedical imaging! I'd love to see some strong applications in neuroimaging come through 😎 Also happy to chat about my experience as new faculty here!
utah.peopleadmin.com/postings/196...

The deep brain stimulation response network in Parkinson’s disease operates in the high beta band Bahners et al. identify a brain network linked to optimal therapeutic outcomes in patients with Parkinson’s disease receiving deep brain stimulation. This

New @netstim.org publication alert: @bahnebahners.bsky.social in BRAIN out now:

academic.oup.com/brain/advanc...

A 🧵:

"You see what you look for, and you look for what you know."

We are proud to release FOCUS: a 100 μm deformable human subcortical atlas precisely registered to MNI space.

www.biorxiv.org/content/10.6...

🧠 Deep brain stimulation for Parkinson’s disease achieves its best results when a precisely defined brain network operating in the high beta frequency range is targeted. This was shown by a team @andreashorn.org @bahnebahners.bsky.social in both space and time for the first time.👇
uni.koeln/5LYV7

🧠 Die Tiefe Hirnstimulation bei Parkinson zeigt ihre bestmögliche Wirkung, wenn ein präzises Gehirnnetzwerk im Beta-Frequenzbereich (20–35 Hz) stimuliert wird – das zeigt ein Team um @andreashorn.org @bahnebahners.bsky.social jetzt erstmals gleichzeitig räumlich und zeitlich👇
youtu.be/ZrREFuDI-as

It was a great joy to talk to Ludvic Zrinzo about DBS, lesioning and how it all may work: stimulatingbrains.org/74-ludwig-zr...

Thanks to Niels Pacheco for producing the episode!

What is the status of DBS for epilepsy?
Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/

A 🧵 — please RT for reach! 🙏

See you in Geneva! We have such an incredible line up of speakers this year!
#optoDBS2026 – registration now open at www.optodbs.ch

As last time, we are expanding scope way beyond just DBS and optogenetics – for instance including TMS and LIFU applications this year!

From Adaptive DBS to Adaptive Circuit Targeting 👇👇

Next steps ahead for DBS! 👇👇

Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇

New Institute paper out 👇👇

Unfortunately, there is no simple answer and as always, the method depends on the research question. However, these four methods have now all been included into Lead-DBS/OSS-DBS and can be conveniently analyzed on group level using the FiberFiltering Explorer (www.lead-dbs.org).

Should we use
• Electric Field Magnitude
• Electric Field projections onto fibers
• Pathway Activation Modeling
• probabilistic Pathway Activation Modeling?

How should we best model recruitment of axons by deep brain stimulation?
Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications:

academic.oup.com/braincomms/a...

Super excited for Ningfei Li to receive the highly prestigious NSFC Excellent Young Scientists Fund – as of yesterday, Ningfei is Full Professor at the Xian University and has joined a new AI institute! We are both excited to continue our collaboration on @lead-dbs.org and connectomic DBS!

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇

stimulatingbrains.org/72-john-rols...

How may traveling waves in the brain impact seizure focus detection in functional neurosurgery?
How does RNS for epilepsy really work?
Are we ready for stem cell therapy in PD?
DBS for disorders of consciousness?

Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

🧠 ⚡️ Preprint alert ⚡️ 🧠

I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why.

Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes
www.researchgate.net/publication/...

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested!

lnkd.in/eEbnXByJ

@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI!

@braincircuits.bsky.social

Hard to keep track about all the great things our labmembers have achieved recently:

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively.

Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET

Register here: partners.zoom.us/webinar/regi...

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?