Hidalgo Lab | Mapping Innate Immunity Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com

Thank you to Gerardo Barcia for his beautiful design and constant support in building it

Also our thanks to #Gerry_Nicholaes #Hector_Bueno and many others who were important collaborators
Support always from #CNIC #Yale_VBT @yaleschoolofmed.bsky.social
And very special to @caixaresearch.bsky.social for funding this work

Kudos to @Aleejandra__ and the amazing #Sandra_Martin that performed tons of MI work including a full circadian experiment!
This would have not been possible with the generous support of @casanova-acebes.bsky.social and @mariangelesmoro.bsky.social

A circadian checkpoint relocates neutrophils to minimize injury | Journal of Experimental Medicine | Rockefeller University Press Aroca-Crevillén et al. identify a circadian checkpoint in neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their int

Find out more here
rupress.org/jem/article/...

We then use a skin model to visualize the mechanism of this protection. The excitement came from finding that blocking the circadian clock repositions neutrophils right into the injury zone - thereby sparing the healthy tissue from the cytotoxicity of neutrophils

With #Lidiane_Torres we show this also protects the vasculature in sickle cell disease by blunting aggressive behaviors

We uncover a circadian “checkpoint” in neutrophils that naturally reduces inflammation by targeting their intrinsic circadian clock!
Activating CXCR4 represses circadian-related activation of neutrophils, critically reducing inflammatory injury to the infarcted heart

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

@yaleschoolofmed.bsky.social and importantly also #CNIC_Cardio

📰 Press Release: Researchers at @yaleschoolofmed.bsky.social have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils. www.eurekalert.org/news-release...

See original paper from the @drusqui.bsky.social group: rupress.org/jem/article/...

Our gratitude to those who helped us polish our ideas into a more decent text
@snarasimhan.bsky.social and the anonymous reviewers at @cp-cell.bsky.social
@casanova-acebes.bsky.social #Daniela_Quail @dcerezowallis.bsky.social #Laiguan_Ng

Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...

For a better understanding of where these ideas came from, check out our recent paper modeling the entire neutrophil compartment with @dcerezowallis.bsky.social #AndreaRubio and #Laiguan_Ng
www.nature.com/articles/s41...

Spoiler: We model the power of neutrophils as a reflection of their Collective behavior. Yes, just like insects… they become powerful. Here’s an idea of how this works

What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan?
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇

authors.elsevier.com/a/1mFj9L7PXu...

Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Nature research paper: Architecture of the neutrophil compartment

go.nature.com/4oD2Nh5

Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter, Greter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...

Kudos to the wonderful people in our labs who made this possible
@dcerezowallis.bsky.social #andrea_rubio #ivanbamartin #LaiguanNg

and to the many collaborators who helped us along the way and many many others.
Science is a team sport.

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

Thrilled to share our Perspective on structural immunity, where we discuss how immune cells double as architects, weaving and reshaping the fabric of our tissues. Grateful to @drusqui.bsky.social, all co-authors, and the wonderful @natrevimmunol.nature.com team for making it such a joy to write!

Here is a full-text access to a view-only version of the paper:
rdcu.be/eM7xA

Kudos to @alazozcan.bsky.social, Tommaso, Yuval and Veronique for their insights and work for this review.

Immune cells are more than aggressors; they are also diplomats that prevent conflict by improving the barrier capacity, the ECM, and the mechanical properties of tissues. We are just beginning to scratch the true impact of immune cells on tissues and overall organismal physiology.

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Heart of the matter: Neutrophils, cancer, and cardiovascular disease | Journal of Experimental Medicine | Rockefeller University Press Cancer and cardiovascular disease are the leading causes of death worldwide. Cancer patients display an abnormally elevated burden of cardiovascular diseas

Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social

rupress.org/jem/article/...

The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbrea…

🚨 Our new study is live in The Lancet Microbe!

“The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel
www.sciencedirect.com/science/arti...

A thread 🧵!

Congratulations for this beautiful study, team! 🔥

OBS #Immunology Seminar
Neutrophils and regulation of skin physiology
📆 Thu, 10th April, 12 pm EDT/5 pm CET
🎙️ Speaker
@alazozcan.bsky.social @yalesph.bsky.social
@drusqui.bsky.social @cnic @nature.com

📣 Moderator
@eugecc.bsky.social

us02web.zoom.us/meeting/regi...

Matrix-producing neutrophils populate and shield the skin - Nature A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

Nature research paper: Matrix-producing neutrophils populate and shield the skin

https://go.nature.com/4iJSgy5

Gracias Alejo! 🙏